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Biomedical subjects

D Werchan

Publications and source records attributed to D Werchan.

13 recordsLinked to original sources
PubMed1990

[Comparative study of parenteral and oral immunization against influenza in a large clinical trial. 2. Results of immunologic studies].

In a multicentric trial 350 persons (19-24 years) were immunized with influenza vaccines containing the following virus antigens: A/Singapore/6/86, (H1N1); A/Mississippi/1/85, (H3N2); B/Ann Arbor/1/86. 174 received an i.m. injection of 0.5 ml "Influmun" vaccine from SSW Dresden/GDR. 176 persons were immunized twice within 60 days with enteric-wated capsules each containing approximately 60 micrograms hemagglutinin of all three virus strains. The volunteers were clinically observed in an interval of 6 months. The majority of orally immunized persons with low pre-immunization titers responded with fourfold or higher IgA antibody titer rises in nasal secretions, but no significant IgG antibody titer increase in sera could be observed. Secretory antibody titers remained elevated for 2 to 4 months. Parenterally immunized persons showed antibody titer rises in sera but not in nasal secretions. In both groups the highest antibody titer increases were observed after application of the A/Singapore/6/86 virus antigen. Volunteers with high pre-immunization titer did not show an antibody increase neither after parenteral nor oral immunization.

Administration, Oral↗
PubMed1990

[Comparative study of parenteral and oral immunization to influenza in a large clinical trial. 1. Results of clinico-epidemiologic studies].

360 volunteers were recruited for the investigation from a homologous collective. 174 were immunized parenterally with "Influmun" from SSW Dresden, GDR. 176 volunteers were immunized twice orally with an interval of 60 days with an influenza vaccine inactivated by x-ray using enteric-coated capsules. In an interval of six months ARI-symptoms were investigated. Between 13th and 17th week 1988 an increased ARI-morbidity in the Greifswald-region was observed in which influenza A viruses were involved. In comparison with 312 non-immunized persons of the same age, sex and living area the immunized volunteers of the two groups showed 83.4% less sickness days. 30 persons of the non-immunized group got ill for totally 217 days, whereas only nine persons of the two immunized groups were put on the sicklist for totally 36 days. No significant differences concerning the occurrence and duration of acute respiratory infections (ARI) between the two differently immunized groups could be observed.

Administration, Oral↗
PubMed1990

[Oral administration of "Infectvac" for prevention of acute respiratory tract infections].

The efficacy of a newly developed polyvalent bacterial lysat vaccine "Infectvac" was tested in experimental studies in animals. It was shown that a local application (oral, aerogenic) prevent the animals from a lethal bacterial (S. pneumoniae) or viral (A/PR/8/34) infection. In first clinical trials a good compatibility of the drug was demonstrated.

Administration, Intranasal↗
PubMed1986

[Radiation-induced changes in the properties of gelatin].

The impact of high energetic rays between 10 and 100 kGy on gels and solutions of gelatin is studied. Physical and biopharmaceutical properties are changing dependent on the rayage and the content of glycerol and water. The possibilities of influencing melting behaviour, viscosity, rigidity, temperature of gel formation, imbibition behaviour and dissolution in foillike preparations are determined. Glycerol is able to compensate the radioinduced changes of the structure of gelatin up to a dose of 50 kGy. Its use as a radioprotective material is being discussed.

Adsorption↗
PubMed1978

[Treatment of prosthesis stomatitis with antimycotic foils].

The therapy of denture sore mouth which is induced by Candida albicans must take its bearings about the general and local disposition factors. The crucial points of stomatological treatment are pointed to. The problems related to local antimycotic therapy in the oral cavity are discussed. A new antimycotic dosage form, the nystatin-gelatin foil, for local application in denture wearers in presented. Its dosage and its use are described.

Administration, Topical↗
PubMed1978

[The manufacture of nystatin-gelatin foils for the treatment of denture stomatitis].

The authors describe the formula and the manufacture of nystatin-gelatin foils that are a new dosage form for local application in case of denture sore mouth induced by Candida albicans. It is pointed to the requirements that a pharmaceutically used gelatin should meet. Furthermore, the authors discuss biopharmaceutical aspects of the nystatin-gelatin foil.

Candidiasis, Oral↗