Effects of the salivary glands active principle (parotin) on the bone healing of alloxan diabetic rats.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to D Teixeira.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
This work was carried out in order to investigate the influence of parotid glands on the metabolism of carbohydrates in the rat. The animals were selected by age (10, 20, 30 and 40 days-old) and distributed in 3 experimental groups as follows: Group I -- Parotidectomized animals; Group II -- Sham-parotidectomized animals; and Group III -- Control animals. The animals from all the groups were sacrificed 20 days after the beginning of the experiment. From the discussion of the results it was observed that the parotidectomized animals at 20, 30 and 40 days have presented significantly larger glycaemic means than control animals. These control animals, by the other hand, have also presented significantly larger glycaemic means than sham-parotidectomized animals. Concerning the 10 days-old animals, the statistical analysis have not showed any significance among the three groups. The results obtained from hepatic glycogen dosages, in the same animals, have showed a coherence, because the animals that have presented larger glycaemic levels, have also presented less hepatic glycogen content; contrarily, the animals that have presented a less glycaemic levels, have also presented a larger amount of hepatic glycogen.
Differences in neurocranium growth at puberty were studied in rats of both sexes thymectomized and sham-thymectomized at 2, 4, 6, 8, 10, 12 and 14 days of age and in controls of matched age and sex; skull length, width and height, and skull base length and face length were measured. The neurocranium of the thymectomized rats was significantly smaller than that of the sham-thymectomized and control rats of both sexes and in all age-groups.
The authors studied the relationship between thymus and growth of long bones in rats in the pre-puberal stage. 150 rats of both sexes were divided in 3 groups: thymectomized, sham-thymectomized and controls. The animals were sacrificed 15 days after surgery, the femurs were collected and measured, in length and breadth. Thymectomized animals have a bone growth significantly lesser in length and breadth when compared to the sham-thymectomized animals. The latter ones also presented a lesser bone growth when compared to the controls. The average body weight was also significantly lesser in thymectomized rats than in controls, the same happening with the shamthymectomized rats. It is suggested that the thymus probably presents some kind of relation with the hypothalamus through a positive feed-back, simulating secretion of substances that would act on the adenohypophysis rising the secretion of growth hormone and the thymus playing a role in maintaining the serum levels of growth hormone and thyroxine necessary for the growth and development of bones.
A study was made concerning the effects of sialoadenectomy and parotin hormone administration upon sponge-induced granulation tissue of young adult rats. The effects of sialoadenectomy alone and sialoadenectomy plus a single subcutaneous injection of parotin hormone, in two different doses (0.15 and 0.30 mg), on the development of 15-day-old granulation tissue were observed. The action of parotin hormone administration without sialoadenectomy was also investigated. The results have shown that sialoadenectomy produces a retardation effect upon the development of the tissue. This effect was partially inhibited by 0.15 mg and totally eliminated by the administration of 0.30 mg of the hormone. When administered in rats which were not sialoadenectomized, the dose of 0.30 mg caused increased fibroplasia and vascularization of granulation tissue, while a dose of 0.15 mg did not cause any significant difference when compared to the control tissue.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.