PubMed Health⌕ Search

Biomedical subjects

D Theilade

Publications and source records attributed to D Theilade.

8 recordsLinked to original sources
PubMed1999

Edta chelation therapy: an ethical problem.

The randomized, double-blind study is generally regarded as the ideal standard of clinical drug trials, but uncritical blinding in clinical studies should be questioned (1,2). Most often, the method of randomization is not sufficiently described. There are examples of researchers having used opaque envelopes or opened several envelopes or X-rayed the envelopes. Violation of the randomization is unfortunately common (3). New guidelines for structured reporting of clinical trials with focus on the randomization method have been worked out (4). However, other methods of violation of the randomization have not been covered in the new guidelines. In a claimed double-blind multi-center study, isotonic Na2 ethylenediaminetetraacetic acid (edta) solution as verum and isotonic saline as placebo was used without any problem with the blinding. In the multi-center study, only nine incidents of burning at the infusion site were registered out of a total of more than 1000 Na2edta infusions (5). In our study, a total of 10 persons were given exactly the same kind of infusions and nine out of 10 receiving Na2edta infusions reacted with burning at the infusion site, thus proving it impossible to use Na2edta versus saline and maintain the blinding in a study of double-blind design. The difference in painful reactions between the Na2edta group and the saline group at the infusion site is statistically significant (P<0.001).

Adult↗
PubMed1978

Nasal CPAP employing a jet device for creating positive pressure.

A nasal CPAP system consisting of a jet device (weight 5 g) connected with a binasal nose-piece is described. A positive airway pressure is obtained with the system applied to newborn infants provided a certain magnitude of air is brought to the jet device, and a resistance, presented by the airways, exists against the flow of air. As the system requires neither a manometer nor an excess pressure safety valve, pressures in the nasopharynx were recorded at various jet flows to illustrate the flow/pressure relationship. The CPAP can easily be etablished at definite pressures by simple adjustment of the jet flow, using this flow/pressure curve. The system appeared efficient for the treatment of apnoea, apparently due to a special attribute of the jet device. Oesophageal pressures were measured at various gas flows and at various stages of RDS, and in children with healthy lungs. The pressure appeared high with increased density of the lungs, but constant in healthy lungs despite various gas flows. Extreme pressure excursion were recorded during crying and increased muscular tone. This may explain the high frequency of pneumothorax in RDS.

Child↗
PubMed1978

Nasal CPAP treatment of the respiratory distress syndrome: a prospective investigation of 10 new born infants.

Ten newborn infants with the idiopathic respiratory distress syndrome (IRDS) or foetal aspiration (FA) were treated with a simplified nasal CPAP system (continuous positive airway pressure). The system consists of a Hudson binasal cannula and a Benveniste pediatric jet device (weight 5 g). The desired airway pressures are obtained by adjustment of the jet flow in accordance with the naso-pharyngeal flow/pressure relationship. The system was found to be effective in the treatment of 9 of the 10 children, as demonstrated by improved blood gas values, and improved respiration; the latter was also evident in infants with pronounced apnea. In one child pneumothorax, occuring after about 24 hours of successful CPAP treatment, necessitated respirator treatment. The system is quick and simple to use, and permits feeding, lung physiotherapy and routine nursing of the child during treatment.

Apnea↗
PubMed1977

The danger of fatal misjudgement in hypothermia after immersion. Successful resuscitation following immersion for 25 minutes.

A case is reported of the successful resuscitation of a 6-year-old child after 25 minutes' immersion in water at 4 degrees C. The difficulties of evaluating vital functions at low body temperatures, with the accompanying danger of fatal misjudgment, are pointed out. It is concluded that low body temperatures indicate that a considerably longer resuscitation procedure than normal should be undertaken, particularly in children, and that if the body temperature is above 30 degrees C rewarming ought not to take place before satisfactory oxygenation and an efficient circulation have been established.

Child↗
PubMedDate not supplied

Nasal continuous positive airway pressure in the treatment of whooping cough.

A 3-week-old baby, suffering from whooping cough with severe attacks of apnoea and hypoxia, was treated by nasal CPAP with a positive airway pressure of about 5 cm H2O. The respiration improved rapidly and the transcutaneous oxygen tension increased to a normal level. The treatment was carried on for 7 days and discontinued gradually in the course of 3 days. The child was also treated with pertussis immunoglobulin and erythromycin. The CPAP system employed is easily and rapidly applied and allows normal nursing of the child during the treatment and manual lung physiotherapy in upright position. The treatment probably proved lifesaving.

Apnea↗