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Biomedical subjects

D Vidt

Publications and source records attributed to D Vidt.

6 recordsLinked to original sources

Renal transplantation of patients on chronic peritoneal dialysis.

A retrospective review of patients transplanted from peritoneal dialysis was performed to assess the risk of this form of dialysis for patients awaiting renal transplantation. Eighteen transplants have been performed in 16 patients, ages 6 to 57 years, undergoing chronic peritoneal dialysis over the past 4 years. Sixteen were from cadaver donors, and two were from living related donors (LRD). The patients had been undergoing intermittent peritoneal dialysis or continuous ambulatory peritoneal dialysis (CAPD) using permanent silastic catheters, from five days to 4 years. No patient had clinical evidence for peritonitis at the time of transplantation. The peritoneal catheter was removed at the time of transplant in all cadaver donor recipients without complication. One recipient of a LRD kidney had the catheter removed two days prior to transplant. Cultures of the catheter were sterile in 16 cases. Two patients had positive peritoneal catheter cultures at the time of transplant but were treated with appropriate antibiotics and never developed clinical peritonitis. Fourteen transplants had postoperative fevers. No definite source was found in 13; one had fever in relation to acute graft rejection. The fevers resolved in all patients either spontaneously or subsequent to therapy. Other complications were similar to those seen in patients transplanted from hemodialysis. Hemodialysis was performed as needed pretransplant and posttransplant using a temporary femoral vein catheter or arteriovenous fistula without complication. Nine patients are alive with a functioning kidney 1 to 36 months posttransplant (mean 17 months). Six transplants rejected (five patients), and one failed secondary to renal vein thrombosis. Two patients died posttransplant, one after a cerebrovascular accident, and one due to an unknown cause 1 month postnephrectomy for rejection. In conclusion, patients undergoing chronic peritoneal dialysis can be successfully transplanted without a significant incidence of complications related to their peritoneal dialysis.

Adolescent↗

The use of percutaneous transluminal angioplasty for renal artery stenosis in patients with generalized atherosclerosis.

From April 1979 to March 1981 percutaneous transluminal angioplasty was attempted in 27 patients with atherosclerotic renal artery stenosis. In 13 patients percutaneous transluminal angioplasty was considered successful with a decrease in blood pressure and/or improvement in renal function. Dilation of the stenosed renal artery was not technically possible in 4 patients and was unsuccessful in 10. Eight patients required surgical intervention after percutaneous transluminal angioplasty, including 4 electric operations and 4 done on an emergency basis. In our series 5 patients sustained intimal tears of the renal artery during percutaneous transluminal angioplasty with intramural dissection and/or thrombosis. Continued multidisciplinary evaluation of percutaneous transluminal angioplasty in the treatment of renal artery stenosis is recommended.

Adult↗

Diminished operative morbidity and mortality in renal revascularization.

From 1974 to 1980, one hundred consecutive patients with atherosclerotic renovascular disease underwent revascularization. There were two operative deaths and eight postoperative complications. This low operative morbidity is attributed to preoperative screening, correction of existing coronary or cerebrovascular disease, and reliance on methods of revascularization that obviate operation on a badly diseased aorta. The results in 78 patients with renovascular hypertension were 40% cured, 51% improved, and 9% failed. In 22 patients in whom revascularization was performed to preserve renal function, the postoperative serum creatinine levels were improved in 19 patients, remained stable in two patients, and increased in one patient.

Adult↗

The coiled envelope-a disposable insert for coil dialysis.

The coiled envelope, a disposable pre-sterilized insert for coil dialysis, and its associated hardware were developed. In vitro and in vivo characterizations of the dialyzer were carried out and clinical dialyses performed. Clinical studies show the efficacy of the device and indicate advantages in its design. The dialyzer can be assembled in less than 5 minutes. The blood fluid path materials are replaceable in the coiled envelope kidney and can be certified sterile and pyrogen-free for each dialysis. This is a distinct advantage over the reuse of commercial dialyzers which can not be certified after their initial use. The disposable insert could be made available for patient use at a cost about one-half that of present commercial dialyzers.

Animals↗