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D T Krieger

Publications and source records attributed to D T Krieger.

160 records · Page 9Linked to original sources
PubMed1967

Circadian pattern of plasma 17-hydroxycorticosteroid: alteration by anticholinergic agents.

Atropine, administered to cats just prior to the time of the expected circadian rise in levels of 17-hydroxycorticosteroid in plasma, blocks this rise. Atropine does not alter this circadian pattern when administered at other times in the circadian cycle. Results similar to those obtained with atropine have been observed with short-acting barbiturates. Dibenzyline administered just prior to the time of the expected circadian rise is ineffective in blocking this rise. These findings support the hypothesis that the circadian pattern of plasma 17-hydroxycorticosteroid levels reflects activation, by the central nervous system, of the hypothalamicpituitary-adrenal axis during a "critical time period" in the circadian cycle.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

Circadian variation of beta-endorphin-like immunoreactivity in neurointermediate pituitary.

Immunoreactive beta-endorphin-like activity (-IR) and ACTH-IR were determined in rat pituitary lobes and plasma at 4-hr intervals over a 24-hr period. In addition, we measured beta-endorphin-IR in discrete hypothalamic nuclei, and plasma corticosterone levels at the same time points. Significant and replicable circadian variation was detected only in concentrations of beta-endorphin-IR in neurointermediate pituitary and in plasma corticosterone concentrations.

Adrenocorticotropic Hormone↗