Biomedical subjects

D T Rice

Publications and source records attributed to D T Rice.

11 recordsLinked to original sources

PubMed1991

Immunoglobulin D benign monoclonal gammopathy. A case report.

The authors report a case, perhaps the first, of immunoglobulin D (IgD) benign monoclonal gammopathy. The patient, a 48-year-old black woman, initially had a 500 mg/dl IgD-lambda M-spike, hypercalcemia, and anemia. There was no bone pain, lytic bone lesions, or evidence of renal failure. The bone marrow showed 2.8% plasma cells with a diffuse (not nodular) IgD plasmacytosis and strong lambda predominance. Only trace amounts of free lambda light chains could be demonstrated by immunoelectrophoresis in serum and concentrated urine. The anemia responded quickly to iron therapy. Chemotherapy was not initiated. Over the 6+ years of follow-up, the patient has had no progression of clinical disease attributable to her IgD monoclonal gammopathy. The IgD M-spike has steadily decreased.

Blood Protein Electrophoresis↗

PubMed1988

Intervertebral disk material: criteria for determining probable prolapse.

To develop histologic criteria that allow distinction of prolapsed from nonprolapsed intervertebral disk material, we reviewed the histologic features of curetted fibrocartilage from 100 consecutive patients having documented disk prolapse into the spinal canal and contrasted our findings to those in 40 intervertebral disks removed at autopsy from 20 patients without prolapse. Neovascularization, occurring at the edges of fibrocartilage fragments, was present in 50% of prolapsed disk specimens and in none of the control autopsy disks (p = 0.0004). Other histologic features sometimes used as evidence of degeneration and/or prolapse (i.e., fibrillation, chondrocyte "cloning," and granular change) were not helpful in distinguishing prolapsed from nonprolapsed control disks. Although this indicator was only 50% sensitive in our series, we propose that edge neovascularization of the fibrocartilage fragments is the only reliable histologic clue that intervertebral disk prolapse has occurred.

Adult↗

PubMed1982

Antibody-dependent cellular cytotoxicity with platelets as the target cell: potential application to the study of immune thrombocytopenia.

Antibody-dependent cellular cytotoxicity (ADCC) with platelets as the target cell is demonstrated with white blood cells, platelets and anti-platelet antibody obtained from marmosets. Greatest ADCC activity was observed with cell populations enriched for polymorphonuclear (PMN) cells and adherent cells. Non-adherent cells and lymphocytes obtained from blood pretreated with carbonyl iron showed a lower yet significant degree of activity. The virtual absence of PMNs and monocytes from these preparations indicates that a non-phagocytic-mediated destruction of platelets can occur by an ADCC process. Platelets having IgG deposited on them as a consequence of an autoimmune reaction following an interspecies platelet immunization are not necessarily susceptible to lysis by an ADCC mechanism. The ADCC reaction system as described and the results obtained suggest one can monitor platelets, effectors and soluble factors from immune thrombocytopenic patients and animals with respect to this mode of destruction in vivo.

Animals↗

PubMed1979

Selective mass treatment in a venereal disease control program.

To control syphilis among prostitutes and seasonal farm workers in Fresno County, California, we developed a program of selective mass treatment of prostitutes. From August 1976 to July 1977, 512 women entered the program. Overall, 4.6 per cent of women treated prophylactically for syphilis were actually infected. Compared to cases in the previous year, infectious syphilis cases among prostitutes and seasonal farm workers decreased 51.3 per cent and 26.8 per cent, respectively.

Adult↗

PubMed1970