PubMed Health⌕ Search

Biomedical subjects

D W Wingard

Publications and source records attributed to D W Wingard.

At least 19 recordsLinked to original sources
PubMed1979

High-performance liquid chromatographic separation and detection of catecholamines and related compounds.

Four sets of chromatographic conditions are described for the separation and identification of selected catecholamines and related chemicals by high-performance liquid chromatography. Three mobile phases, three different columns and three detection systems, including ultraviolet absorption, fluorescence and electrochemical detection are reported. The use of detection response ratios as an additional means of identification is discussed and demonstrated. Nineteen compounds were studied and the retention times and detector responses are reported.

Catecholamines↗
PubMed1979

Malignant hyperthermia. A potentially fatal syndrome in orthopaedic patients.

Malignant hyperthermia is an inherited muscular disorder and a cause of sudden death in afflicted patients. Stress arising from tramuma, surgery, and other causes can initiate the syndrome. We studied the types of orthopaedic problems commonly seen in patients with this condition as well as the clinical manifestations and pathophysiology of the syndrome. Recognition, management, and understanding of the pathophysiology of malignant hyperthermia can be aided by a study of its similarities to porcine stress syndrome. We performed experimental studies of muscle and prophylaxis in swine. We also demonstrated the extension of the prophylactic use of dantrolene sodium in a management protocol in eighty surgical procedures in humans.

Adult↗
PubMed1975

Prevention of porcine malignant hyperthermia by epidural block.

Malignant hyperthermia in susceptible swine was completely blocked by epidural anesthesia with lidocaine. Incomplete epidural anesthesia modified the disease but did not prevent it. These studies indicate the importance of the nervous system in the triggering of malignant hyperthermia. (Key words: Hyperthermia, malignant; Anesthetic technique, peridural.).

Anesthesia, Epidural↗