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Biomedical subjects

D Wiesenfeld

Publications and source records attributed to D Wiesenfeld.

At least 37 records · Page 2Linked to original sources
PubMed1994

Temporomandibular pain dysfunction disorder resulting from road traffic accidents--an Australian study.

The relationship between temporomandibular pain dysfunction disorder (TMPD) and trauma to the head and neck is unclear. A retrospective analysis of the records from the Transport Accident Commission (TAC) of Victoria, Australia, in the year 1987, was done to identify those subjects who received treatment for TMPD resulting from a road traffic accident (RTA). Twenty-eight subjects with TMPD were identified from a total of 20 673 subjects who claimed health care services from the TAC for RTA-related disorders. In this study, TMPD for which subjects sought treatment was uncommonly associated with either direct or indirect trauma to the temporomandibular joints: 0.4% of subjects with mandibular fractures and 0.5% of subjects with whiplash injuries presented for treatment of an associated TMPD. Females were found to present for treatment of TMPD more commonly than males at a ratio of 5:2. It was also noted that 75% of subjects complained of symptoms of TMPD immediately after the accident and approximately 96% within 2 months of the accident. Subjects were not lost to follow-up because all claims for treatment were made to the TAC, regardless of the clinician involved. In this study, 25% of subjects attended more than one dentist for management. It was concluded that TMPD for which subjects sought treatment was an uncommon result of an RTA and was infrequently associated with a mandibular fracture or whiplash injury.

Accidents, Traffic↗
PubMed1994

Maxillary giant cell tumour associated with Paget's disease of bone.

A case involving the rare occurrence of a maxillary giant cell tumour in association with Paget's disease is reported. Surgical treatment consisted of a combined intraoral and temporal approach for tumour resection with temporalis muscle flap reconstruction of the maxilla. The postoperative course was complicated by a recurrence.

Diagnosis, Differential↗
PubMed1994

Improving the accuracy of orthognathic surgery.

The advent of modern techniques for the correction of facial deformity has allowed oral and maxillofacial surgeons to routinely perform facial bone osteotomies to correct facial deformities and malocclusions. As these techniques have become more commonplace there is an ever increasing need for accuracy to fulfil the expectations of patients, orthodontists, and surgeons. Attention to detail is 'the name of the game'. This paper will highlight points of detail in the preparation, planning, and execution of facial bone osteotomies to improve the outcome for patients with facial deformities.

Humans↗
PubMed1993

Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists.

Although it is established that the immunosuppressant cyclosporin-A (CsA) and calcium antagonists [Nifedipine (Nif) and Diltiazem (Dz)] can independently induce gingival enlargement, little has been documented on the significance of the salivary CsA levels and the combined effect of CsA and a calcium antagonist upon gingival tissues. In the present cross-sectional investigation, clinical periodontal parameters and the pharmacologic profiles of CsA, Nif, and Dz were determined for 66 renal transplant recipients. Subjects were divided into the following groups: Group (Gp) 1: CsA [n = 18]; Gp 2: CsA + Nif [n = 15]; Gp 3: CsA + Dz [n = 12] and a negative Control Gp 4: azathioprine [n = 21]. A gingival enlargement score was assessed for each patient from study models using a hyperplastic index (HI). Pharmacologic profiles included CsA whole blood and whole saliva levels as measured by fluorescence polarization immunoassay. The HI scores between Gp 1, 2 and 3 were not significantly different. However, when compared with controls (Gp 4), there was a significant difference in HI and all individual groups (Gp 1, 2, 3) (p < 0.05). Gingival hyperplasia was only weakly related to plaque and calculus but was unrelated to CsA dose (mg/kg/day), duration of CsA therapy (months), CsA blood or saliva levels (ng/ml), or the concurrent administration of a Nif or Dz. Gingival enlargement was found to occur in 49% of subjects who were either on CsA or CsA and a calcium antagonist. It is concluded that CsA alone or in combination with a calcium antagonist caused a significant increase in gingival enlargement compared with controls.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Referral patterns of patients with oral squamous cell carcinoma, Australia.

Early diagnosis is an important factor affecting the prognosis of patients with oral cancer. Delays in diagnosis have been variously reported as being linked to the patient, the clinician or both. The purpose of this study was to investigate the referral patterns of patients with oral cancer by medical and dental practitioners, in order to assess the delays in diagnosis and to establish the reasons for these delays. 51 consecutive patients diagnosed with oral mucous membrane squamous cell carcinoma were retrospectively reviewed. In this study it was found that over one-third of the patients (38%) delayed seeking professional advice for more than 3 months after first being aware of the lesion. Initial delays in diagnosis of oral cancer was identified in one-third of the cases (17 patients), with antimicrobial medications prescribed and denture adjustments constituting the most frequently administered inappropriate therapy. General medical practitioners were more likely to encounter and refer patients with more advanced (T4) primary oral cancers than their dental colleagues. The findings of this study raise the concern that lack of patient awareness and inappropriate clinical management prevails in a community that should be better informed.

Adult↗
PubMed1985

Pseudomalignant osseous tumor of the temporalis muscle.

A case is presented of a 10-year-old girl who had a benign osseous tumor of the temporalis muscle. The tumor appeared to be a variant of the so-called pseudomalignant osseous tumor of the soft tissues and could readily be distinguished from both osteogenic sarcoma and myositis ossificans.

Child↗
PubMed1985

Lichen planus and liver disease: how strong is the association?

One hundred and thirteen patients with histologically confirmed oral lichen planus, from three stomatology clinics, were examined for evidence of liver disease. No patient had clinical evidence of liver disease. Nine patients (7.9%) had a raised serum concentration of a single enzyme; 6 patients had raised gamma-glutamyl transpeptidase, 2 had raised alkaline phosphatase, and 1 had raised aspartate transaminase levels. No patient had serum auto-antibodies suggestive of primary biliary cirrhosis or chronic active hepatitis. Most patients presenting with oral lichen planus are unlikely to have liver disease.

Adolescent↗
PubMed1985

Oro-facial granulomatosis--a clinical and pathological analysis.

A study of 60 patients with oro-facial granulomatosis has been conducted and the clinical presentation of this disorder defined. It encompasses the previously recognised clinical entities of Melkersson-Rosenthal syndrome and cheilitis granulomatosa. The pathological features of the disease are lymphoedema and the presence of multiple non-caseating giant cell granulomata. These granulomata are histologically indistinguishable from those found in both gastrointestinal Crohn's disease and systemic sarcoidosis. Within this series of patients, nine had evidence suggestive of gastrointestinal Crohn's disease, and in six this was confirmed. A diagnosis of sarcoidosis was made in a further two patients. The relationship of oro-facial granulomatosis to these systemic granulomatous diseases is not yet clear. Patients with oro-facial granulomatosis who have gastrointestinal symptoms should be investigated for the presence of gastrointestinal Crohn's disease. Those without symptoms should be investigated for evidence of malabsorption or serological evidence of Crohn's disease. Within the present study, the erythrocyte sedimentation rate, full blood count, corrected whole blood folate, serum albumin and calcium were the most sensitive markers of gastrointestinal involvement. Sarcoidosis should be considered in all patients with oro-facial granulomatosis. The absence of clinical signs suggestive of sarcoidosis, a normal chest radiograph and normal levels of serum angiotensin-converting enzyme makes sarcoidosis unlikely.

Adolescent↗
PubMed1984

Allergy to dental gold.

Allergy to gold dental appliances in very rare. This article reports the case of a patient who presented with acute oral ulceration following the placement of a gold crown. Biopsy of the ulcer and adjacent mucosa showed histologic features typical of a contact sensitivity. The patient subsequently had a positive patch test reaction to gold chloride. The literature is reviewed, and the dental implications are discussed.

Crowns↗
PubMed1984

Pulsating exophthalmos associated with neurofibromatosis.

A patient with pulsating exophthalmos is presented. He had facial asymmetry, multiple cutaneous café-au-lait spots and a subcutaneous nodule, biopsy of which showed features consistent with neurofibromatosis. Radiographs of the orbit showed a deficiency of the superolateral orbital wall, a feature previously recognized as part of neurofibromatosis. This feature probably occurs as a result of mesodermal dysplasia. The differential diagnosis and management are discussed.

Adult↗
PubMed1984

Study of the ductal epithelial cell component of human labial salivary glands in vitro.

Salivary gland cultures were propagated from primary explant cultures of 55 human labial gland biopsies. Cultures were maintained for at least 7 days in 199 medium plus 20% newborn calf serum and growth measured at this time both by cell counting and planimetry of the area. Ductal cell population identification was undertaken on the basis of an intra-cellular function, the latter being the histochemical detection of the enzyme 11 beta-hydroxysteroid dehydrogenase. Epithelioid cell lines were derived by enzymatic and mechanical means. Non-invasive quantitation of the proportion of ductal epithelial cells present in primary explant cultures, and derived cell lines, was attempted using a radioimmunoassay to detect conversion in the media of cortisol to cortisone. The cell lines were terminated after undergoing 18 passages over 20 weeks. By this time the epithelioid morphology of cells could no longer be equated to a differentiated epithelial cell origin since conversion of cortisol to cortisone in the growth media no longer occurred.

11-beta-Hydroxysteroid Dehydrogenases↗
PubMed1983

Simultaneous computed tomography and sialography of the parotid and submandibular glands.

A technique of simultaneous computed tomography and sialography of the parotid and submandibular glands is described and the examination of 14 patients reported. Tumours were diagnosed in six cases and in the remaining eight cases inflammatory lesions were found. Sialographic enhancement offered definite advantages in localisation of lesions and examination of the tumour-normal tissue interface compared with either C.T. or sialography alone.

Humans↗