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Biomedical subjects

D Tăpălagă

Publications and source records attributed to D Tăpălagă.

At least 19 recordsLinked to original sources
PubMed1979

[The mechanism of action of phenobarbital on the metabolism of 131J-B.S.P. in cholestasis induced by ANIT in isolated and perfused rat liver (author's transl)].

In order to establish whether the increased B.S.P. secretion in the bile following phenobarbital administration is the consequence of change in the bile output or represents a consequence of the enzymatic induction, the dynamics of the elimination of 131J-B.S.P. was studied in animals treated with ANIT and Phenobarbital in the conditions of isolated perfused liver. At the same time the levels of the conjugation enzyme of B.S.P. were also determined. It was noted that after Phenobarbital the biliary elimination of 131J-B.S.P. is in correlation with the important increase of the output; in the animals treated with ANIT, on the other hand, the biliary excretion of B.S.P. is minimal. The biliary elimination is directly proportional to the increased of the bile output and reflects the changes found in the perfusate. Our findings allow us to assume that the increased of the bile output and in a smaller extent the result of the stimulation B.S.P. conjugation with Gluthation.

1-Naphthylisothiocyanate↗
PubMedDate not supplied

Colchicine treatment effects on liver cirrhosis assessed by liver blood flow measurements.

Hepatic fibrosis is common in all chronic liver diseases. This fibrosis induces morphological, functional and hemodynamic changes. Among the antifibrotic drugs, colchicine gave the most encouraging results. In a group of 22 patients with liver cirrhosis, the hemodynamic changes were studied before and after 24 months of antifibrotic treatment with colchicine (1 mg daily, 5 days a week). The liver blood flow (LBF) was estimated every year by a noninvasive radioisotopic method. After colchicine therapy the determinations showed, an obvious improvement of the liver blood flow with an increase of K (from 0.159 to 0.1678) (p less than 0.001) and a per cent decrease of delta from 44 to 32 (p less than 0.001), thus showing an improvement of the liver blood supply. The simultaneous and favourable changes of the liver biochemical tests and of the sinusoidal hemodynamic parameters strongly suggest that the perfusion improvement, induced by a loss of liver collagen, might explain the tendency of the biochemical data to resume normal values.

Adult↗
PubMedDate not supplied

Circulating immune complexes in chronic hepatitis as related to the presence of HBsAg.

The relationship between the presence of circulating immune complexes (CIC) and of HBsAg in the serum of patients with chronic liver diseases was studied in a group of 78 patients of whom: 16 with chronic persistent hepatitis (CPH), 39 with chronic active hepatitis (CAH) and 23 with liver cirrhosis (LC). The results showed a clear relationship between the incidence of CIC and the presence of HBsAg in the patients with persistent or active chronic hepatitis but not in those with liver cirrhosis. The presence of HBsAg was detected in the composition of CIC in only part of the cases (10/25 patients). This low incidence suggests that in chronic hepatitis other antigens can also participate in the formation of CIC.

Antigen-Antibody Complex↗