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Biomedical subjects

D Tănase

Publications and source records attributed to D Tănase.

11 recordsLinked to original sources

[A case of the prune belly syndrome].

Rare heterogeneous syndrome, the prune belly syndrome was first described in 1839 and associates the agenesis of the abdominal musculature with other complex malformations of the genitourinary tract and bilateral cryptorchidism. In this plurimalformative context, the main evolutive problem is represented by the chronic renal insufficiency. The work presents a new case of prune belly syndrome which through its clinical evolutive aspects joins the category of classical cases published in literature.

Humans↗

[Congenital lobar emphysema].

The paper reports on three cases of congenital lobular emphysema with warning respiratory manifestations as early as infancy. Starting from the clinical picture of respiratory distress, the diagnosis was established radiologically. The authors discuss the etiopathogenic aspects of the disease and its clinical-radiological manifestations, with the decisive role of the radiological exploration in diagnosis. The extension of respiratory dysfunction and the possible complications determine the opportunity of surgery.

Combined Modality Therapy↗

[Pneumomediastinum in newborn infants].

The paper reports on two cases of pneumomediastinum in the newborn child: a benign form with clinical picture and radiological scan of subcutaneous cervical emphysema; and a severe form of pneumocystosis complicated with suffocating pneumomediastinum and pneumothorax. The authors discuss the etiopathogenic aspects of pneumomediastinum in the newborn, the clinical and radiological semeiologies, the latter being of a high diagnosis importance. The therapeutic modalities are indicated in terms of the extent to which breathing is affected.

Humans↗

[Mediastinitis in children].

The paper reports on the etiopathogenetic aspects of mediastinitis, clinical and radiological semeiology, the latter with a decisive role in establishing the diagnosis. The priority character of therapy is emphasized. Three cases of mediastinitis in children are presented: a mediastinal abscess, a suppurated mediastinitis with favourable evolution after drainage and a mediastinitis secondary to a fistula on a postcaustic stenosed esophagus.

Abscess↗

Prevention of leukocyte migration inhibitory factor activity by glucagon.

Leukocyte migration inhibitory factor (LMIF) activity was tested before and after glucagon administration both in vivo and in vitro. In vivo glucagon 1 mg i.v. vs saline administration inhibited LMIF production by T lymphocytes in 85.21% patients (p less than 0.01). In vitro glucagon in physiologic (125 pg/ml) and pharmacologic (50 ng/ml) doses increased the migration area vs PPD 250 microL (migration index 0.5127 vs 0.3210; p less than 0.05). These results show a significant inhibitory effect of glucagon upon LMIF activity. We suggest that glucagon acts by enhancement of the intralymphocytic cAMP/cGMP ratio (cyclic adenosine monophosphate/cyclic guanosine monophosphate).

Adult↗