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Biomedical subjects

D Trifonov

Publications and source records attributed to D Trifonov.

At least 19 recordsLinked to original sources
PubMed2004

[Micrometastases in patients with colorectal cancer: markers for metastatic potential or proofs for residual disease].

It is know that bone marrow micrometastases are an indicator of poor prognosis in patients with epithelial tumors. At the same time little is known if they reflect minimal residual disease or cells distribution and marked metastatic potential. We aimed to perform a clinical study, which though with little gathered clinical material has a direction--investigation of bone marrow in patients with colorectal cancer by the time of surgery, carefully rendering an account of staging and performing curative resection. In intraoperatively done bone marrow biopsy with following investigation for cytoceratin 19 positive cells we found ol presence of metastatic cells in some the studied patients. Finding micrometastases in patients with colorectal cancer is a marker for more agressive course of the disease and for the need to change some of recent methods of treatment.

Biomarkers, Tumor↗
PubMed2003

[A new approach for discovering minimal residual disease in patients with operable breast cancer].

The striving of surgeon for achieving better long-term results of surgical treatment of patients with breast cancer put the searching of new independent prognostic factors for the exit of the treatment. This has become possible in the last decade of XX century when new diagnostic methods as immunochistochemistry, polimerase chain reaction (PCR), cytomorphology etc. entered the clinical practice. With bone marrow biopsy in patients with breast cancer earlier diagnosis of minimal residual disease is achieved, the approach to those patients is changed and a possibility for discovering women at higher risk is given. By immunochistochemistry method in the diagnostics of minimal residual disease in patients with breast cancer, more precise staging is achieved. This will change the therapeutic approach to these patients.

Biopsy↗
PubMed2003

[A case of dermatofibrosarcoma in 27 year old patient].

A case of dermatofibrosarcoma protuberans of the trunk involving the underlying soft tissue and muscle fascia, in early stage of development in 27 year old patient, operated by taking safety margin of 3 cm and the underlying muscle fascia, is being reported. Modality of treatment has been discussed.

Adult↗
PubMed2000

[Diagnosis and surgical treatment of adrenocortical carcinoma. A review of the literature and report of two cases].

Adrenocortical carcinomas (ACC) are rare and represent only 0.05 to 0.2% of all cancers. They can be hormonally active, appearing clinically by one or more endocrine syndromes, or can be hormonally non-active. Commonly most of the cases with AC are diagnosed when the neoplastic process have spread out of the suprarenal gland (stage III or IV). Computed tomography and magnetic resonance imaging are the most useful diagnostic methods of ACC but the latter is more accurate, especially in estimation of the local invasion of the tumor. Surgery is the main and the most effective method for treatment of both primary and recurrent ACC, and in selective cases--of metastasis. The chemotherapy with mitotane has a limited role and is indicated in cases of inoperable ACC (primary or recurrent) and/or presence of metastasis. Two cases of ACC treated in our department are reported. Case I: a 26-years-old female with ACC in stage II, which was diagnosed incidentally by ultrasound investigation for other consideration. Although the urine levels of free cortisol were elevated, the woman had no endocrine symptoms. Case II: a 50-years-old female with a second recurrence ACC appeared 5 years after a resection of the first recurrence tumor and 6 years after an operation for the primary tumor. Problems in diagnose and surgical treatment of these cases are discussed.

Adrenal Cortex Neoplasms↗
PubMed1998

[Phyllodes tumors of the breast].

Phyllodes tumors are mixed tumors of the mammary gland. They account for 0.3 to 0.5 per cent of all breast tumors. This is a report on nineteen cases presenting phyllodes tumors. Depending on the number of mitoses, growth pattern and atypism degree, the neoplasms are classified as benign (12 cases), borderline (2) and malignant (5). Fourteen of them (9 with benign and 5 with malignant phyllodes tumors) undergo clinical follow-up study. A case with bilateral location of the neoplasm exhibiting strongly expressed susceptibility to relapse is described. The basic methods of preoperative diagnosis and the operative treatment procedures used are outlined.

Adolescent↗
PubMed1989

[One-step breast reconstruction].

The mental trauma induced by removal of the mammary gland for cancer may be overcome by reconstruction of the breast. One-step reconstruction applied on 4 patients showed considerable advantages over a postponed reconstruction: technically it is easier to perform; a single stay of the patient in hospital makes it cheaper. It is no obstacle to perform pre- and postoperative radio- and chemotherapy. According to available data in the literature, implanted prosthesis or transposed flap do not veil a local relapse.

Adult↗