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Biomedical subjects

D Tripodi

Publications and source records attributed to D Tripodi.

At least 37 records · Page 2Linked to original sources
PubMed1992

Impact of dual-chamber permanent pacing in patients with obstructive hypertrophic cardiomyopathy with symptoms refractory to verapamil and beta-adrenergic blocker therapy.

BACKGROUND: Patients with obstructive hypertrophic cardiomyopathy (HCM) with symptoms refractory to drugs (beta-blockers or verapamil) are candidates for cardiac surgery (left ventricular septal myectomy or mitral valve replacement). The present study examines prospectively the ability of dual-chamber (DDD) pacing to improve symptoms and relieve left ventricular outflow obstruction in such patients. METHODS AND RESULTS: Forty-four consecutive patients with obstructive HCM who had failed to benefit from pharmacotherapy underwent treadmill exercise tests, echocardiography, and cardiac catheterization before and 1.5-3 months after implantation of a DDD pacemaker. Symptoms (angina, dyspnea, palpitations, presyncope, and syncope), New York Heart Association functional class status (1.7 +/- 0.7 versus 3.4 +/- 0.5, p less than 0.00001), and exercise durations were improved at follow-up evaluation. This was associated with significant reduction in left ventricular outflow tract gradient (38 +/- 38 versus 87 +/- 43 mm Hg, p less than 0.0001) and significant increases in cardiac output and systemic arterial pressures. Notably, when pacing was discontinued and comparisons were made in sinus rhythm, treadmill exercise durations were greater and left ventricular outflow tract gradients were less at the follow-up evaluation compared with the baseline study. CONCLUSIONS: DDD pacing is an effective alternative to surgery in most patients with obstructive HCM with drug-refractory symptoms. The beneficial effects of pacing continue to be evident when pacing is acutely discontinued.

Adrenergic beta-Antagonists↗
PubMed1992

Clinical comparison of two- and three-wavelength systems for continuous measurement of venous oxygen saturation.

OBJECTIVE: To evaluate clinically the accuracy of continuous SvO2 systems to reflect reference SvO2 values over a 24-hour period. DESIGN: Randomized clinical trial. SETTING: Six-bed cardiac surgical intensive care unit of a 540-bed federal facility. POPULATION: Sixty postoperative cardiac patients. INTERVENTIONS: Random assignment to a two- or three-wavelength continuous SvO2 catheter for postoperative SvO2 monitoring. At 4-hour intervals over a 24-hour period, mixed venous blood samples were analyzed with a reference cooximeter and compared with the monitor value of the SvO2 catheter. MAIN OUTCOME MEASURES: A reference cooximeter method to measure SvO2 in mixed venous blood; SvO2 as measured by the in-line, SvO2 catheter system. RESULTS: SvO2 measured by the three-wavelength system did not differ significantly from the reference SvO2 measurement. In contrast, SvO2 measured by the two-wavelength system was significantly lower than the reference SvO2 measurement within 4 hours of admission to the critical care unit and remained significantly lower throughout the 24-hour study period. CONCLUSIONS: The results of this clinical study confirmed a previous study in dogs, showing that SvO2 is measured more accurately by the three-wavelength continuous monitoring system.

Adult↗
PubMed1990

[Allergic rhinopathy: diagnosis and current therapy].

After discussing the causes and immunopathology of allergic rhinitis, the authors describe the most frequently used diagnostic tests, confirming the validity of PRICK TEST, PRIST, RAST, and TNP. As for treatment, they stress the special importance of vaccines for specific therapy and of drugs such as ketotifen and sodium cromoglycate for aspecific rhinitis and for those forms which have not benefited from vaccination.

Adolescent↗
PubMed1990

[Peripheral vertigo syndromes: diagnosis and practical therapy].

The purpose of the present paper was above all to render the subject clear and simple to understand, in view of its evident scope. In the section concerning internistic vertigo, the importance of elements and parameters that are fundamental for clinical practice was stressed particularly, in order to ensure adequate diagnostic orientation. As for the section dealing with cases of ENT interest, the syndromes most frequently observed in clinical practice have been illustrated.

Humans↗
PubMed1989

[Minor cranial injury: clinical, audiovestibular and medico-legal aspects].

Minor cranial trauma is a common pathology upon which there is no general agreement. This is why the verification and quantification of the damages should not depend on the analysis of subjective data and objective elements which are not quantifiable. By careful clinical and instrumental examination of 42 patients, the authors come to the conclusion that ENG and ABR can often provide objective and documentable data of clinical and forensic relevance.

Adolescent↗
PubMed1989

[Considerations on composite odontoma].

Odontoma in most cases presents in the mixed dentition period and can remain for long unrecognised. Asymptomatic during its long latency period, odontoma gives signs of life only in an aspecific way: the absence in the arch of one or more teeth should direct the clinician towards investigations which make it possible to identify the cause, as this may be due to odontomas. Radiography may clearly point to the presence of this lesion and may direct the operator towards surgical/orthodontic treatment so as to restore to the dental arch a tooth that would otherwise have remained included. It is, furthermore, important to remove the lesion, even though it is quite benign, because it is easily subject to septic complications. It should be recalled that it is always necessary to back up clinical with histological diagnosis so as to differentiate the odontoma from other lesions with different prognosis and therapy.

Adult↗
PubMed1977

Solid phase radioimmunoassay for quantitating anti-HBs in hepatitis B immune globulin.

A solid phase radioimmunoassay was used to quantitate the antibody in hepatitis B immune globulin. Polystyrene tubes coated with HBsAg were incubated with several dilutions of trace-labeled immune globulin, and the specific uptake was measure. Resulting data could be used to obtain the total antibody concentration in micrograms per milliliter as well as the intrinsic binding constant and index of heterogeneity.

Antibodies↗
PubMed1976

Effect of ragweed hyperimmune human gamma globulin on in vivo and in vitro parameters of ragweed sensitivity.

The effect of ragweed hyperimmune human gamma globulin upon in vitro and in vivo parameters of ragweed sensitivity was examined. In a double-blind study, 40 ragweed sensitive patients were divided into 2 groups and received either ragweed hyperimmune human gamma globulin (treated) or normal pooled globulin (control). Parameters of ragweed sensitivity studied before and following injections of the gamma globulin included skin test and nasal provocation end point titration, specific IgE antibody as measured by the RAST, leukocyte histamine release, total serum ragweed antibody level, and total serum IgE. Changes in measured parameters varied in both groups of patients. In the "treated" patient group, 1 wk later nasal sensitivity decreased significantly, and there was a trend toward decreased histamine release from leukocytes. No discernable effect was noted upon the other parameters. Thus, with the dosage used, the parenterally administered hyperimmune gamma globulin did not influence most measurements of ragweed hypersensitivity. The concept of this therapeutic approach might warrant further investigation.

Adolescent↗