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Biomedical subjects

D Uden

Publications and source records attributed to D Uden.

6 recordsLinked to original sources
PubMed1998

Topical anesthesia for pediatric lacerations: a randomized trial of lidocaine-epinephrine-tetracaine solution versus gel.

STUDY OBJECTIVE: To compare the adequacy and efficacy of anesthesia experienced with lidocaine-epinephrine-tetracaine (LET) solution versus LET gel during suturing of uncomplicated lacerations on the face or scalp in children. METHODS: Two hundred children with lacerations of the face and scalp requiring suturing were enrolled in this blinded, randomized controlled trial, in the emergency department of a university-affiliated children's hospital. After the application of anesthetic solution or gel, adequacy of anesthesia was determined before suturing. Efficacy of anesthesia during laceration repair was determined by the length of time after removal of the topical anesthetic to the first sign of discomfort that required additional anesthesia or until suture completion. RESULTS: Adequacy of initial anesthesia was equivalent between LET solution and LET gel. There was a significant difference in efficacy of anesthesia between the LET formulations. There were more patients with complete anesthesia (85% versus 76%), fewer persons with partial anesthesia (5% versus 21%), and more persons with incomplete anesthesia (9% versus 3%) in the gel group. CONCLUSION: LET gel is at least as effective as LET solution and possesses theoretical advantages for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children.

Age Factors↗
PubMed1992

Retrieval of placental blood from the umbilical vein to determine volume, sterility, and presence of clot formation.

From August 1988 to October 1989, 60 specimens of citrate-phosphate-dextrose-adenine anticoagulated blood were retrieved from the placental umbilical veins of newborns from three gestational age groups. The specimens were removed with a needle and syringe apparatus and placed directly into sterile transfusion packs. The specimens were evaluated for the volume obtained, sterility, and presence of macroscopic clots. A blood volume sufficient to provide at least one transfusion (10 mL/kg) for 87% of the premature infants studied was retrieved from the placenta. A greater blood volume per unit of birth weight was recovered from the placentas of the smaller newborns. A 12% positive culture frequency and a 7% frequency of detectable clots were identified. These rates of occurrence suggest the need for further studies to determine the origins of these complicating factors before the adoption of this technique in the clinical setting. These findings support the hypothesis that, with proper patient selection and with specimen culture and filtration, placental blood may be a viable option for the autologous transfusion of sick, premature infants.

Blood Coagulation↗
PubMed1989

Self-regulation of salivary immunoglobulin A by children.

In a prospective randomized controlled study, the possibility that children could regulate their own salivary immunoglobulins was investigated using cyberphysiologic techniques. Fifty-seven children were randomly assigned to one of three groups. Group A subjects learned self-hypnosis with permission to increase immune substances in saliva as they chose; group B subjects learned self-hypnosis with specific suggestions for control of saliva immunoglobulins; group C subjects were given no instructions but received equal attention time. At the first visit, saliva samples (baseline) were collected, and each child looked at a videotape concerning the immune system and was tested with the Stanford Children's Hypnotic Susceptibility Scale. At the second visit, an initial saliva sample was collected prior to 30 minutes of self-hypnosis practice or conversation. At the conclusion of the experiment, a third saliva sample was obtained. Salivary IgA and IgG levels for all groups were stable from the first to the second sampling. Children in group B demonstrated a significant increase in IgA (P less than .01) during the experimental period. There were no significant changes in IgG. Stanford Children's Hypnotic Susceptibility Scale scores were stable across groups and did not relate to immunoglobulin changes.

Child↗
PubMed1987

Cervical intervertebral disc calcification in children.

Intervertebral disc calcification in children is a rare occurrence. The clinical symptoms and signs are distinctively confined to the cervical area with pain, limitation of motion, and torticollis. Long tract signs or radicular involvement are extremely unusual. CT scan and cervical spinal X-ray films shown the calcification to be in the nucleus pulposus with anterior or posterior mild protrusion into the spinal canal. Recovery without neurological sequelae is the rule in most of the pediatric cases with conservative treatment. Intervertebral disc calcification does not necessarily disappear with the onset of clinical symptoms. A case with persistent and even denser calcification at the same level of intervertebral disc space at the second episode of recurrence is illustrated.

Calcinosis↗