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D W SMITH

Publications and source records attributed to D W SMITH.

At least 19 recordsLinked to original sources
PubMed1964

RELATIONSHIP OF MYCOSIDE CONTENT AND COLONY MORPHOLOGY FOR GROUP 2 AND GROUP 3 UNCLASSIFIED MYCOBACTERIA.

Navalkar R. G. (University of Wisconsin, Madison), E. H. Wiegeshaus, and D. W. Smith. Relationship of mycoside content and colony morphology for group II and group III unclassfied mycobacteria. J. Bacteriol. 88:255-259. 1964.-The relationship between colony morphology and mycoside content previously reported for Mycobacterium kansasii and M. fortuitum does not extend to group II and group III unclassified mycobacteria. Mycoside distribution studies permit a division of group II cultures into three subgroups: mycoside D group, mycoside Cm group, and a group containing no mycoside. The colony form of group II and group III isolates is more definitive on oleic acid-albumin-agar than on Corn Meal Agar. Attention is called to the differences in colony form and mycoside content for subcultures of M. marianum obtained from two sources.

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PubMed1964

INDUCTION OF ACQUIRED RESISTANCE IN GUINEA PIGS WITH DEFATTED MYCOBACTERIUM TUBERCULOSIS VACCINES.

Smith, D. W. (University of Wisconsin, Madison), G. B. Fregnan, L. DeLaquerriere-Richardson, and E. Valdivia. Induction of acquired resistance in guinea pigs with defatted Mycobacterium tuberculosis vaccines. J. Bacteriol. 88:87-92. 1964.-Residues of mycobacteria exhaustively extracted with neutral organic solvents have been shown to produce a level of resistance against tuberculosis in guinea pigs comparable to that produced by BCG. Disruption of defatted tubercle bacilli in adjuvant eliminated the acid-fast staining property of the residue, but immunizing and sensitizing properties were retained in the fraction which sedimented at 44,000 x g. To demonstrate these activities with 50 mug of vaccine, it was necessary to use Bayol-Arlacel adjuvant. A similar quantity of vaccine given in saline was inactive. A defatted vaccine prepared from a virulent strain of Mycobacterium tuberculosis recently passed through a guinea pig was significantly more immunogenic than a similar vaccine prepared from H37Ra.

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