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Biomedical subjects

D W Angarano

Publications and source records attributed to D W Angarano.

10 recordsLinked to original sources

Paraneoplastic bullous stomatitis in a horse.

An adult horse with a 2-month history of anorexia, ataxia, and oral blisters had developed these clinical signs just prior to the appearance and growth of a cervical mass. Bullous stomatitis was characterized histologically as subepidermal clefting. Clinical signs were unresponsive to treatment with antibiotics or corticosteroids; however, surgical removal of the mass coincided with remission of all signs. Histologic findings of the mass were consistent with hemangiosarcoma. Results of indirect immunofluorescence and immunoprecipitation on frozen serum from the horse were characteristic of paraneoplastic pemphigus in human beings, a newly recognized mucocutaneous autoimmune disease associated with neoplasia.

Animals↗

Erosive and ulcerative skin disease.

Many causes exist for ulcerative disease of the skin and mucous membranes of cats. History, physical examination, cytology, skin biopsy, a hemogram, serum biochemical evaluation, and FeLV and feline immunodeficiency virus testing are a standard diagnostic protocol for such cases. Therapy is dependent on the underlying cause. Symptomatic therapy consisting of cleansing soaks (chlorhexidine) and systemic antibiotics (trimethoprim-sulfadiazine or amoxicillin-clavulanic acid) may be helpful to control secondary bacterial infections. If ulceration is widespread, serum leakage may result in a decreased total protein and more systemic signs. When oral ulcers are present, food and water consumption may be affected. Enteral nutrition may be helpful to sustain the cat during the diagnostic workup or until results of treatment are evident.

Animals↗

Adrenocorticotropic hormone and cortisol concentrations after corticotropin-releasing hormone stimulation testing in cats administered methylprednisolone.

The hypothalamic-pituitary-adrenocortical (HPA) axis was studied in 8 healthy cats after administration of supraphysiologic doses of methylprednisolone (MP). Ovine corticotropin-releasing hormone (oCRH) administration increased cortisol and adrenocorticotropic hormone (ACTH) concentrations. Significant (P < 0.05) suppression of cortisol and a trend toward suppression of ACTH was observed after 1 week of MP administration. The HPA axis quickly recovered from suppressive effects of MP 1 week after administration of the steroid was discontinued. Side effects of oCRH administration were minimal in 7 cats; however, 1 cat had a severe hypotensive reaction. Clinical abnormalities were not associated with MP administration. The HPA axis was suppressed by supraphysiologic doses of MP in all treated cats that lacked clinical signs consistent with iatrogenic HPA axis suppression. Despite the relatively active pars intermedia in cats, compared with human beings and dogs, feedback of MP on the HPA axis resulted in similar trends in oCRH-stimulated ACTH and cortisol concentrations as observed in human beings and dogs. Lack of consistent correlation between ACTH and cortisol concentrations was observed in 3 cats and possibly was related to the active pars intermedia in the cat.

Adrenocorticotropic Hormone↗

Biopsies of the skin and mucous membranes.

A skin or mucous membrane biopsy is an important diagnostic technique in veterinary dermatology. Careful thought must be given in the selection of which animal patients to biopsy and what lesions to biopsy. Care must be taken in performing the biopsy to avoid traumatic artifacts that make interpretation difficult for the pathologist. Finally, histological findings are just one assessment and must be coupled with a thorough history, physical examination, and other laboratory findings before a definitive diagnosis is offered.

Animals↗

Efficacy of cefadroxil in the treatment of bacterial dermatitis in dogs.

Cefadroxil was found to be an effective antibiotic for the treatment of canine bacterial pyoderma. Bacterial pyoderma was diagnosed in 30 dogs, which were treated with cefadroxil administered orally at 22 mg/kg of body weight, q 12 h, for 21 to 30 days. Dogs were reexamined at the conclusion of antibiotic treatment, and 29 were found to have good to excellent response. On the basis of this study, cefadroxil is a good choice in the treatment of canine pyoderma when cephalosporins are necessary. Efficacy, frequency of administration, cost, and veterinary approval are the major advantages.

Animals↗

Diseases of the pinna.

Many diseases can affect the pinna of the dog and cat. These diseases represent most categories of cutaneous disease, from infectious to neoplastic. Although some diseases affect primarily the pinna, most pinnal dermatoses occur in conjunction with other integumentary disorders. One should approach the diagnostic work-up of pinnal disease in an organized manner, obtaining first a thorough history and physical examination. A systematic approach is required in the diagnostic evaluation in order to arrive at a tentative or definitive diagnosis. Skin scrapings, cytologic examination, and culture for dermatophytes provide the minimum database. A variety of diagnostic tests, including hematology, serum biochemical profiles, urinalysis, serology, intradermal skin testing, hypoallergenic diet trials, histopathology, and direct immunofluorescence, may be necessary in some cases before a definitive diagnosis is reached. The ears are somewhat difficult to biopsy, although in many instances histopathologic examination is essential to the diagnosis. In this author's opinion, it is preferable to use a no. 15 scalpel blade rather than a punch biopsy when obtaining a pinnal biopsy. This allows the veterinarian to obtain an elliptical or wedge biopsy, which can frequently be sutured. In some instances, biopsies are required from the ear margin and a full ear thickness biopsy is obtained. Sutures may not hold in this situation, and cautery may be necessary for hemostasis. As in other situations in which the ear is bleeding (aural hematomas, vasculitis, fly bite dermatitis, and so on), bandaging and immobilization of the ear may be necessary to prevent further trauma. Although symptomatic therapy is sometimes helpful when treating pinnal diseases, a definitive diagnosis is preferred. This is especially important following the second or third presentation of an animal for ear disease. Although ear diseases are frequently viewed as a nuisance rather than a serious condition, anyone who has owned or worked closely with an animal suffering from chronic otitis externa should appreciate the animal's discomfort and the owner's frustration. All too frequently, the chronic otitis externa is the result of a hypersensitivity (either inhalant or food) that has been overlooked in the attempt to treat the subsequent infectious otitis. Thus, in animals with recurrent otitis externa, every attempt should be made to identify and treat the underlying etiology.

Animals↗

Use of ketoconazole in treatment of dermatophytosis in a dog.

Ketoconazole, an antifungal imidazole derivative, was used successfully to treat Tricophyton mentagrophytes infection in a dog. The drug was administered orally (11 mg/kg of body weight, q 24 h) and continued for 90 days. Though ketoconazole is not licensed currently for veterinary purposes, it has been used successfully to treat dermatophyte infections as well as intermediate and deep fungal diseases in both dogs and cats. In this case, ketoconazole was found to be nontoxic and less expensive than griseofulvin in the treatment of dermatophytosis.

Animals↗

Chronic problem wounds of dog limbs.

Other dermatoses are capable of affecting the limbs and paws of dogs. One should approach the diagnostic workup of these cases in an organized manner, first obtaining a thorough history and performing a physical examination. A variety of diagnostic tests, including skin scrapings, cytology, fungal cultures, bacterial cultures, hematology, serum biochemical profiles, urinalysis, serology, radiology, histopathology, and direct immunofluorescence testing, may be necessary before a definitive diagnosis is reached. Therapy may be surgical, medical, or a combination of both depending upon the etiologic agent.

Animals↗