Biomedical subjects
D W Kohn
Publications and source records attributed to D W Kohn.
Epidemiology and prediction of sports-related traumatic injuries.
All sports injuries, and this is certainly true of dentally related sports injuries, occur for predictable reasons. In some instances, these predictors have been well studied and are recognized by participants as well as coaches, dentists, and other responsible parties. In other instances, there is much to be learned about these predictors. There is no question that predictors have direct influence upon the incidence and prevalence data for dental injuries related to each sport. Because of the variability of these predictors from one sport to another, from one sports participant to another, from one age group to another, and even from on playground, field, or court to another, the importance and validity and usefulness of much of the data available currently is debatable. The importance of sports dentistry is not based solely on the urgency afforded by a given number of injuries among a specified number of participants over a certain amount of time. It is the predictable nature of these injuries and the need for the profession to take responsible action in their prevention and treatment that provides the strongest imperative for a sports dentistry movement.
Immunochemiluminometric assay of creatine kinase MB with a monoclonal antibody to the MB isoenzyme.
Previous two-site immunometric assays for creatine kinase (CK; EC 2.7.3.2) MB isoenzyme have been based on formation of a "sandwich" complex involving CK-MB and antibodies that recognize the CK-MM and the CK-BB isoenzymes. Single-incubation model assays of CK-MB with these antibodies were susceptible to interferences by CK-MM and CK-BB. We produced two anti-CK-MB monoclonal antibodies and studied their suitability for two-site assays. Both antibodies were compatible with anti-CK-MM and anti-CK-BB, but not with each other. Using anti-CK-MB as the tracer antibody eliminated the interference by both CK-MM and CK-BB. Labeling anti-CK-MB with acridinium ester and immobilizing anti-CK-BB on paramagnetic particles, we developed a rapid and highly sensitive chemiluminescent/magnetic separation CK-MB assay. As little as 1 microgram of CK-MB per liter was detectable after 10- or 30-min incubation at room temperature, and the standard curve was linear up to 400 micrograms/L. Results for serum samples by the new assay correlated well (r = 0.94) with those by Corning electrophoretic and the Hybritech Tandem-E immunoenzymometric CK-MB methods. Sera containing macro CK-1 or high concentrations of CK-MM and CK-BB did not interfere. The combined advantages of a more-specific antibody, paramagnetic solid phase, and chemiluminescent label endow this two-site CK-MB assay with performance characteristics and ease of use superior to those of previous assays.
Heck's disease (focal epithelial hyperplasia).
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The use of amphotericin B to increase the selectivity of media used for isolating oral lactobacilli.
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Dentists in a bubble.
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Twenty-one years of child advocacy: an editorial retrospective of the Teuscher years.
On the eleventh anniversary of his Editorship of JDC, Dr. George Teuscher took stock of the state of the Journal, noting progress made and challenges ahead, writing that, "A good journal cannot ride on its reputation... Constant effort to improve, resourcefulness, and prolific reading and study are required of the editor of a prestigious journal." He has written extensively on the importance of writing and effective communication in the face of an information explosion, stating that, "The journal is still the best means of presenting new information to the professions." Writing a note of encouragement to the editor of a new dental journal, he observed, "Of course the dental and medical literature can boast of some great editors, who earned their reputations because they were able to apply intelligence, writing ability, knowledge of the scientific method, and imagination to a new undertaking." After twenty-one years, it is safe to say that Dr. Teuscher is such an Editor; he has filled our minds with knowledge and our hearts with wisdom; he has reminded us of the best that is in us; he has helped us to feel the anguish of the afflicted and oppressed; he has brought knowledge and skill to help the infirm: and he has taught us to stand in awe before the mystery of being.
AIDS in dentistry.
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Hospital pediatric dentistry: at the crossroads again.
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