PubMed Health⌕ Search

Biomedical subjects

D V Horbelt

Publications and source records attributed to D V Horbelt.

26 records · Page 2Linked to original sources
PubMed1986

Dysgerminoma in the differential diagnosis of hydatidiform mole.

Serum measurements of beta-human chorionic gonadotropin (beta-hCG) for pregnancy tests are now positive at very low levels (25 mIU/mL). Sonography is the diagnostic method of choice for patients with the possibility of intrauterine trophoblastic disease. A case is reported in which ultrasound confused an ovarian neoplasm for a hydatidiform mole; a low level of hCG produced by the dysgerminoma corroborated the diagnosis. The tumor with syncytiotrophoblastic giant cells is described, and a differential diagnosis for minimally elevated hCG is discussed. This case represents an example of dysgerminoma presenting with ascites (stage IC).

Adolescent↗
PubMed1986

Nuclear and nucleolar areas: a quantitative assessment of endometrial neoplasia.

Quantitative methods were used to determine ultrastructural area differences in nuclei and nucleoli of normal proliferative endometrium as well as grades 1, 2, and 3 adenocarcinomas. Nuclear area distribution curves differed significantly among all groups. No significant differences were observed between nucleolar area distribution curves of normal proliferative and grade 1 adenocarcinomas. However, significant differences were found among distribution curves of all other groups. The computer-assisted high resolution ultrastructural examination provides a sensitive means of evaluating differences in nuclear and nucleolar areas of cells in normal and cancerous states.

Adenocarcinoma↗
PubMed1984

An ultrastructural comparison of grade I and II endometrial adenocarcinoma considering estrogen and progesterone receptor status.

Eighteen (18) previously untreated patients with grade I (9) and II (9) endometrial adenocarcinoma provided endometrial samples for biochemical analysis of estrogen and progesterone receptors. The same samples were evaluated by histology and ultrastructure. Progesterone receptor negative samples (PR less than 1000 fmole/g tissue) showed more ultrastructural characteristics of malignancy and a wider range of changes than the progesterone positive specimens (PR greater than 1000 fmole/g tissue). These findings appeared to be independent of estrogen receptor status. No significant ultrastructural changes were seen when grades I and II were compared.

Adenocarcinoma↗
PubMed1984

Scanning electron microscopy of the multifilament IUD string.

Fifteen multifilament strings on Dalkon Shield IUDs removed from patients were evaluated with scanning electron microscopy. All fifteen showed deterioration of the sheath which encloses the smaller inner filaments. The greatest area of deterioration was at the attachment knot which is usually intrauterine. Deterioration of the sheath also occurs when the device is within the uterine wall or intraperitoneal. The risk of pelvic infection may be attributed to this deterioration of the sheath and contamination from that site.

Bacterial Infections↗
PubMed1975

The ultrastructural response of human endometrium to medroxyprogesterone acetate.

Medroxyprogesterone acetate is a steroid compound similar to progesterone in structure and function. Thirty women were given 150 mg. of medroxyprogesterone intramuscularly, and samples of the endometrium were examined by light and electron microscopy. The initial response of normal human endometrium was maturation and then inhibition. By 50 days after injection, the atrophic changes began to reverse, and by Day 90, after injection the tissue resembled normal proliferative endometrium. A previously undescribed nuclear inclusion body is present; however, its significance is unclear at this time. On the basis of ultrastructural changes, medroxyprogesterone appeared not to exert a significant influence on the endometrium past 90 days at this dosage.

Adult↗