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Biomedical subjects

D Vittecoq

Publications and source records attributed to D Vittecoq.

At least 91 records · Page 5Linked to original sources
PubMed1985

Penetration of imipenem and cilastatin into cerebrospinal fluid of patients with bacterial meningitis.

The penetration of imipenem and cilastatin into the cerebrospinal fluid (CSF) was determined in patients with bacterial meningitis. Four 1000 mg doses [corrected] of both imipenem and cilastatin were infused intravenously over 20-30 min at 6 h intervals, first between days 2 and 4, and again, whenever possible, between days 11 to 20, in 12 patients with bacterial meningitis undergoing treatment with other antibiotics. Concentrations of imipenem and cilastatin in serum and cerebrospinal fluid samples obtained either at 60, 90 or 120 min following the fourth dose were measured by high pressure liquid chromatography. Concentrations of imipenem in CSF ranged from 0.5 to 11 mg/1 and concentrations of cilastatin ranged from 1.1 to 10.5 mg/1, depending on the sampling time and the time elapsed since the onset of the disease.

Adult↗
PubMed1983

Neutropenia due to beta lactamine antibodies.

Neutropenia developed in 13 patients during treatment with beta lactamines. The time of onset ranged from eight to 27 days after beginning treatment and occurred with doses as low as 40 mg/24 hours. Concomitant symptoms were eosinophilia, rashes, and fever. Leucoagglutinins were detected in eight out of nine patients by the microleucoagglutination technique. Clinical and serological findings suggested that neutrophils become sensitised as a result of absorption on the cell membrane of drug-antibody immune complexes. An immune mediated pathogenesis for neutropenia induced by beta lactamine seems highly probable.

Adult↗
PubMed1983

AIDS in a black Malian.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1983

[Anti-smooth-muscle antibody activity of monoclonal IgM in Waldenström's disease].

The authors report a case of Waldenstrom disease in which the IgM kappa immunoglobulin had an anti-smooth-muscle activity at a very high titre (1/100 000). This activity was found in the purified IgM but not in the Fab fragment; nevertheless, the immunofluorescence inhibition by this fragment is evidence in support of the anti-smooth-muscle activity of the IgM. The IgM specificity in this patient is different from the anti-smooth-muscle antibodies already described.

Antibodies, Monoclonal↗
PubMed1983

[Treatment of 18 cases of purulent meningitis with moxalactam. Pharmacokinetic data].

The diffusion of moxalactam into cerebrospinal fluid was studied in 18 hospital patients with purulent meningitis treated with this antibiotic. Moxalactam was administered by intravenous infusion in doses of 2 g 8-hourly (6 g/24 h). Treatment lasted from 10 to 30 days depending on the pathogen involved. The antibiotic was assayed by high performance liquid chromatography simultaneously in serum and CSF at the time of lumbar puncture. Depending on the time elapsed since the end of the infusion, the mean CSF concentrations ranged from 32.8 to 9.37 micrograms/ml at the beginning of the disease and from 23.75 to 3.78 micrograms/ml toward the end of treatment. These values were notably higher than the MIC for most of the micro-organisms encountered. All patients were cured.

Adult↗
PubMed1983

Penetration of ceftazidime into cerebrospinal fluid of patients with bacterial meningitis.

Four 2-g doses of ceftazidime were infused intravenously over 30 min at 8-h intervals, first between days 2 and 4 and again between days 11 and 20, in 11 patients with bacterial meningitis undergoing treatment with other antibiotics. Concentrations of ceftazidime in serum and cerebrospinal fluid samples obtained 120 or 180 min after dose 4 were measured by high-pressure liquid chromatography. Concentrations in cerebrospinal fluid ranged from 2 to 30 micrograms/ml, depending on the sampling time and the time elapsed since the onset of the disease.

Adolescent↗