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Biomedical subjects

D V Gerasimov

Publications and source records attributed to D V Gerasimov.

8 recordsLinked to original sources
PubMed2001

[Mini-invasive methods of treatment of choledocholithiasis].

Last years in the clinic in diagnosis and treatment of choledocholithiasis choledochofibroscopy is applied widely while performing an open or laparoscopic intervention and while introduction of choledochoscope through external biliary fistula as well. Best results were achieved in those patients, in whom it was possible to evacuate all concrements through ductus cysticus. Introduction of biliary stent have permitted to perform clippage of ductus cysticus without making external drainage, securing rapid rehabilitation of patients.

Adolescent↗
PubMed1999

[Complications after laparoscopic cholecystectomy].

In 1780 patients the results of laparoscopic cholecystectomy (LCH) conduction for 1992-1997 period were analysed. In 1123 (63%) patients the operation was conducted for chronical and in 657 (37%)--for an acute cholecystitis. In 162 (9.1%) patients the choledocholithiasis features were revealed before the operation. In 46 (2.6%) patients the conversion to open laparotomy was accomplished. The LCH operation duration was from 35 to 190 min, (50 +/- 12) min in average. The frequency of an early complications occurrence was 8.8%, and in 18 (1.4%) patients the complications were revealed in late follow-up period. All the patients survived.

Adolescent↗
PubMed1996

[Laparoscopic cholecystectomy in acute cholecystitis].

Laparoscopic cholecystectomy was fulfilled in 108 patients admitted to the clinic with acute cholecystitis. Operations were made on 73% of them during the first four days from the beginning of the disease, 18.5% were operated upon within 5-7 days, 8.5% - 8 days later. Endoscopic papillotomy with removing the stones from the choledochus was performed in 10% of the patients before operation. Serious problems during taking the gallbladder from the inflammatory infiltration were observed in 29% of the patients. Technical problems took place more often if the patients were operated upon 5 days after the beginning of the disease. Change for open laparoscopy and standard cholecystectomy were necessary in 9 patients (8.3%). There were no lethal outcomes after laparoscopic cholecystectomy. Complications were observed in 12 patients (11.1%). The average period of staying at the hospital was (5.2 +/- 2.1) days. Laparoscopic cholecystectomy can be successfully performed in patients with acute cholecystitis by a sufficiently experienced surgeon.

Acute Disease↗
PubMed1995

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.

The suppressor of Hairy wing (su(Hw)) protein inhibits the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw)-binding sites. This polarity is due to the ability of the su(Hw)-binding region to form a chromatin insulator. Mutations in modifier of mdg4 (mod(mdg4)) enhance the effect of su(Hw) by inhibiting the function of enhancers located on both sides of the su(Hw)-binding region. This inhibition results in a variegated expression pattern, and mutations in mod(mdg4) act as classical enhancers of position-effect variegation. The mod(mdg4) and su(Hw) proteins interact with each other. The mod(mdg4) protein controls the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is transformed into unidirectional repression.

Alleles↗
PubMed1994

[The efficacy of different types of cholecystectomy for chronic cholecystitis].

The results of surgical treatment of 193 patients with chronic calculous cholecystitis were analyzed. In 89 of then the ordinary cholecystectomy (OC) was conducted, in 48--cholecystectomy through the minilaparotomy access (MC), in 56--laparoscopic cholecystectomy (LC). After OC conduction the incidence of postoperative complications was the greatest. After LC conduction the complications appeared in 5 patients, they started to stand up and walk on the second day, the majority of them were discharged from the hospital in 2 days. The hospital stay duration after LC conduction was (3.8 + 1.5) days on the average, while after MC and OC-(6.2 + 1.5) and (12.4 + 2.3) days accordingly. Essential advantage of LC over OC and MC was determined.

Adolescent↗
PubMed1990

[Therapeutic endoscopy in hemorrhages from varicose veins of the esophagus in patients with portal hypertension].

The article discusses 6-year experience in the treatment and prevention of esophageal hemorrhage by endoscopic sclerotherapy using 96% and 70% ethanol as the sclerosant. There were 99 patients under observation whose ages ranged from 27 to 70 years, 74 were admitted to the clinic with profuse hemorrhage. Sclerotherapy arrested the bleeding in 65 (90%) patients. Seven patients died from persisting bleeding, 5 from increasing hepatic insufficiency, and one patient from perforation of the esophagus and purulent mediastinitis. After discharge from the clinic 54 patients were kept under observation for periods of 6 to 20 months; 16 episodes of bleeding occurred in 13 of them. Repeated sclerotherapy proved effective in 10 patients, 3 patients died from continuing bleeding and hepatic insufficiency.

Adult↗