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Biomedical subjects

D W Noller

Publications and source records attributed to D W Noller.

6 recordsLinked to original sources

The effects of vasectomy on testicular metabolism in the guinea-pig.

The effects of vasectomy on testicular DNA production were studied in guinea-pigs at 2 weeks and 2 and 6 months after surgery. By 6 months, vasectomy had resulted in lower testicular weight and absolute DNA, RNA and protein contents, although RNA and DNA concentrations/protein were unchanged. Incorporation of thymidine into the testis had decreased by 2 weeks after vasectomy, and continued to do so unless the ductal system subsequently ruptured and formed a granuloma when thymidine incorporation returned to normal control levels. It is suggested that in the guinea=pig vasectomy alters spermatogenesis by reducing testicular DNA synthesis.

Animals↗

Intercostal nerve block with flank incision.

We studied the postoperative course of 20 consecutive patients with T10 to 12 flank incisions, half of whom had intraoperative bupivacaine intercostal nerve blocks. The nerve block patients required less pain medication (p less than 0.001), ambulated 3 days earlier (p less than 0.001) and took a regular diet 2 days sooner (p less than 0.01) than the control patients.

Abdomen↗

Metabolic effects of unilateral orchiectomy on the guinea pig testis.

Six months after unilateral orchiectomy, there was a significant increase in the RNA and DNA content of contralateral testes as compared with the testes of age-matched normal guinea pigs. The ratio of RNA to DNA was not affected by orchiectomy, suggesting that the compensatory growth was secondary to hyperplasia rather than hypertrophy. Tritiated thymidine uptake by the contralateral testis was elevated at 2 weeks and 2,4 and 6 months after orchiectomy, confirming that increased metabolic activity occurred in the remaining testis after hemicastration.

Animals↗

Duration of the seminiferous epithelial cycle in the mature guinea pig: influence of unilateral orchiectomy.

The effect of unilateral orchiectomy on the seminiferous epithelial cycle in the mature guinea pig was studied. No significant change in the cycle duration was found. Thus, the previously reported hyperplasia of the contralateral testis is due to an increased number of cells entering the maturation process rather than to an acceleration of the cycle of seminiferous epithelium.

Animals↗