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D T Janerich

Publications and source records attributed to D T Janerich.

At least 55 records · Page 3Linked to original sources
PubMed1983

Breast cancer and oral contraceptive use: a case-control study.

The effect of oral contraceptive (OC) use was examined among parous breast cancer cases diagnosed at less than or equal to 45 years of age, and in two different general population control groups of parous women. The primary analysis compared 278 cases with 520 controls. In the secondary analysis, a subgroup of 190 cases were compared with 190 controls from another reference group. In both analyses, ever use of OC, duration of OC use, and OC use prior to first pregnancy showed no significant association with breast cancer risk. Also in both analyses, in women with prior benign breast disease OC use increased the risk of breast cancer, although this finding was statistically significant only in the larger group used in the primary analysis.

Adult↗
PubMed1983

Characteristics of first pregnancy in relation to early breast cancer. A case-control study.

We examined some characteristics of first pregnancy in 314 female breast cancer patients whose disease was diagnosed at < 45 years of age and who were identified through a population-based cancer registry in New York State and in 314 control women identified through birth records. Preeclampsia was reported less frequently on the birth records of the first recorded pregnancy in the cases than in those of the controls, with a relative risk of 0.28 (0.05 < p < 0.10, from logistic model). We examined this finding on preeclampsia with particular reference to immunologic mechanisms, but further studies are needed on larger samples. Twinning and maternal Rh factor, also relevant to immunologic factors, were not significantly associated with a higher risk of breast cancer. Among the women whose first pregnancy resulted in a live birth, length of gestation (which is correlated with maternal estriol levels) did not differ between the cases and controls.

Adult↗
PubMed1983

Uses of available record systems in epidemiologic studies of reproductive toxicology.

The uses of available record systems in epidemiologic studies of reproductive toxicology are described with reference to New York State. The available record systems (and relevant reproductive end points) described include: a newborn screening program for metabolic diseases and hemoglobinopathies (relevant to point mutations); chromosome registries and prenatal cytogenetics (for chromosome anomalies); live birth certificates (for birth defects, birthweight, sex ratio, etc); fetal death certificates (for spontaneous fetal deaths); and a statewide cancer registry (for childhood cancers and transplacental carcinogenesis). The uses and limitations of these record systems are discussed, along with examples of their use in descriptive and analytic epidemiologic studies. Descriptive studies outlined include investigations of temporal and geographic trends in birth defects, birth weight, and fetal deaths, with reference to environmental questions (eg, Love Canal, nuclear power plants). Analytic studies described concern parental occupation in relation to specific birth defects (neural tube defects and Down syndrome) and maternal use of contraceptive drugs.

Abortion, Spontaneous↗
PubMed1982

Birth weight and birth defects in relation to maternal spermicide use.

The possible effects of maternal spermicide use on birth characteristics of offspring were examined in two studies. First, birth weight of offspring was examined in a cohort study of 302 women who reported using spermicides and 716 women who used no contraceptive methods in the year prior to pregnancy resulting in a 1974 live birth (without a malformation) in Upstate New York. There was no evidence that spermicide use prior to the last menstrual period (LMP) had an effect on mean birth weight or on the proportion of lower weights. Mean birth weight of female births was significantly lower in post-LMP spermicide users than in pre-LMP-only spermicide users and no-contraceptive users. In multiple linear regression analyses of birth weight among births to spermicide users, including maternal smoking during pregnancy and other variables, time of discontinuation of spermicide use was an important predictor of female (but not male) birth weight. In the second (case-control) study of 715 Upstate New York births with selected birth defects and 715 control births (matched on maternal age and race), no significantly increased relative risks were associated with maternal spermicide use prior to LMP or after LMP. Based on small numbers, relative risks for post-LMP spermicide use were greater than 1.00 for hypospadias (8/2 or 4.00, not significant) and for limb reduction defects (6/3 or 2.00, not significant).

Abnormalities, Drug-Induced↗
PubMed1981

Cancer incidence in the Love Canal area.

Data from the New York Cancer Registry show no evidence for higher cancer rates associated with residence near the Love Canal toxic waste burial site in comparison with the entire state outside of New York City. Rates of liver cancer, lymphoma, and leukemia, which were selected for special attention, were not consistently elevated. Among the other cancers studied, a higher rate was noted only for respiratory cancer, but it was not consistent across age groups and appeared to be related to a high rate for the entire city of Niagara Falls. There was no evidence that the lung cancer rate was associated with the toxic wastes buried at the dump site.

Carcinogens↗
PubMed1980

The influence of pregnancy on breast cancer risk: is it endocrinological or immunological?

Epidemiological data are presented to show that pregnancy is related to a short-term increase in breast cancer risk which precedes its well recognized lower rate for the remainder of life. The data confirm and extend related findings from several earlier studies, and suggest that the biological mechanism which produces the apparent protective effect resulting from pregnancy also produces a short-term adverse effect which is approximately proportionate to the protective effect. This phenomena seems important in terms of what it reveals about the natural history of breast cancer. It is proposed that the general biological mechanism underlying this effect is the immune tolerance during pregnancy which allows the female's immune system to tolerate a fetus whose genes and antigens are partially dissimilar to her own. It is further suggested that the specific mechanism responsible for the phenomena is either a mammary tumor virus or the woman's immune reaction to unidentified fetal antigens that are common to human fetal cells and mammary cancer cells.

Adult↗
PubMed1980

The incidence and causes of death in a follow-up study of individuals with haemoglobin AS and AA.

A cohort of 574 black Adults (mean age 47 years with a range of 28-73 years) with sickle cell trait (haemoglobin AS) which had been age and sex matched with 1148 controls (haemoglobin AA) was monitored for 7 years. We found no evidence of excess mortality or differential causes of mortality between cases and controls. There were no case deaths related to kidney disease, splenic infarcts, or pregnancy. Reports in the literature have been inconsistent with regard to the health effects of sickle cell trait. These findings suggest that discrimination against trait carriers in terms of life insurance premiums and some job opportunities are unjustified.

Adolescent↗
PubMed1980

Sex of first child as a prognostic factor for breast cancer in young women.

In a study in upstate New York, incidence and survival rates of 317 young women (less than 45 years), diagnosed with breast cancer, were examined in relation to the sex of each woman's first offspring. While incidence of breast cancer was not found to be affected by the sex of the first child, prognosis was poorer when the first child was made (p less than 0.05). The authors examined the effect of stage at diagnosis, interval between first pregnancy and diagnosis and concurrent pregnancy at the time of diagnosis as factors other than sex of first offspring that might have an additional influence on survival. Among these, only interval had an effect, and it was of weak statistical significance (0.05 less than p less than 0.1). These findings regarding survival in relation to the sex of the offspring are opposite to those reported recently in France by Juret et al. (Lancet 1:415-416, 1978). Possible differences between the two studies which may account for the opposite findings are discussed.

Breast Neoplasms↗
PubMed1980

Oral contraceptives and birth defects.

This report compares the history of oral contraceptive (OC) use for 715 New York state women who gave birth to malformed infants with the history for a group of 715 matched controls who gave birth to normal children. The case mothers were found to have used the OC after last menstrual period (LMP), or just before conception, slightly more often than the controls. Confidence intervals for the relative risk estimates were wide, and were significantly higher than 1.0 only among the group of women whose children had one or more major structural or anatomical malformations. Cytogenetic abnormalities and hypospadias were not associated with OC use around or after the time of conception. For women who had children with major anatomical or structural malformations, the association with OCs was stronger among the older age group. The authors found no evidence of an increased risk among women who had conveived their child after one or more pill-free menstrual cycles. Several reported studies, including this one, show a predominance of males among malformed offspring whose mothers used OCs during pregnancy. These findings indicate that the association between birth defects and OC use around the time of conception is not large, but the association is not easily reconciled with a non-causal explanation.

Abnormalities, Drug-Induced↗
PubMed1980

The epidemiology of sudden infant death in upstate New York: II: birth characteristics.

This study describes the epidemiology of sudden infant death syndrome (SIDS) among infants born during 1974 to upstate New York residents. Birth certificate characteristics for 184 SIDS cases are compared with those of 417 infants dying from other causes in the same age range, 7-365 days. The results confirm the following as infant risk factors: fall or winter birth, low birthweight for gestational age, twin birth, and live birth order three or more. Maternal risk factors include: age under 20, abnormal uterine bleeding during pregnancy, late initiation of prenatal care, less than 12 years of education and single marital status. The increased risk for mothers who first gave birth in their teens and for second-born twins has not been previously reported. The evidence that SIDS babies are small for gestational age, that twins, especially the second born, and babies whose mothers experienced abnormal uterine bleeding during pregnancy are all at increased risk of SIDS suggests that perinatal stress leading to hypoxia is one of the components that determine the risk of SIDS.

Birth Certificates↗