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Biomedical subjects

D Touitou

Publications and source records attributed to D Touitou.

15 recordsLinked to original sources

[Value of bone angioscintigraphy (isotope transit) in atraumatic osteonecrosis of the head of the femur].

Bone angioscintigraphy (isotopic transit) imaging provides a time-activity curve of two symmetrical joint regions (one of which is supposedly diseased) during the first few seconds following radioisotope injections, in this case 99mTc MDP. The curve obtained presents as two parts: a short rapid slope corresponding to the presence of the marker in the arteries of the region, and a slowly ascending slope corresponding to invasion of capillary bed without extravascular diffusion during the first minute. This method was used to study 22 cases of confirmed unilateral osteonecrosis of hip. In 20 of the 22 cases the height of the curve differed from one side to another: lower on the diseased side in 9 cases (negative gradient), 8 of these 9 patients having stages I and II (early stages) of the affection. It is suggested that this reduction in activity of the diseased side is due to a reduction in capillary bed from medullary necrosis, and that it constitutes a sign in favor of necrosis, particularly when radiologic signs are few or absent as in the early stages.

Adult↗

[Isotope transit in reflex sympathetic algodystrophy].

It has been shown in radioisotope scans made three hours after injection of 99mTc MDP that a significant hyperfixation in bone extremities is present in causalgias, probably due to accelerated osteogenesis. However, this gives no information concerning blood circulation inside bone. Nevertheless, the kinetic activity of tracer in areas of lesion for the initial seconds after injection depends upon the vascularity of this region. The computerized recording of isotope activity forms an early activity curb (isotope transit) which can be compared to the activity curb of the corresponding healthy articulatory region of the other limb or side. This curb breaks down into two parts: first, a rapidly ascending slope that corresponds to infiltration of the periarticular arterial network; second, a slowly ascending slope that corresponds to the tracer diffusion space in bony extremities. Among the 27 cases of causalgia in our series 19 evolved into thermalgias in less than three months. Furthermore, in 18 of these 19 cases the lesion-side activity curb was significantly different from the aspect of the healthy side's curb in that both portions showed a hyperactivity. The initial "arterial" hyperactivity slope probably corresponds to an increase in arterial blood flow (and sometimes circulatory speed) in soft tissues around joints; subsequent hyperactivity, gradually increasing, probably corresponds to an increase in the vascular bed volume and diffusion surface due to functional entry of usually silent intraosseous capillaries. Thus, the causalgia which has become thermalgic has a typical initial isotopic tracing curb: this hyperfixation explains the anatomic and pathophysiologic disorders evidenced by other procedures in this disease.

Adolescent↗

[Diffuse superficial nephroblastomatosis. Chemotherapy. 1 case].

A case of superficial diffuse nephroblastomatosis involving both kidneys in a 14-months old child is reported. Urographic and arteriographic results as well as the still little-known ultrasonographic images made it possible to determine pre-operatively the nature of the tumour and to exclude the initial diagnosis of Wilm's tumour. A relatively non-aggressive chemotherapy resulted in complete involution of the subcapsular tumoral envelope. The close embryogenic and oncogenic relationship between nephroblastoma and nephroblastomatosis is recalled.

Dactinomycin↗

[Computer tomography in children (author's transl)].

The determination of the density of a lesion is important in infant computer tomography. The authors show examples of hematomas, tumors and pericerebral collections, as well as the experimental determination of the density of the CSF with increasing protein content.

Adolescent↗

[Tomodensitometry of hydatid brain cysts in a child].

A case of an eleven year old boy with an intracranial hydadid cyst is reported. The characteristics of computerised tomography of the skull are described, and differential diagnosis of other cystic space occupying lesions of the brain as seen on computerised tomography is discussed.

Absorptiometry, Photon↗

[Computed X-ray tomography in cases of metastatic brain tumors].

The authors describe the role of computerized tomography in the diagnosis of metastases to the brain and orbit, and analyse computer tomography findings in different types of metastases. Because the metastases are visualized better after administration of contrast medium the importance of this tomography done before and after administration of contrast medium is discussed.

Adult↗