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Biomedical subjects

D Trimble

Publications and source records attributed to D Trimble.

5 recordsLinked to original sources

Making sense in conversations about learning disabilities.

This article describes an integrative, multisystem clinical approach to the psychological and relational problems that develop around learning disabilities. Positioned in relationships with children, families, and schools, the therapist addresses the emotions, interpersonal conflicts, and problematic beliefs that contribute to problems. Using clinical skills to contain and relieve painful emotions, the therapist soothes "inflammation at the boundaries" of relationships among children, families, and schools, depolarizing conflicts within and between systems. Familiar with developmental and educational psychology and developmental neurobiology, the therapist makes this specialized knowledge intelligible to children, families, and teachers. This article describes two specific methods, the chart of strengths and weaknesses and the map of learning functions, which facilitate communication of specialized knowledge about children with learning disabilities. The therapist uses expert knowledge to help members of the treatment system transform blaming, helpless, or hopeless interpretations of the problem into more hopeful constructions, which support healthy development.

Adolescent↗

Factors contributing to troponin exchange in myofibrils and in solution.

The troponin complex in a muscle fiber can be replaced with exogenous troponin by using a gentle exchange procedure in which the actin-tropomyosin complex is never devoid of a full complement of troponin (Brenner et al. (1999) Biophys J 77: 2677-2691). The mechanism of this exchange process and the factors that influence this exchange are poorly understood. In this study, the exchange process has now been examined in myofibrils and in solution. In myofibrils under rigor conditions, troponin exchange occurred preferentially in the region of overlap between actin and myosin when the free Ca2+ concentration was low. At higher concentrations of Ca2+, the exchange occurred uniformly along the actin. Ca2+ also accelerated troponin exchange in solution but the effect of S1 could not be confirmed in solution experiments. The rate of exchange in solution was insensitive to moderate changes in pH or ionic strength. Increasing the temperature resulted in a two-fold increase in rate with each 10 degrees C increase in temperature. A sequential two step model of troponin binding to actin-tropomyosin could simulate the observed association and dissociation transients. In the absence of Ca2+ or rigor S1, the following rate constants could describe the binding process: k1 = 7.12 microM(-1) s(-1), k(-1) = 0.65 s(-1), k2 = 0.07 s(-1), k(-2) = 0.0014 s(-1). The slow rate of detachment of troponin from actin (k(-2)) limits the rate of exchange in solution and most likely contributes to the slow rate of exchange in fibers.

Actins↗

Assessing support and stress in the social networks of chronic patients.

The social support network of deinstitutionalized chronic mentally ill patients can help moderate life stresses and reduce the need for rehospitalization. The authors have developed a list of questions that can be used in assessing the various characteristics of a patient's social network, including the number of people in the network, the types of roles assumed in each relationship, and the nature of behavioral exchanges in each relationship. They believe that research on the social networks of chronic patients may provide information that will lead to more effective intervention.

Adult↗

Age differences in responses to facial trauma.

This study examines age differences in causes, characteristics, and outcomes of facial trauma seen in a major trauma hospital. A retrospective analysis was undertaken of 615 cases of facial trauma that had occurred during a 5-year period. The greatest proportion of patients were aged 20 to 29; those older than age 60 represented just 6.8% of the total cases. Gender differences were not observed in the oldest age groups. The oldest patients (older than 70 years) were more likely to have had pedestrian accidents and less likely to have been assaulted than other age groups. Older patients had more multiple injuries but fewer treatment procedures than other age groups. Significant differences were found in death rates; the older patients were more likely to die as a result of their injuries. Implications for patient management based on age and treatment needs are discussed.

Accidental Falls↗