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D V Cramer

Publications and source records attributed to D V Cramer.

At least 145 records · Page 8Linked to original sources
PubMed1980

Peptidase-3 (Pep-3), dipeptidase variant in the rat homologous to mouse pep-3 (Dip-1) and human PEP-c.

Starch gel electrophoresis and histochemical staining with L-leucyl-L-tyrosine have revealed genetic variation for dipeptidase in Rattus norvegicus. The tissue distribution, substrate specificity, and heterozygous expression as a monmeric protein suggest homology of the variant peptidase to human PEP-C and mouse Pep-3 (Dip-1). We propose Peptidase-3 (Pep-3) as a name for this autosomal locus in the rat. The allele responsible for slower (less anodal) electrophoretic migration is designated Pep-3a and is characteristic of strain ACI/Pit. A faster (more anodal) electrophoretic mobility is the product of the Pep-3b allele in strain F344/Pit. Twenty-five additional inbred strains carry Pep-3a and 16 others carry Pep-3b. Wild rats trapped in Pittsburgh were polymorphic for this locus. Alleles at Pep-3 segregated independently of c (linkage group I), a (linkage group IV), RT2 and Es-1 (linkage group V), h (linkage group VI), and RTI (linkage group VIII).

Animal Population Groups↗
PubMed1980

Cardiac allograft rejection and enhancement in natural recombinant rat strains.

Cardiac allografts were carried out using rat strain combinations with recombinant haplotypes. Rejection times were determined in unsensitized recipients, recipients that had been immunized to produce hyperacute or accelerated rejection, and recipients that had been i.v. immunized with 10(7) bone marrow cells to produce active enhancement. The graft survival results obtained suggest that there is a major influence of the A region or classical type I transplantation antigens in first set and hyperacute rejection whereas immunization to both A or B region (Ia) antigens may produce markedly prolonged survival. These data suggest major differential influences of major histocompatibility complex (MHC) subregions depending on the specific donor-recipient incompatibility as well as suggesting major influences in these three allograft models depending on the background of the strain used.

Animals↗
PubMed1978

The influence of maternal immunization on the antibody response of the offspring in genetically high-responding rats.

Immunization of high responding PVG female rats with poly(Glu52Lys33Tyr15) agrregated with methylated bovine serum albumin was associated with a decreased ability of their offspring to make an antibody response to the antigen. The amount of antigen given to the mothers was important in determining the magnitude of the antibody production in the offspring. The depression of antibody production was time-dependent: the first and second F1 litters from immunized mothers had significantly decreased antibody responses while no decrease was observed in the third F1 litter. Similarly, this alteration in the antibody response could be transmitted to the F2 generation but not to the F3 generation. These results suggest that aggregated antigen persists in the mother and crosses the placenta to interact with the developing immune system of the fetus. In the high-responding PVG strain, this interaction is associated with a decreased ability to respond to the antigen at a later time.

Animals↗