PubMed Health⌕ Search

Biomedical subjects

D W Aaronson

Publications and source records attributed to D W Aaronson.

13 recordsLinked to original sources
PubMed1997

Dose ranging study of mometasone furoate (Nasonex) in seasonal allergic rhinitis.

BACKGROUND: Topical nasal corticosteroids are rapidly gaining acceptance as first-line therapy for seasonal allergic rhinitis, but there is a desire for effective corticosteroids with an improved safety profile over existing products. OBJECTIVE: A multicenter, double-blind dose ranging study was conducted to compare the activity and tolerance of four doses of mometasone furoate nasal spray (tradename Nasonex) and placebo in adult patients with seasonal allergic rhinitis. METHODS: Four hundred eighty patients with seasonal allergic rhinitis were enrolled and randomized to receive mometasone furoate nasal spray 50 micrograms (n = 96), 100 micrograms (n = 95), 200 micrograms (n = 98) or 800 micrograms (n = 95), or placebo vehicle (n = 95) once daily for 28 days. RESULTS: All of the doses of mometasone furoate nasal spray showed activity in reducing the severity of rhinitis. The 200-microgram dose reduced total nasal symptom scores and total symptom scores throughout the study (P < .05 versus placebo vehicle). The 50-microgram dose and the 100-microgram dose showed less consistent activity at early timepoints (days 3 and 7), while the 800 microgram dose did not provide significant additional benefits over the 200-microgram dose. All dose levels were well tolerated CONCLUSION: The results of this trial indicate that 200 micrograms once daily is the optimum dose of mometasone furoate nasal spray for the treatment of seasonal allergic rhinitis.

Administration, Intranasal↗
PubMed1996

Evaluation of cetirizine in patients with allergic rhinitis and perennial asthma.

BACKGROUND: Cetirizine, a highly specific H1 receptor antagonist with modest sedation and anticholinergic effects at the higher doses required for bronchodilation, may be useful for treating concomitant allergy and symptoms of asthma. OBJECTIVE: This study evaluated the effectiveness of cetirizine compared with placebo in patients with allergic rhinitis and concomitant symptomatic mild to moderate perennial asthma. METHODS: Twenty-eight patients (13 females and 15 males) aged 13 to 59 years having allergic rhinitis and mild to moderate perennial asthma were treated for 26 weeks with 20 mg cetirizine or placebo. Daily diary entries of symptoms, medications taken and peak expiratory flow rate measurements (morning and evening), biweekly pulmonary function tests, and monthly global evaluations by investigators were performed. RESULTS: Cetirizine treatment significantly reduced baseline severity of several symptoms of rhinitis (itchy nose, nasal congestion, and watery eyes), and asthma (chest tightness, wheezing, shortness of breath, and nocturnal asthma). Although not statistically significant, cetirizine also reduced other symptoms of rhinitis (sneezing, itchy eyes, postnasal drip, and runny nose) and asthma (cough and sputum production), reduced albuterol use, and increased mean peak expiratory flow rates compared with placebo. No differences between treatment groups were noted for patient satisfaction, patient and physician global assessments of asthma management, pulmonary function, and methacholine challenge tests. Of two cetirizine patients with adverse events, one event, moderate drowsiness, was considered to be related to study drug. CONCLUSIONS: Cetirizine reduced symptoms of rhinitis as well as symptoms of asthma in patients with allergic rhinitis and concomitant perennial asthma.

Adolescent↗
PubMed1993

Effects of terfenadine on psychomotor performance. An overview.

Sedation and impairment of psychomotor performance are well known adverse effects of the traditional antihistamines. These effects appear to be caused by different mechanisms, but both may have potentially dangerous consequences. while several of the newer antihistamines, such as terfenadine, have overcome the problem of sedation, it is also important to establish their propensity to cause psychomotor impairment. Many single- and multiple-dose studies (mostly in healthy volunteers) have compared the effects of terfenadine on psychomotor performance with those of placebo, as well as traditional and other nonsedating antihistamines. Over half of the studies employed divided-attention tasks that are considered relevant to everyday activities, such as driving. Like several other nonsedating antihistamines, single doses of terfenadine of up to 120 mg did not impair driving performance and generally had no significant effects on other psychomotor tests compared with placebo. In most of the multiple-dose studies, terfenadine 60 mg twice daily was administered for up to 5 days. Again, the effects of terfenadine on psychomotor performance differed little from those of placebo. Thus, the available evidence suggests that the problem of impaired psychomotor performance associated with the older, traditional antihistamines does not apply to terfenadine.

Clinical Trials as Topic↗
PubMed1991

Comparative efficacy of H1 antihistamines.

Second-generation H1 receptor antagonists (cetirizine, terfenadine, astemizole, loratadine, azelastine, and acrivastine) offer several important advantages over the older first-generation antihistamines. They are substantially less sedating and have little or no anticholinergic activity. Many of them are effective for 12 to 24 hours, thereby increasing compliance. In addition to acting as competitive inhibitors of histamine, several seem to have other antiallergic mechanisms as well. They are all absorbed well when taken orally. Many studies demonstrate their effectiveness compared with placebo in the treatment of seasonal and perennial rhinitis and chronic urticaria, and several studies suggest that they have a role in the treatment of bronchial asthma. A number of multicenter, double-blind, placebo-controlled studies comparing the effectiveness of terfenadine, 60 mg bid, with chlorpheniramine, 8 mg bid, in seasonal allergic rhinitis demonstrate that both drugs are approximately equally potent in reducing the symptoms of sneezing, rhinorrhea, and nasal itching and are statistically significantly better than placebo. Ocular symptoms were reduced somewhat less but still significantly. No differences from placebo were recorded in their effect on nasal congestion. The effectiveness of cetirizine, 10 mg once daily, compared with astemizole, 10 mg once daily, was measured in double-blind, placebo-controlled studies of patients with seasonal allergic rhinitis. These studies also demonstrate statistically significant benefit from the study drugs compared with placebo in relieving all nasal symptoms except congestion. Both drugs also relieved ocular pruritus. Fewer studies have assessed azelastine, acrivastine, and loratadine, but all have been shown to provide significant relief of seasonal allergic rhinitis compared with placebo.(ABSTRACT TRUNCATED AT 250 WORDS)

Histamine H1 Antagonists↗
PubMed1977

Allergic bronchopulmonary aspergillosis in three patients with normal chest x-ray films.

Three patients with allergic bronchopulmonary aspergillosis had normal chest x-ray films at the time of dianosis. None had a history of pneumonitis or abnormal chest x-ray films in the past. On the basis of clinical and immunologic data that indicated the presence of allergic bronchopulmonary aspergillosis, bronchograms were obtained, which revealed evidence of proximal bronchiectasis in each patient. These early changes in bronchial architecture were not evident on the plain x-ray films of the chest but were revealed by bronchographic study. The diagnosis of allergic bronchopulmonary aspergillosis may be made even in the presence of normal chest x-ray films.

Antibodies, Fungal↗