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Biomedical subjects

D W Vere

Publications and source records attributed to D W Vere.

12 recordsLinked to original sources
PubMed1991

The basis of the histamine assay in skin.

1. The assay of wheal response to histamine injected sub-epidermally has been reviewed. Several discrepant claims were found in earlier work. 2. The saline control injection may evoke a wheal, which if present should be allowed for in the assay procedure. 3. There was no evidence for a limb dominance effect. 4. Using a 3.26 mM (1 mg ml-1) standard solution of histamine acid phosphate (1.18 mM as free base) and 0.1 ml injections, the straight central portion of the assay curve was found to be between 0.3 and 2.3 x 10(-3) mM, as free base, with an ED50 of about 0.018 mM histamine base.

Histamine↗
PubMed1978

A longitudinal study of the mechanisms of action of debrisoquine and propranolol.

1 The mode of action of hypotensive drugs is not necessarily the same early and late in a course of treatment. 2 It was aimed to study this possible difference of effects for the drugs debrisoquine and propranolol, using a clinical trial design and measuring as many cardiovascular functions as possible by noninvasive methods in out-patients. 3 Several well known effects of these drugs were noted; in addition it was found that in some subjects there was a small but progressive salt retention during propranolol treatment, that the displacements of the slopes in baroceptor function tests were different for the two drugs tested, and that venous distensibility was reduced at first with propranolol but soon increased again. 4 It is useful to combine longitudinal measures of body functions with a clinical trial when studying mechanisms of drug action.

Adult↗
PubMed1978

Testing new drugs--the human volunteer.

Professor Duncan Vere lays before us the idealised guidelines used for recruiting volunteers on which to try and test new medicines. He points out that if these were followed rigidly, few, if any volunteers would be found for this vital work. Inducements are used, but the size of these determines whether society deems it right or wrong. However, the aim is to help and advise volunteers of the need for such tests and the risks involved and therefore the information leaflet reprinted as part of the article indicates how the drug testers are attempting to encourage volunteers in as ethical a way as possible. To abandon human tests with new drugs may be unethical. A balance is sought.

Disclosure↗
PubMed1978

The design of pharmacological experiments using unbiased models of agonist-antagonist interaction.

The methods which exist to represent agonist-antagonist interactions, and to distinguish between them are sufficient and effective. Their effective use depends on a set of criteria which are not always fulfilled in actual experiments. In some situations it is difficult or impossible to meet these criteria. An alternative representation is proposed, using straightforward geometry, which evades this problem. It also allows experimental data points to be selected without bias and makes it possible to apply orthodox criteria to more restricted sets of data than is otherwise the case. To do this, it is necessary to reverse the ordinary procedure in antagonist assays, by adding successive concentrations of antagonist to a preparation so that a constant response is evoked by squared multiples of the original agonist dose. This can only be done with rapidly reversible antagonists, but the method has been shown to be effective for such drugs.

Drug Antagonism↗