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Biomedical subjects

D W Furnas

Publications and source records attributed to D W Furnas.

At least 55 records · Page 3Linked to original sources
PubMed1982

Efforts to enhance survival of limb allografts by prior administration of whole blood in rats using a new survival end-point.

Injecting whole blood into the recipient before surgery can significantly prolong renal transplant survival in rats. Therefore, experiments were performed in rats to study the effects of prior administration of whole blood on the survival of limb allografts. Tests to quantitate survival of the allografts included monitoring the internal temperature of the leg, assaying serum creatine kinase levels, and testing for alloantibodies. Lewis recipients of (BN x LEW)F1 limb transplants that received 1 ml of BN or (BN x LEW)F1 whole blood before surgery had mean survival times that were longer compared with controls as measured by a 10 F change in temperature. In a test-retest experiment, decline of temperature proved to be a reliable quantitative determination of limb allograft survival since a difference of only 5.6% was observed in the mean number of days of graft survival between two separate groups of control Lewis recipients. Moreover, combined data demonstrated that control Lewis recipients of (BN x LEW)F1 limb allografts averaged 24.0 days of graft survival based on a 10 F decline in temperature with a 95% confidence interval of +/- 6.3 days. It is concluded that prior administration of whole blood can produce significant prolongation of survival in organ transplantation, but it is not as effective in enhancing survival of limb allografts. It is also concluded that internal temperature measurement of limb allografts is an easy, effective, and quantitative method of monitoring rejection.

Animals↗
PubMed1982

Subcutaneous mastectomy for juvenile hypertrophy of the breast: report of a case.

Massive juvenile hypertrophy of the breast in a 12-year-old girl was successfully treated with a primary subcutaneous mastectomy and secondary placement of gel-filled silastic implants. The patient weighed 114 pounds and her breasts weighed 15 1/2 pounds. Small foci of regrowth occurred at the lateral ends of the mastectomy incisions only; a total of five of these foci were removed. Six years later no evidence of further residual breast tissue was noted and the breasts have been satisfactorily reconstructed.

Breast↗
PubMed1981

Two cases of orbital dystopia: Tessier III cleft and craniofacial osteomas.

Two cases of orbital dystopia are reported. One was caused by a Tessier III cleft and was treated by cranio-facial osteotomies of three walls of the orbit, allowing the left to be moved upward. The second involved multiple craniofacial osteomas and was treated by extractional osteotomies of four walls of the orbit including a transverse split of the roof. These osteotomies were entirely extramucosal.

Adolescent↗
PubMed1981

Craniofacial duplication (diprosopus).

No congenital malformation in infants is more profound than anterior craniofacial duplication. The precise term for this rare anomaly is diprosopus, referring to a fetus with a single trunk, normal limbs, and varying degrees of facial duplication. A search of the world literature produced only 16 cases of diprosopus since 1864. Despite the rarity of this anomaly, three such infants were born in the Southern California area during the past year, making this the largest reported series to date. The three infants were born with two distinctly formed faces. Each had four separate eyes, two mouths, two noses, and two ears with a primitive ear or sinus tract at the plane of fusion. In addition, multiple congenital aberrations existed which involved a variety of internal organs. The pathogenesis of diprosopus is not well understood, but environmental stress early in embryologic development has been suggested as a possible factor. The apparent mechanism is a slowing of pregastrulation oxidation with resultant focal developmental arrests.

Abnormalities, Severe Teratoid↗
PubMed1980

Microvascular reconstruction of the mandible.

Five microvascular reconstructions of the mandible were performed in the past 2 years. One dorsalis pedis osteocutaneous flap was used to reconstruct the alveolar ridge and four groin osteocutaneous flaps were used for various defects of the mandible. Free microvascular bone grafts were found useful in previously irradiated fields, in anterior arch reconstruction, and in patients with massive soft tissue and bone loss.

Adult↗
PubMed1980

The myocutaneous flap: a versatile approach to major reconstructive problems.

Our experience with 50 myocutaneous flaps shows that the remarkable flexibility in design and execution of these flaps has opened up a new frontier in plastic and reconstructive surgery. The complication rate was 20 percent. Only one complication, partial flap necrosis, caused serious compromise of the reconstruction. Not only could the flaps be transposed in any direction locally, but they could be transferred to distant sites with microvascular anastomoses, and muscle function could be restored by incorporating nerve repairs into the reconstruction. Myocutaneous flaps permit us now to solve reconstructive problems that were heretofore unsolvable.

Adult↗
PubMed1980

The pulley canthopexy for residual telecanthus after hypertelorism repair or facial trauma.

The onset of canthal drift after hypertelorism repair can nullify the effectiveness of the repair, despite roentgenographic evidence of normal interorbital distance. The problem of hypertelorism is simply replaced by the problem of telecanthus. An excess of bulky tissue between the orbits contributes to the problem. A procedure is described in which excess soft tissue (fat, nasal muscles, and parts of the orbicularis oculi) are excised. A pulley canthopexy with a figure-of-eight suture of polypropylene is performed to bring the canthal tendons together using a hollow awl with a removable handle. The pulley gives a 4 to 1 mechanical advantage to the suture, adding control and distributing the forces over a wider area. The pulley canthopexy is a valuable tool not only in congenital anomalies but also for correcting long-standing traumatic telecanthus and acute detachment of the canthal ligaments.

Craniofacial Dysostosis↗
PubMed1980

Reconstruction of the burned nose.

Nasal reconstruction is one of the most important elements in rehabilitation of the patient suffering from the devastating deformities of full-thickness facial burns. When possible we use a single pedicle for complete nasal reconstruction. The forehead furnishes the best donor area. More distant donor sites are used if the forehead is not available. In lesser deformities, resurfacing with composite grafts or full-thickness skin grafts gives satisfactory results.

Aged↗
PubMed1979

Surgical safaris with the East Africa Flying Doctor Service.

A few hundred small mission and government hospitals serve the 20 million people who live in rural East Africa. The physician-patient ratio is 1:25,000. Surgical support to many of these hospitals is provided through the East Africa Flying Doctor Service of the African Medical and Research Foundation. Small aircraft that are coordinated by a wide radio network bring surgical capability to a maximum number of patients in this area of 1,300,000 sq km (500,00 sq miles). The clinical problems, differential diagnoses, operative decisions, risk, and complications of surgical care all have a distinctly African quality. The working conditions and variety and magnitude of problems provide a stimulating challenge. Surgical safaris are a catalyst for gaining acceptance of modern scientific methods by Africa's tradition-oriented tribesmen.

Aircraft↗
PubMed1979

Free microvascular flaps for defects of limbs, head, and neck.

Twenty-three free microvascular flaps were transferred during the period September 1975 to December 1978. These included skin flaps, osteocutaneous flaps, and flaps of omentum and jejunum. These flaps were used for a variety of conditions ranging from life-threatening bleeding from a tumor to facial contouring in congenital deformities. In selected patients a microvascular free flap has significant advantages over multi-staged conventional flaps.

Adult↗
PubMed1979

Operating room mirror for mammaplasty evaluation.

Patients undergoing augmentation mammaplasty are draped so that they can sit up during the operative procedure. With the help of a mirror, both patient and surgeon can view the new contours with trial prostheses before final closure is made. A more accurate evaluation of the result is gained, and changes can be made immediately.

Breast↗