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D Ushiba

Publications and source records attributed to D Ushiba.

At least 19 recordsLinked to original sources

Trends of medical education in Japan.

This article introduces recent trends in medical education in Japan, from undergraduate education through continuing education, and explains changes in the number of medical schools and in the content of the curriculum. Some obstacles to the implementation of changes, particularly in undergraduate medical education, are discussed. Now that Japan has become relatively developed in the quantity of its health manpower and also socioeconomically, a change must be directed towards qualitative reorganization and rearrangement in medical education in line with the objectives posed for the new century. The establishment of something new is difficult; to change something old and established, however, is much more difficult. In Japan, while some new designs in the curriculum are found in almost all the new schools, any fundamental change in the established curriculum in the old schools can be found only rarely, and attempts at changing the established curriculum frequently encountered resistance in the old schools.

Curriculum↗

[Studies on the resistance of a congenic resistant strain of mice (DKIR) against infection with Salmonella enteritidis (author's transl)].

A congenic strain of mice (DKIR) having a relatively resistant gene for mouse typhoid was established by the beckcross mating between C3H/He and DKI strains. DKI strain is highly and uniformly susceptible to the infection with Salmonella enteritidis and C3H/He is relatively resistant to that infection. The present paper reported the consistency of resistance to Salmonella infection of DKIR strain throughout generations after 10 backcross matings. Difference of the number of infected organisms in the peritoneal fluid and organs between DKIR and DKI or C3H/He strains was also described. The newly established DKIR strain seems to be a suitable experimental animal for the study of genetical resistance for mouse typhoid when compared with its original DKI strain.

Animals↗

Characterization of "clearance" factor and "cell-bound" antibody in experimental typhoid.

Daizo, Ushiba (Keio University School of Medicine, Tokyo, Japan), Taiji Nakae, Takehisa Akiyama, and Yoshio Kishimoto. Characterization of "clearance" factor and "cell-bound" antibody in experimental typhoid. J. Bacteriol. 91:1705-1712. 1966.-The "clearance" factor produced in the serum of rabbits immunized with a killed vaccine of an S-type virulent strain of Salmonella enteritidis was identified as O agglutinin and characterized immunochemically as a class of macroglobulin with a sedimentation coefficient of 12.7S. The macroglobulin, which was isolated by means of diethylaminoethyl cellulose column chromatography and sucrose density gradient centrifugation, showed a single protein peak when subjected to cellulose acetate electrophoresis and analytical ultracentrifugation. Its activity as agglutinin and "clearance" factor was inactivated both by mercaptoethanol treatment and absorbtion with the specific O antigen. The H agglutinin was also isolated as a single globulin fraction with relatively low molecular weight, and was characterized as a 7S gamma-globulin. This fraction had no "clearance" activity. A macroglobulin, similar to that identified in the rabbit serum, was extracted with urea from the cells of mice immunized with the S-type killed vaccine, but not from mice immunized with a live vaccine (R-type mutant), although this latter vaccine is very effective in producing a solid immunity against typhoid disease. The relation of this "cell-bound" antibody to the mechanism of "cellular" immunity in experimental typhoid is discussed.

Animals↗