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Biomedical subjects

D Troiani

Publications and source records attributed to D Troiani.

28 records · Page 2Linked to original sources
PubMed1976

Relations of single semicircular canals to the pontine reticular formation.

The effects of afferent vestibular impulses on single pontine reticular formation units and on a small filament of the IIIrd cranial nerve were recorded with tungsten microelectrodes in 40 curarized guinea pigs. Single-shock and repetitive electrical stimulations were applied by means of stimulating electrodes inserted bilaterally into the perilymphatic space of single ampullae of the anterior and lateral semicircular canals. The reticular unitary response consisted mainly in excitation of the resting discharge rate: most units showed vestibular convergence being affected by separate stimulation of the single four ampullae. the reticular evoked field and unitary potentials accounted for latency values ranging from 0.3 to 2.5 msec. As for the early latencies they can be interpreted as responses mediated by direct vestibulo-reticular fibres. A delimited vestibular projection field in the parameidan pontine reticular formation was not identified.

Animals↗
PubMed1975

Convergence of afferent impulses from individual semicircular canals of pontine reticular units.

The effect of afferent impulses on single pontine RF units was recorded by means of tungsten microelectrodes in 22 curarized guinea pigs followed thermic stimulation of individual semicircular canals. The labyrinthine stimulation consisted of short-lasting circumscribed heating (45 degrees C) of the canals through a silver thermode. Unitary response to labyrinthine stimulation was characterized by excitation and inhibition of rest discharge rate. Out of 86 units, 66 received bilateral labyrinthine influences responding in greatest number (20 units) to four semicircular canals. Only two units were unaffected. No significant difference in RF responses was noticed between concordant and antagonistic canals. Reticular formation units showed great degree of facilitation of response and convergence of impulses from the single six semicircular canals.

Action Potentials↗
PubMedDate not supplied

Neural discharge of medial geniculate body units and single semicircular canal stimulation.

In curarized guinea pigs, 68 neurons of the medical geniculate body (MGB) were tested with vestibular and acoustic stimulations. Single semicircular canals were stimulated thermally. Convergence of acoustic and vestibular afferences on the same MGB unit was observed. Following stimulation of the semicircular canals, activation and inhibition of urinary discharge were recorded, inhibition being predominant, while, when clicks were delivered, bursts of activity occurred. The implications of MGB in vestibular and acoustic integration are postulated.

Acoustic Stimulation↗
PubMedDate not supplied

Diazepam enhances cerebellar inhibition on vestibular neurons.

The spontaneous neuronal activity of the lateral (LVN) and the superior (SVN) vestibular nuclei was analysed before and after the intravenous (i.v.) injection of diazepam in encéphale isolé', decerebrate and cerebellectomized rabbits. The inhibition of vestibular neurons was dependent on the integrity of cerebellar connections with LVN, while these links were partially responsible for the diazepam inhibition on SVN. A role of spinal and telediemesencephalic structures was not recognized. Considering that diazepam does not increase the activity of Purkinje cells, the drug effect ought to be exerted at the level of the Purkinje cell junctions with the cerebellar nuclei and with the vestibular neurons. GABA being the neurotransmitter released by Purkinje cells evidence is provided for a diazepam potentiation of the GABAergic mechanism at the level of vestibular system.

Animals↗