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Biomedical subjects

D Vranjesević

Publications and source records attributed to D Vranjesević.

At least 19 recordsLinked to original sources
PubMed1999

Serum tryptophan to large neutral amino acid ratio and urinary tryptophan in three patients with phenylketonuria in a family. A clinical and biochemical study.

In this work clinical and biochemical findings are presented in three untreated children with phenylketonuria in a family. Their clinical pictures were not typical for classical phenylketonuria. As a result, diagnosis was missed. It has been shown that patterns of large neutral amino acids in serum and urine were somewhat different. Significantly lower serum TRP/LNAA ratio was observed in all patients with phenylketonuria, compared to the control group. These findings suggest that there was subnormal tryptophan availability in the central nervous system leading to its decreased metabolism through the serotonin and kynurenine pathways. These results may explain decreased children's growth and their mental deficiency.

Adult↗
PubMed1993

[Clinical manifestations of Lyme disease in pediatric neurology].

The most important characteristics of Lyme disease in childhood age are presented. Difficulties in diagnostics and the most important possibilities in differential diagnosis are stressed. It is believed that some cases of lyme disease remain unrecognized as the result of poor knowledge about the disease--a not unexpected fact considering that lyme disease is described only in the newest editions of pediatric neurology.

Child↗
PubMed1991

[The (18)(q 22----qter) deletion in patients with complete clinical features of the De Grouchy syndrome].

A case of a 4-year old boy with de Grouchy syndrome was reported. The patient showed generalised muscular hypotonia, marked mental retardation (RQ = 30), developmental milestones retarded, craniofacial dysmorphic features, congenital heart disease, abnormalities of the external genitalia and skeletal deformities. The karyotype analysis revealed a partial deletion of the distal bands of chromosome 18:48 48 xy del (18) (q 22----qter). Qualitative and quantitative characteristics analysis of digital and palmar dermatoglyphics supported the diagnosis.

Child, Preschool↗
PubMed1989

[Reading disorders in children with partial epilepsy].

This study represents a neuropsychological evaluation of reading ability in children with partial epilepsy (PE), aged 7-14 years, of normal intelligence, without neurological deficits and physical handicaps, appropriate environment stimulation and learning opportunities. A control group consisted of 202 healthy school children. Reading disabilities were significantly more frequent in children with partial epilepsy, especially in patients with PE with complex symptomatology. The children from the control group had better results of the tests of both verbal and performance intelligence, but children with reading disabilities had greater performance IQ than verbal IQ. Significant intergroup difference was related to the children aged 7-10 years. Positive evidence of left dominant hemisphere superiority for reading has been shown. Dyslexia was significantly more frequent in patients with left hemisphere epileptic foci, than in those with right hemisphere focal EEG changes.

Adolescent↗
PubMed1989

Motor coordination maturity in healthy 7-10 years old children.

Finger-nose test and the test of diadochokinesis were performed in order to estimate motor coordination maturity in healthy children aged 7-10 years. Occurrence of immature motor coordination was recorded significantly more often in sever-year-old children (present in 44%) than in the other age groups (present in 20-27%). In some children it was present only on the side of nondominant hand, and in the rest of them bilaterally. Positive correlation between the level of ability to perform the applied tasks and specific relations between different types of lateralization are discussed.

Child↗
PubMed1989

Lesch-Nyhan syndrome: the differential diagnosis and actual aspects.

The paper presents a case of a nine-year-old boy with Lesch-Nyhan syndrome whose disease was characterized by: a) clinical presentation (psychomotor retardation, involuntary movements, self-mutilatory behavior) b) biochemical features (increased levels of uric acid in serum and urine, index uric acid/creatinine) c) typical diagnostic ommision that lasted up to the terminal stage of the disease In order to provide the possibility of better diagnosis (which includes possibilities of genetic consulting, antenatal diagnosis and treatment of the disorder which is extremely unpleasant both to the patient and to his family) the most common diagnostic errors are discussed. Since the biochemical deficit is the only one which produces the occurrence of Lesch-Nyhan syndrome, the disease is commonly used as a model for investigations of the biochemical basis of human behavior.

Child↗
PubMed1989

SSPE-epidemiology and measles vaccination: our cases.

We are discussing the results of an epidemiologic prospective study of 194 children with SSPE. We analyzed, registered and treated these SSPE patients in the period from 1952 to 1983 at the Department for Child Neurology and Psychiatry in Belgrade. There were 140 boys and 54 girls with SSPE. The male to female ratio was 2.6:1. The average age of onset was 8.3 years for boys and 7.2 years for girls, the overall average being 7.7 years. The average duration of illness was 10 months for boys and 8 months for girls; the overall average duration of SSPE was 9 months. The average age for measles infection was 2.4 years. The interval between measles infection and clinical manifestation of SSPE was 5.5 years. The patients came from different parts of Yugoslavia. Most of them were from SR Serbia (95 patients or 49%), AP Vojvodina (39 patients or 20%), SR Bosnia and Herzegovina (22 patients or 11%), AP Kosovo (14 patients or 7.2%), SR Macedonia (14 patients or 7.2%), SR Croatia (6 patients or 3%), and SR Montenegro (4 patients or 2.5%). Mass measles vaccination started in SR Serbia in 1972. In the period 1952-1983 there was an average of six registered patients with SSPE per year. In the same period, there were four peaks of illness: 20 patients in 1957, 15 patients in 1958, 12 patients in 1961, and 9 patients in 1977. The average number of SSPE per year in the period 1952-1972 was 7.2 patients before mass vaccination. The average number of SSPE per year in the period 1973-1983 was 3.3 patients after mass vaccination.

Adolescent↗
PubMed1986

Poland syndrome associated with 'morning glory' syndrome (coloboma of the optic disc).

A 12 year old girl with the Poland syndrome and the 'morning glory' syndrome is described. The patient presented with absence of the left pectoralis major muscle, hypoplasia of the left arm, symbrachydactyly, and ipsilateral coloboma of the optic disc. This is the first report of the association of these two congenital anomalies.

Abnormalities, Multiple↗