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D Válková

Publications and source records attributed to D Válková.

4 recordsLinked to original sources
PubMed2000

[Malignant mucosal melanoma of the head and neck].

Mucosal melanoma comparison to cutaneous melanoma of the head and neck are rare and do poorly. Approximately 0.5-2% of all melanomas occur from the mucous membranes of aerodigestive tract. Most common site of the tumor are the nasal cavity and paranasal sinuses but melanoma of the oral cavity are described too. Therapy usually consists of surgical resection with or without postoperative radiotherapy and immunochemotherapy eventually. The definite role of a kind of therapy in the treatment of mucosal melanoma is not remains to be defined as the small number of cases make prospective study challenging. This article reviews 19 patients with mucosal melanoma of the head and neck treated at the Department of ENT and Head and Neck Surgery Charles University of Prague since 1980 to 1999. Clinical data were obtained from the patient's charts. Analysis of the metastatic disease, type of therapy and follow-up was retrospectively reviewed. The site of the tumor was the lateral wall of the nasal cavity (five cases), nasal septum (four cases), maxilar cavity (two cases), and ethmoidal cavity, orbitoethmoidal complex, nasopharynx, saccus lacrimalis to ethmoidal sinuses diffused, tonsilla (one case each) and hypopharynx (two cases). Primary treatment was surgical resection in ten cases, in one case with radiation therapy, and in seven cases chemotherapy. In three cases were diagnostic surgery only and one patient was without therapy. Three patients received radical neck dissection more. Four patients were treated radiation therapy and three chemotherapy after surgery. In two cases were surgery after primary radiotherapy. For nine cases of recurrence of the disease were surgery (in five cases) and chemotherapy (in four cases). Overal and disease free interval was from 2 to 22 month, approximately 9.3 month and 3-year survival was 41.18%.

Adult↗
PubMed1981

Concentration of plasma middle molecular weight substances and clinical condition of patients undergoing short-time regular dialysis treatment.

Forty patients were dialysed 12 hours weekly for three years by 1 sq.m. Cuprophane coil dialyser. Clinical features, conventional laboratory data, concentration of middle molecular weight substances, and metabolic state were studied. No difference was found in the clinical picture during the short time dialysis schedule. Neither did the plasma concentration of middle molecular weight substances change substantially during this period. The metabolic state after three years of short time dialyses was good. The elimination of middle molecular weight substances by 1 sq.m. Cuprophane coil was sufficiently effective to prevent an excessive increase of their plasma level.

Creatinine↗
PubMed1978

[Short-term dialyses using a conventional hemodialyzer].

1. Twelve patients who were treated twice eight hours a week for at least one year were admitted to a dialysis plan of twice seven hours a week and fourteen patients who were dialysed twice eight hours a week for at least one year were dialysed thrice four hours a week. The patients were dialysed with a spool dialysator with cuprophan membrane of a surface of 1 m2. Blood flow was 200--250 ml/min., dialysate flow 500 ml/min. After 3, 6, 10, and 12 months the clinical picture, hydratation, protein katabolism, degree of anaemia and renal osteodystrophy as well as number of complications, degree of rehabilitation, concentration of the medium-molecular substances and of phenylalanine and the glucose tolerance were compared and the opinion of the patients concerning different types of the plan of dialysis was inquired. 2. The plan of dialysis of thrice four hours a week with a conventional dialysator is sufficient for a good state of the most patients. In none of the parameters investigated by us we could establish noticeable differences between the dialysis plan twice eight hours and twice seven hours and thrice four hours a week. The patients themselves clearly preferred a plan of dialysis of thrice four hours a week. 3. The concentration of medium-molecular substances in the blood is no sufficiently sensitive indicator for the determination of the quality of a permanent dialysis treatment in a good clinical state of the patient.

Adult↗