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D Thrush

Publications and source records attributed to D Thrush.

14 recordsLinked to original sources
PubMed1997

Young people's representations of others' views of smoking: is there a link with smoking behaviour?

This paper reports a large-scale survey (n = 1985) of 9-12-year-olds' representations of parents' and friend's views about the nature of smoking. Taking the perspective of Social Representations theory, consensual representations of respondents' views of significant others are identified using cluster analysis without reference to smoking behaviour. Resulting clusters of individuals map on to self-reported behavioural groups at above chance level. These relationships indicate young smokers have access to sets of beliefs about others' smoking views that may differ systematically from those available to nonsmokers. This suggests an additional social psychological mechanism that may be implicated in early onset of smoking in adolescence.

Child↗
PubMed1995

Continuous thermodilution cardiac output: agreement with Fick and bolus thermodilution methods.

OBJECTIVE: Cardiac outputs were determined with continuous thermodilution, bolus thermodilution, and the Fick method during pharmacologically varied hemodynamics. DESIGN: Prospective comparison of techniques. SETTING: University animal laboratory. PARTICIPANTS: Swine. INTERVENTIONS: Swine were anesthetized, tracheally intubated, and instrumented to measure continuous (QTDC) and bolus (QTDB) thermodilution cardiac outputs and sample arterial and mixed venous blood. Continuous thermodilution of blood was facilitated by computer modulation of a thermal filament wrapped around the portion of the pulmonary artery catheter residing in the right atrium and ventricle. QTDC was computed from the thermodilution curve monitored by the thermistor. Bolus thermodilution was performed in triplicate by injecting 10 mL of 5% dextrose in water (0 to 4 degrees C). Oxygen consumption (VO2) was calculated as the averaged minute rate of disappearance of spirometer oxygen over a 6-minute steady state. Cardiac output was determined with the direct Fick method (QF) by dividing VO2 by the difference in arterial and mixed venous oxygen content. Basal QTDC was increased and decreased with an intravenous infusion of dobutamine or labetalol, respectively. Data are summarized as mean +/- SD or 95% confidence interval (CI 95%). Agreement between methods of determining cardiac output was assessed by calculating bias, percent bias, and percent coefficient of determination (100 r2). MEASUREMENTS AND MAIN RESULTS: Eighteen swine (38.9 +/- 1.2 kg) exhibited a range of QTDC from 2.2 to 14.8 L/min. Mean measurement variance of VO2, CaO2, CvO2, and QTDB was 1.5%, 1.5%, 2.0%, and 11.8%, respectively. Mean bias, percent bias, and 100 r2 was 0.004 +/- 1.05 L/min (CI 95%: 0.18 to 0.19 L/min), -0.37 +/- 13.8% (CI 95%: -2.75 to 2.01), and 89% between QTDC and QF, respectively. Bias, percent bias, and 100 r2 was 0.05 +/- 1.09 L/min (CI 95%: -0.14 to 0.23 L/min, 1.21 +/- 13.06% (CI 95%: -1.03 to 3.46%), and 91% between QTDC and QTDB, respectively. Bias, percent bias, and 100 r2 (Fig 6) was -0.04 +/- 0.69 L/min (CI 95%: -0.16 to -.08 L/min), -1.23 +/- 9.17% (CI 95%: -2.8 to 0.35%), and 94% between QTDB and QF, respectively. CONCLUSION: Automatic cardiac output computed with continuous thermodilution appears accurate and reliable. Also, good agreement was confirmed between cardiac output derived by continuous and bolus thermodilution methods and bolus thermodilution and Fick methods.

Adrenergic Agonists↗
PubMed1995

Progressive neuronal degeneration of childhood with liver disease (Alpers' disease) presenting in young adults.

Two unrelated and previously healthy girls, aged 17 and 18, presented with a subacute encephalopathy, visual and sensory symptoms and signs, and prominent seizures that were difficult to control. Brain MRI showed lesions (high signal on T2 weighted images) in the occipital lobes and thalamus; EEG showed slow wave activity with superimposed polyspikes. Inexorable downhill progression led to death in hepatic failure within eight months of onset. Histopathological findings in both patients ((a) chronic hepatitis with prominent bile duct proliferation, fatty change, and fibrosis; (b) in the brain a patchy destruction of the cerebral cortex, predominantly involving striate cortex) were characteristic of progressive neuronal degeneration of childhood with liver disease--Alpers-Huttenlocher syndrome--a rare autosomal recessive disorder usually seen in infants and young children.

Adolescent↗
PubMed1994

Accuracy of pulse oximetry during hypoxemia.

To determine the accuracy of four pulse oximeters during mild and moderate arterial hypoxemia, we produced stepwise arterial blood desaturation in 25 healthy, nonsmoking volunteers by adjusting the inhaled oxygen concentration. At plateaus of < 80%, 85% to 90%, 90% to 95%, and 95% to 100%, pulse oximetry saturation (SpO2) was measured with the four different monitors: Dinamap Plus Model 8700, Oxyshuttle, Ohmeda 3700, and MiniOx IV. Arterial blood samples were analyzed with a co-oximeter and the arterial oxyhemoglobin saturation (SaO2) was compared with the SpO2 readings at each plateau. Significant deterioration in the accuracy of pulse oximeters was observed as SaO2 decreased. In 14 instances of hypoxemia (SaO2 < 90%), subjects exhibited SpO2 values greater than 90%. In conclusion, the accuracy of pulse oximetry deteriorates as hypoxemia worsens. Confirmation of arterial blood oxyhemoglobin saturation by co-oximetry is necessary when precise determination of arterial oxyhemoglobin level is critical.

Adult↗
PubMed1994

Acute ataxic neuropathy with cross-reactive antibodies to GD1b and GD3 gangliosides.

We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness, with transient, high-titer serum IgG antibodies to a single NeuAc(alpha 2-8)NeuAc-linked disialosyl epitope, as found on GD1b and GD3 gangliosides. The serum did not react with GQ1b, GT1a, or GT1b. This atypical case, which most closely represents an incomplete Miller Fisher syndrome, indicates that anti-GD1b/GD3 antibodies may be able to induce sensory ataxia.

Adult↗
PubMed1987

X-linked bulbo-spinal neuronopathy: a family study of three patients.

The clinical features of two brothers and one nephew with X-linked recessive bulbo-spinal neuronopathy are described. The neurophysiological investigations and sural nerve biopsy, previously unreported, confirmed that both motor and sensory nerves are affected. Because of the genetic implications, the importance is stressed of recognising this disorder as a separate entity which should not be classified with the spinal muscular atrophies.

Adult↗
PubMedDate not supplied

Investigation of peripheral neuropathy.

Much exciting work has been carried out on the peripheral nervous system during the past 20 years and has led to a greater understanding of peripheral nerve disorders and to improved diagnosis and treatment. This article sets out a systematic approach to the diagnosis of the patient with peripheral neuropathy.

Axons↗