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Biomedical subjects

D Van den Berge

Publications and source records attributed to D Van den Berge.

4 recordsLinked to original sources

Using appropriate comparisons in economic evaluations. An exercise in Belgium.

This paper considers standard effective treatments for non-Hodgkin's lymphoma and early breast cancer in premenopausal women. The literature assesses the treatments' effectiveness, and expected charges for different treatments in the context of the Belgian Health Insurance System are compared. Ovariectomy in breast cancer (770 ECU) and conventional chemotherapy in non-Hodgkin (2,745 lymphoma ECU) prove equally effective and are less costly in comparison with chemotherapy (1,904 ECU) in breast cancer or chemotherapy and autologous bone marrow transplantation (19,262 ECU) in non-Hodgkin's lymphoma. Further unbiased insights in competitive treatments' costs and outcome could save money and enhance developments in cancer care.

Belgium↗

Microprocessor controlled limitation system for a stand-alone freely movable treatment couch.

Because of the capability of free movement in the treatment room, we recently introduced a Hercules treatment couch on one of our linear accelerators. One of the advantages of this couch is that it allows for a more flexible way of patient setup and that it can be moved entirely out of the way to enable treatment with a hospital bed. A disadvantage, however, is that the couch can hit a wall or a cover of the accelerator accidentally. A limitation system has been developed to protect both the table and the accelerator against such collisions.

Algorithms↗

Computers create new perspectives in radiotherapy.

In diagnostic radiology a revolution has taken place over the last decade with the development of computer-based imaging (CT, MR). Such technologies are now available routinely even in medium-sized radiology departments. In radiotherapy departments, however, computer applications have often been limited to calculation of dose distributions on CT images and administrative tasks. The last few years applications are emerging and utilize the full power of modern computer technology and promise to revolutionize treatment planning and execution in everyday radiotherapy. The authors present their view on some of these applications and the way they may push ahead frontiers in clinical radiotherapy.

Humans↗

5'-Nor-anhydrovinblastine (Navelbine) has an anti-invasive effect on MO4 mouse fibrosarcoma cells in vitro and in vivo.

5'-nor-anhydrovinblastine (Navelbine) is a hemisynthetic Vinca alkaloid for which a selectivity for mitotic microtubules has been demonstrated. In previous studies, we have demonstrated an anti-invasive effect of other Vinca alkaloids. Here the results of in vitro and in vivo assays concerning the effect of 5'-nor-anhydrovinblastine on growth and invasion of MO4 cells are presented. It is demonstrated that at cytostatic concentrations, 5'-nor-anhydrovinblastine also has an anti-invasive effect.

Animals↗