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D T Khokhlov

Publications and source records attributed to D T Khokhlov.

At least 19 recordsLinked to original sources
PubMed1990

[Current concepts of the role of the thymol test in the laboratory diagnosis of viral hepatitis A].

Current notions on the role of the thymol test (TT) in the diagnosis of viral hepatitis A are discussed. Changes in TT results over the course of the disease are presented, starting from the incubation period up to the second-third week; these values are compared to those of hepatitis A specific markers. The earliest TT shifts in hepatitis A are detectable already 15-18 days before the first clinical manifestations, when this parameter surpasses the upper threshold of the range of normal values. The incubation period TT values are 6.9-8.4 U S-H, those during the 3 weeks of the acute period are 9.1-9.7 U S-H. This test earlier reacts to liver inflammation than alanine aminotransferase (a hepatic enzyme) measurement, which fact recommends TT for active early detection of hepatitis A patients in epidemic foci in collective bodies. One more TT advantage over the detection of hepatitis A specific markers in epidemic foci is that it permits the diagnosis of hepatitis whatever its etiology.

Alanine Transaminase↗
PubMed1988

[Epidemiologic evaluation of the immunologic structure of groups with respect to hepatitis A virus].

The members of a newly formed group of persons have been found to be dissimilar in the intensity of their immunity to hepatitis A virus (HAV), the character of changes in the specific antibody level and the time of its retention. In groups with the favorable situation with respect to hepatitis A, the epidemic process takes a latent course. The continuous circulation of the infective agent is ensured by the presence of the asymptomatic and inapparent forms of this infection. Changes in the specific immunostructure of groups with sporadic changes of hepatitis A are directed mainly towards an increase in the proportion of highly immune persons (with the titer of antibodies to HAV exceeding 1:2,000), the number of persons with low and medium antibody levels remaining approximately the same. Under the conditions of the northwestern region, the titer of antibodies to HAV exceeding 1:2,000 in the blood serum ensures the protection of humans from hepatitis A.

Antibody Formation↗
PubMed1985

[Characteristics of the meningococcal carrier state in organized collectives and its role in the development of generalized forms of meningococcal infection].

Complex (epidemiological and bacteriological) investigations of the level and structure of meningococcal carriership among the members of organized collective bodies differing in the epidemiological situation with respect to meningococcal infection have been carried out. The absence of differences between the total level of meningococcal carriership and the morbidity rate with respect to the generalized forms of meningococcal infection has been shown. The presence of cases of meningococcal meningitis in the groups under study has been found to depend on the intensity of the circulation of certain meningococcal serogroups. The possibility of the ecological reservation of the causative agents of meningococcal infection as polyagglutinable forms has been suggested.

Carrier State↗