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Biomedical subjects

D W NEILL

Publications and source records attributed to D W NEILL.

At least 19 recordsLinked to original sources
PubMed1964

PATHOLOGICAL FINDINGS IN HOMOCYSTINURIA.

Pathological findings are described in four cases of a new aminoaciduria in which homocystine is excreted in the urine. All the patients were mentally retarded children. Three of them presented diagnostic features of Marfan's syndrome. Necropsy on one case and biopsy findings in the others are described. Fatty change occurs in the liver. The most striking lesions are vascular. Metachromatic medial degeneration of the aorta and of the elastic arteries in the necropsied case are considered in relation to Marfan's syndrome. Other changes, particularly thrombosis which is prevalent in homocystinuria, suggest the possibility of a platelet defect. The findings are discussed in respect of an upset in the metabolism of sulphur-containing amino-acids and with particular reference to Marfan's syndrome.

Adolescent↗
PubMed1960

The effects of corticotrophin and corticoids on secretion from denervated gastric pouches in dogs.

The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosity, and pH were measured, and the concentrations of hydrochloric acid, pepsin, sodium, potassium, and chloride estimated. In the pharmacological doses used all the substances produced similar effects. Volume and acidity of the secretion were increased and there was a decrease in the viscosity of the basal secretion. The concentration of pepsin and of sodium and potassium were decreased while the chloride concentration was unaffected. Cortisone (the only steroid tested in this respect) increased the maximal secretory response to histamine. Three to five days elapsed before any change took place in the secretion. The effects observed were independent of the glucocorticoid or mineralocorticoid activity of the particular hormone used and were probably due in some measure to a 50% increase in parietal cell population, associated with a 36% decrease in peptic cell population, which was demonstrated histologically.

Adrenal Cortex Hormones↗
PubMed1960

Effect of glucagon on gastric secretion in the dog.

The effects of glucagon on gastric secretion in the dog have been studied. Gastric juice was collected both from denervated and innervated pouches under basal conditions and when the animals were stimulated by meat extract and by histamine. In the dogs with innervated pouches psychic stimulation and the stimulatory action of insulin-induced hypoglycaemia were also used. Glucagon reduced the volume but not the acidity of gastric juice collected under all conditions. This effect was independent of its hyperglycaemic action and occurred when physiological doses were administered.

Animals↗