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Biomedical subjects

D Tennstedt

Publications and source records attributed to D Tennstedt.

At least 19 recordsLinked to original sources
PubMed1992

Intraepidermal neutrophilic IgA dermatosis: pemphigus-like IgA deposits.

A case of intraepidermal neutrophilic IgA dermatosis with intercellular IgA deposit in the upper epidermis is reported. Indirect immunofluorescence was negative but immunoelectrophoresis showed a slight increase of IgA. The chemotactic activity of neutrophils was normal. Colchicine controlled the lesions.

Epidermis↗
PubMed1992

Itraconazole compared with griseofulvin in the treatment of tinea corporis/cruris and tinea pedis/manus: an interpretation of the clinical results of all completed double-blind studies with respect to the pharmacokinetic profile.

Itraconazole is an orally active triazole antifungal which has been compared to griseofulvin in a number of double-blind trials. In dermatophytosis with a non-fixed treatment regimen for a maximum of 3 months, itraconazole 100 mg o.d. has produced a 100% mycological cure rate as compared with a 67% rate with griseofulvin 500 mg o.d. (p less than 0.01). Based on the pharmacokinetic profile, 100 mg itraconazole daily was then compared with 500 mg ultramicronized griseofulvin daily using a fixed treatment schedule of 15 days in tinea corporis and/or cruris and 30 days in tinea pedis and/or manus. In all studies in tinea corporis/cruris (n = 277), the superiority of itraconazole was shown for the clinical outcome at the last follow-up visit 2 weeks post-therapy (88 vs. 69%, p less than 0.01) and in the mycological outcome at the last follow-up visit (81 vs. 65%, p less than 0.05). In tinea pedis/manus (n = 210), the clinical response was virtually the same for the two treatment groups, but the most important finding was the mycological outcome with a significantly better result in favor of itraconazole at the end of treatment (77 vs. 61%, p less than 0.05) even more pronounced at the follow-up visit (85 vs. 48%, p less than 0.01). We conclude that itraconazole 100 mg daily in the treatment of tinea corporis/cruris and in tinea pedis/manus is significantly more effective than 500 mg griseofulvin daily when fixed treatment regimens are used. Furthermore, the best results are obtained with itraconazole 2-3 weeks after the end of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria.

Loratadine is a new selective peripheral histamine H1-receptor antagonist, that is orally effective, long-acting, and devoid of significant central and autonomic nervous system activity. Its safety and efficacy were evaluated in a 28-day study conducted in patients with chronic idiopathic urticaria. Patients were randomly assigned to one of three treatment groups (loratadine, 10 mg OD; terfenadine, 60 mg BID; or placebo). Evaluation of efficacy included weekly assessments of the individual disease signs and symptoms, the overall disease condition, and therapeutic response to treatment. Throughout the 28-day treatment period progressive improvement was observed in the loratadine and terfenadine treatment groups; however, at each evaluation, loratadine was significantly more effective than placebo (P less than .01) and clinically more effective than terfenadine in reducing disease signs and symptoms. Terfenadine was significantly more effective than placebo at day 7 and endpoint (last valid visit). The overall therapeutic response at the endpoint of treatment was rated as marked or complete relief of symptoms in 64%, 52%, and 25% of the patients in the loratadine, terfenadine, and placebo treatment groups, respectively. Loratadine was well tolerated and comparable to terfenadine and placebo in incidence of adverse experiences. Sedation was reported in one patient each in the terfenadine and placebo treatment groups and an anticholinergic side effect (dry mouth) in one terfenadine-treated patient. No sedative or anticholinergic side effects were observed in patients receiving loratadine. We concluded that loratadine, 10 mg, once daily is a safe and effective treatment for symptomatic relief of chronic idiopathic urticaria.

Adolescent↗
PubMed1990

[Juvenile plantar dermatosis: when are epicutaneous tests indicated?].

The aetiology of juvenile plantar dermatosis (JPD) is probably multifactorial. Atopy, frictional factors and the frequent alternation between a hot and wet microclimate and a dry one seem to favour the dermatosis. An allergic contact dermatitis does not only involve a difficult differential diagnosis; it can also cause secondary deterioration of existing JPD. For these reasons, an attempt is made in this paper to specify the situations in which patch tests are indicated.

Child↗
PubMed1989

Contact sensitivity to nonoxynols as a cause of intolerance to antiseptic preparations.

Twelve cases of allergic contact dermatitis caused by antiseptic preparations are presented. The reactions resulted not from the active principles but rather from nonoxynols used in the offending substances as nonionic surface-active agents. Nonoxynols are ethoxylated alkyl phenols or nonylphenylethers that conform in general to the formula C9H19C6H4(OCH2CH2)nOH. They have emulsifying, wetting, foaming, and solubilizing properties and are used in a large number of industrial, household, agricultural, cosmetic, and pharmaceutical products. They also are used as spermicides. There are very few reports in the literature of skin problems caused by nonoxynols.

Adult↗
PubMed1989

Contact dermatitis from topical imidazole antifungals: 15 new cases.

Contact allergy from topical imidazole antifungals is seldom reported. 15 such cases, over a 12-year period, are reported here. Results are discussed particularly with regard to imidazole cross-reactions and to sensitization to topicals combining miconazole and hydrocortisone.

Adolescent↗
PubMed1988

Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles.

In recent years, we have observed several "ring-shaped" positive allergic patch test reactions to allergens dissolved in a liquid vehicle, a more intense response at the periphery of the site of application than in the central part. The occurrence of such reactions was evaluated for formaldehyde, Kathon CG, hydrocortisone and hexamidine diisethionate. Possible explanations for such reactions include pressure and/or a capillary effect.

Allergens↗
PubMed1987

Skin granulomas due to Mycobacterium gordonae.

A 38-year-old woman presented with small, ulcerated, red or bluish nodules on the right hand, clinically resembling mycobacterial granulomas; these appeared a few months after a bite by a rat, while the patient was collecting frogs in a pond in the Belgian Ardennes. The histopathologic picture was compatible with a diagnosis of mycobacterial infection and rare acid-fast bacilli could be found. Repeated bacteriologic investigations were performed and these led to the identification of a strain displaying characteristics of Mycobacterium gordonae. The skin condition responded well to rifampicin (300 mg/day) within 6 months.

Adult↗
PubMed1986

Imidazoles and benzoyl peroxide: a comparative trial of two treatment schedules.

A double-blind, split-face, self-controlled pilot trial was designed for comparing the therapeutical effect of (a) combination of 2% miconazole nitrate and 5% benzoyl peroxide applied twice daily and (b) topical application of 1% isoconazole nitrate in the morning followed in the evening by 5% benzoyl peroxide. There were no clinically relevant differences between both treatment regimes. These results are interpreted in terms of bioavailability of the active substances.

Acne Vulgaris↗
PubMed1985

Juvenile plantar dermatosis: a report of 80 cases.

Juvenile plantar dermatosis (JPD) is a skin disease found mainly in children between the ages of 3 and 14 years old. External factors having a role in the development of the disease include: mechanical trauma, occlusive footwear (shoes and socks), and perhaps the seasons of the year. Data on gender, seasonal patterns, and listing of atopy are presented for 80 consecutive cases of JPD.

Adolescent↗