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Biomedical subjects

D W Henderson

Publications and source records attributed to D W Henderson.

At least 55 records · Page 3Linked to original sources
PubMed1985

FMC-HU-1-B: a lymphoma B-cell line with unusual characteristics.

A cell line (FMC-Hu-1-B) was established from a biopsy of an abdominal mass of a child with non-Burkitt's lymphoma. The establishment of the cell line initially required the presence of normal bone marrow stromal cells and phytohaemagglutinin stimulated leucocyte conditioned medium. The cell line lacked Epstein-Barr virus nuclear antigen and exhibited numerous chromosomal abnormalities. Cell-surface marker analysis using a panel of monoclonal antibodies revealed only markers of the B lineage. Within the B-cell lineage FMC-Hu-1-B seemed to occupy a level of maturation equivalent to normal mature B-cells (surface membrane IgM, secretion of immunoglobulin and FMC-1 positive). However, the cells also weakly expressed the common acute lymphoblastic leukaemia antigen, normally found on early precursors of B-cells. The cells appear to secrete auto-stimulatory growth factor(s).

B-Lymphocytes↗
PubMed1984

The role of Swan-Ganz catheterization in severe pregnancy-induced hypertension.

Swan-Ganz catheterization was performed in 15 postpartum women who presented with severe pregnancy-induced hypertension at a mean gestational age of 31.5 weeks. The mean arterial pressure on presentation was 137.6 torr (range, 116 to 167 torr), and it remained at approximately 115 torr for the next 72 hours. Serial pulmonary capillary wedge pressure, cardiac output, and colloid oncotic pressure were obtained. The mean pulmonary capillary wedge pressure was 9 torr on insertion of the catheter, and it rose to 13 torr by 36 hours. Three patients whose pulmonary capillary wedge pressure was higher than the mean developed pulmonary edema. The mean colloid oncotic pressure was 14.14 torr. We found that hemodynamic monitoring and determinations of colloid oncotic pressure were useful additions to the clinical examination in the postpartum management of patients with severe pregnancy-induced hypertension. Our patients had a broad range of central volume status, cardiac output, and systemic vascular resistance, and the management was tailored accordingly. Although most patients had hyperdynamic pulmonary cardiac function, three developed edema at a lower pulmonary capillary wedge pressure because of decreased colloid oncotic pressure and possibly increased capillary permeability.

Adolescent↗
PubMed1984

Pigmented villonodular synovitis associated with psoriatic polyarthropathy: and electron microscopic and immunocytochemical study.

A case of pigmented villonodular synovitis in a patient with psoriatic polyarthropathy was studied by means of light microscopy, electron microscopy and immunocytochemical techniques. The lesion consisted of mononuclear phagocytes with features intermediate between type A and type B cells, two types of multinucleate giant cells, an abnormal vasculature, extravasated fibrin and erythrocytes. An unexpected feature was the presence of a mononuclear cell whose cytoplasm contained intermediate filaments and reacted strongly to antisera to cytokeratins. Such a cell type has not previously been described in this condition and its significance is unclear. The findings support the theory that the pathogenesis of PVNS involves leakage of blood through abnormal vessels resulting in the local accumulation and proliferation of mononuclear phagocytes, connective tissue cells and unidentified cytokeratin positive mononuclear cells. The aetiology of the vascular damage, however, remains unknown.

Adult↗
PubMed1984

Pulmonary asbestosis--an example of industrial diffuse lung disease.

This account reviews the clinical and pathological features of asbestosis, with a brief comment on the incidence of asbestosis in workers exposed occupationally to Western Australian crocidolite at Wittenoom Gorge. In keeping with common usage, the term "asbestosis" is restricted to pulmonary parenchymal fibrosis--with or without associated visceral pleural fibrosis--related to inhalation of asbestos fibres, thereby excluding parietal pleural fibrous plaques. The mechanisms underlying the development of the interstitial fibrosis are incompletely understood, but they appear to involve complex interactions of asbestos with alveolar macrophages, fibroblasts, lymphocytes and the complement system.

Asbestos↗
PubMed1984

The morphogenesis and classification of diffuse interstitial lung diseases: a clinicopathological approach, based on tissue reaction patterns.

This account gives a clinicopathological overview and classification of diffuse interstitial lung diseases, emphasising the interstitial pneumonias. The morphogenesis and progression of fibrosing alveolitis are discussed in relation to the normal cellular and extracellular components of the pulmonary interstitium, with the alveolar macrophage playing a pivotal role. So-called desquamative interstitial pneumonia is considered to represent an early steroid-responsive cellular exudative phase of fibrosing alveolitis, most of the intra-alveolar cells being macrophages rather than type II pneumocytes. The distinction between fibrosing alveolitis and diffuse alveolar damage, and their possible pathogenetic relationships to each other, are also discussed. Throughout this presentation it is stressed that inflammatory interstitial disorders such as the "desquamative" alveolopathies constitute stereotyped patterns of tissue reaction to a variety of injurious agents, which should always be taken into account in reaching a definitive clinicopathological diagnosis, especially in fibreoptic biopsies where histomorphological discriminants may not be present because of the small amount of tissue sampled.

Adult↗
PubMed1983

Malignant Schwannoma of cranial nerves.

The clinical presentation and histopathological features of 5 cases of malignant Schwannoma of cranial nerves are described. The ultrastructural appearances of one case and the pattern of nerve sheath cell differentiation of these tumours are also discussed. These uncommon tumours often are not diagnosed at initial presentation. Since the cases provide evidence that early diagnosis and surgical treatment are vital in the management of patients with this tumour criteria for its diagnosis are suggested.

Adult↗
PubMed1981

Electron microscopy in surgical pathology: a selective review.

The high resolution provided by electron microscopy can contribute to histomorphological diagnosis by allowing the detection of structures which are invisible to the light microscope. These structures include characteristic nuclear or cytoplasmic contours, intercellular attachments and intracellular components. The recognition of such features may allow specific diagnosis in lesions which cannot be precisely categorized by light microscopy. Electron microscopy is particularly useful for the diagnosis of neoplasms. This review describes some of the characteristic morphological features which can be demonstrated in neoplastic cells by electron microscopy and briefly considers several areas where the technique is of special value. Electron microscopy is now an integral part of the diagnostic process in surgical pathology and can be regarded as a routine technique rather than a special procedure to be delegated to others.

Adenocarcinoma↗
PubMed1979

Diurnal growth trends, water potential, and osmotic adjustment of maize and sorghum leaves in the field.

The daily cycle of leaf elongation rate, water potential, and solute potential of maize and sorghum, as well as temperature, were monitored in the field. Major climatic features were high radiation and a minimum air temperature of about 12 C. Leaf elongation of both crops was slowest at night, presumably because of low temperature. Peak elongation rates were in daytime when leaf water potential (Psi) was low. Solute potential also decreased during daylight, thus permitting the maintenance of appreciable turgor pressure, a critical parameter for cell expansion.Leaf Psi versus relative water content (RWC) curves were developed by sampling detached leaves at intervals as they dried quickly in the laboratory. At a given RWC, Psi was lower in leaves at midday than early in the morning, which is evidence that the decrease in psi. at midday was caused by an increase in the amount of solute in the tissue. Estimates of psi. at 100% RWC were 4 bars lower at midday than early in the morning in both crops. Soluble sugars, mainly nonreducing, accounted for most of the observed psi. decrease in sorghum leaves. Shading the leaves from light eliminated most of the solute buildup.

Journal Article↗
PubMed1979

Pulmonary lymphomatoid granulomatosis with immunodeficiency terminating as malignant lymphoma.

Lymphomatoid granulomatosis was diagnosed in a 60-yr-old woman 2 yr after presentation with a multi-system disorder resembling sarcoidosis. Five months later autopsy revealed malignant lymphoma. Large aggregates of intracytoplasmic tubular structures resembling nucleocapsid material of the paramyxovirus group were found within cells of lymphoma deposits in the liver. Sequential immunological studies over more than 2 years demonstrated a relatively stable T-cell deficiency associated with variable B-cell dysfunction. The latter was characterized by the production of immunoglobulins of restricted electrophoretic mobility. Intermittent hypercalcaemia was associated with increases in serum IgG and appeared to be due to the presence of Ca-binding paraproteins. It is suggested that lymphomatoid granulomatosis may be a pre-malignant lymphoproliferation, with immune deficiency as a predisposing cause. The pattern of immunological abnormalities suggests that the lymphoma may have been due to B-cell malignant transformation.

Female↗