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Biomedical subjects

D Uthoff

Publications and source records attributed to D Uthoff.

26 records · Page 2Linked to original sources
PubMed1984

[Biometric studies on the rabbit eye].

Echographic and ophthalmometric in vivo studies concerning the axial length of the bulbus, the depth of the anterior chamber, the thickness of the lens as well as the radius and the power of refraction of the cornea were carried out on 24 eyes of 12 male inbred rabbits. In addition, in vitro studies of the bulbi were also performed with regard to the axial and equatorial length, the different diameters of the cornea, the depth of the chamber angle and the sulcus ciliaris, and the diameter of the lens. Results are shown separately for right and left eyes.

Animals↗
PubMed1979

[Immunopathogenesis of the Vogt-Koyanagi-Harada syndrome].

Regarding immunopathogenesis of the Vogt-Koyanagi-Harada syndrome (VKHS), peripheral blood lymphocytes of a female patient with this disease were tested for sensitization against several antigens such as myelinic basic protein (BP) and uveoretinal, brain and spleen tissue homogenates. For comparison, cells of seven patients with chorioretinitis only and cells of six patients with encephalitis of unknown etiology were also tested. Cells of healthy donors served as controls. The electromobility test and the leucocyte migration test were used as in vitro test systems for cell-mediated immunological reactivity. The results show a strong sensitivity against BP and uveoretinal and brain tissue homogenates in VKHS. In the patients suffering from chorioretinitis, a strong reactivity against uveoretinal homogenate only was found, while in patients with encephalitis, responses to brain antigens only were observed. Reactions towards spleen tissue homogenate were negative in all experiments. The extent to which this tissue-specific immunological reactivity, which is different from the monoreactivity in chorioretinitis or encephalitis, might be a characteristic phenomenon of the VKHS is discussed.

Eye Proteins↗
PubMed1979

[Unstable steroid-dependent hypotony-hypertony-syndrome (author's transl)].

The author reports an unusual case of a marked hypotony-syndrome without a recognizable cause, occurring after a previously operated chronic angle block glaucoma. On the assumption of a minimal cyclitis local corticosteroid therapy was commenced and lead to recovery of visual function. There were, however, problems in stabilizing intraocular tension both upwards and downwards. The steroids could not be withdrawn, even after 6 months, without the hypotony reappearing. On the other hand, the use of 2 drops of Decadron (dexamethasone) daily lead to tensions above 40 mmHg. The clinical situation is interpreted as a steroid-dependent hyposecretion-normosecretion in the presence of an occluded chamber angle.

Adrenal Cortex Hormones↗
PubMed1978

[Pyoderma vegetans of the eye-lid (author's transl)].

A cases of Pyoderma vegetans attacking only the outer skin of the eyelid and leaving free the conjunctiva is reported. The diagnosis of this rare condition, belonging to the pemphigus diseases, depends on clinical course and especially on histological investigation. The aetiology of Pyoderma vegetans still remains unknown, an immun-pathological mechanism is discussed.

Adult↗
PubMed1976

Demonstration of cell-mediated immunological reactivity to transplantation antigens in uveo-retinal tissues.

Lymph node cells from inbred rats, sensitized against allotransplantation antigens, were tested for reactivity against uveo-retinal tissues, using a two-step leucocyte migration inhibition test: (1) These tissues induced positive reactions indicating the presence of transplantation antigens. (2) This was true for strong and weaker histoincompatibility systems. (3) Quantitatively, uveo-retinal tissues were somewhat less reactive than lymphocytes as antigen.

Animals↗
PubMedDate not supplied

Histopathological comparison of photorefractive keratectomy and laser in situ keratomileusis in rabbits.

BACKGROUND: After 193 nm excimer laser photorefractive keratectomy (PRK) for myopia, superficial opacities in the ablation zone and regression of refractive results can occur. Clinical studies have emphasized that corneal clarity and early refractive stability can be achieved with laser in situ keratomileusis (LASIK). We present clinical and histological results that compare PRK and LASIK for the treatment of myopia in rabbits. MATERIALS AND METHODS: We treated 12 New Zealand white rabbits with PRK and 12 with LASIK using a 193-nm excimer laser (Aesculap Meditec). In both techniques, the identical excimer software and ablation parameters of -10 D treatment depth were used. Six months after surgery, all eyes were removed and prepared for light, fluoresence and transmission electron microscopy. RESULTS: At the time of enucleation, nine eyes in the PRK group had a moderate to high degree of haze (grade 2 to 3), whereas after LASIK, all corneas showed an almost clear interface in the ablation zone. Correspondingly, all histological investigations after LASIK showed a regular stromal architecture, in contrast to the obvious anteri or stromal disorganization after PRK. CONCLUSION: The preserved integrity of the superficial corneal layers after LASIK ensures quick wound healing with minimal tissue proliferation, resulting in a transparent corneal interface. This technique appears especially suitable for correcting high myopia.

Animals↗