Changes in intestinal slow wave propagation velocity during the estrus cycle in the cat.
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Animals↗
Biomedical subjects
D Terasaka
Publications and source records attributed to D Terasaka.
Postprandial changes in intestinal slow-wave propagation reflect a decrease in cell coupling.
The purpose of these studies was to determine the effects of feeding on jejunal slow-wave propagation velocity (SWPV). Nine cats were instrumented with six pairs of electrodes implanted 4 cm apart on the jejunum. Electrical activity was recorded at the end of an 18-h fast after which each animal was fed 60 g of canned cat food. Recordings were continued during feeding and for several hours thereafter. This procedure was repeated at least twice for each cat. Average SWPV (cm/s) decreased from a fasting level of 2.28 +/- 0.20 (mean of means +/- SE) to 1.93 +/- 0.16 at 10-20 min, 1.51 +/- 0.11 at 1 h, and 1.37 +/- 0.10 at 3 h postprandially. Corresponding SW frequencies (SWFs) were 19.6 +/- 0.3, 18.7 +/- 0.2, 19.2 +/- 0.2, and 19.0 +/- 0.2 cycles/min, respectively. The differences between the fasting SWPV and that at 1 and 3 h were significant (P less than 0.05). When SWPV was plotted as a function of SWF, the slopes of the corresponding curves were also found to decrease postprandially (P less than 0.05, fasting vs. 1 and 3 h). There was no apparent change in SW amplitude, maximum rate of SW depolarization, or threshold. In the absence of changes in these parameters, the divergence of the slopes at lower SWFs indicates that the decrease in SWPV is because of increased internal resistance, probably the result of uncoupling of intestinal muscle cells. The change is rapid in onset and long in duration, suggesting that an uncoupling factor is released during ingestion of a meal, and that its effect persists for several hours.
Animals↗
Free fatty acids of human meconium.
Meconium samples of 20 healthy full-term babies were analyzed for free fatty acid content. The total fatty acid content per net weight varied by as much as 9-fold between samples. Considerable variability was also observed in the individual fatty acids found in each sample. Palmitic, stearic and oleic acids were the most abundant fatty acids. Significant amounts of arachidonic and linoleic acids were found. Long-chain iso fatty acids, which are rare in mammalian tissue, were found. The source of these fatty acids is unknown, but intestinal lipases and transplacental origins may be important.
Fatty Acids, Nonesterified↗