Biomedical subjects
Publications and source records attributed to D Willard.
A case of supracardiac total anomalous pulmonary venous drainage (TAPVD) in an infant aged 2 1/2 months is presented. Diagnosis was established non invasively by magnetic resonance image (MRI). Not only did MRI precisely depict the anomalous venous pathway but it moreover securely excluded pulmonary venous obstruction.
The case of a young child who demonstrated extrinsic narrowing of the thoracich trachea related to a mediastinal bronchogenic cyst is reported. Diagnosis was made by magnetic resonance imaging. About this case report, the authors review the possible causes of tracheal narrowing at this age of life and suggest a simple diagnostic management protocol.
Biological markers of neonatal bacterial infection are useful if they bring early indications and if they are sensitive and specific. There are two kinds of tests: hematological signs and acute phase proteins. The most specific hematological signs are, in chronological order: leuconeutropenia--myelemia--neutrophilic polynucleosis. Gestational and post-natal ages have to be taken in consideration for correct interpretation of white cell count and differential. Several acute phase proteins increase in infected newborns: fibrinogen, C reactive protein, orosomucoïd. If determined quantitatively, C reactive protein is a sensitive, specific and early marker allowing, in addition, to follow the reaction to treatment: the return to normal range of CRP and later of orosomucoïd attest for recovery. These biological tests have to be sequentially determined during the first days in order to obtain a maximal information.
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The authors report the case of a 3-month-old infant with a history of interventricular septal defect with pulmonary arterial hypertension. This child had pulmonary symptomatology (dyspnea, recurrent bronchitis, acute attacks of asphyxia) which it was possible to link to a retrotracheal left pulmonary artery by magnetic resonance imaging (MRI). Classical investigations (upper GI barium series and chest X-ray) were suggestive of a bronchogenic cyst type abnormal pulmonary structure. Angiography confirmed the MRI diagnosis. In this case the infant also had tracheal lesions (lower tracheal hypoplasia) which required further evaluation by fibroscopy and bronchography. Thus MRI shows itself to be a useful investigation in the study of basic vascular abnormalities.
Between February 1988 and July 1989, the authors used magnetic resonance imaging (MRI) to study 54 newborn infants aged between 2 and 35 days and suspected of congenital heart disease. All children also underwent echocardiography and 7 angiography during the neonatal period (13% of children studied). MRI was well tolerated and there were no adverse events. MRI proved to be complementary to echocardiography in several lesions affecting the great vessels of the base and the left atrial region. Agreement between angiography and MRI results was very good, with MRI being more useful in one case. MRI enables full and non-invasive postoperative follow-up. In conclusion, despite the great heterogenicity of the cardiac malformations studied and which requires a degree of caution, the authors feel that MRI is a second line investigation after echocardiography. It may limit the indications of angiography. Its own indications are the retrocardiac region, the main arteriovenous vessels of the base and postoperative follow-up in congenital heart disease. The development of techniques such as angio RM will further modify data in the future.
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The authors report a case of neonatal echovirus encephalitis associated with white matter necrosis. The pattern of illness in the neonatal period was diphasic, marked by hyperthermia and the occurrence of seizures. Echovirus was recovered from the cerebrospinal fluid. Cerebral magnetic resonance imaging (MRI) performed at one month of age showed right periventricular white matter necrosis. The infant exhibited mild left hemiparesis. Cerebral MRI at 6 months of age showed a delay in myelination in the right hemisphere. Echovirus encephalitis in the neonate can cause brain damage.
The authors report their experience of cerebral magnetic résonance imaging (MRI) in the neonatal period. MRI offers many advantages compared to CT scan or ultrasonography in the study of malformations, tumors, infections and anoxic-ischemic brain injury. However, MRI is limited by the duration of the examination the need for total immobility which is achieved in the neonate via administration of chloral hydrate, and lack of accessibility. MRI is a non invasive method for following in vivo brain development during infancy.
Three cases of renal dysfunction at birth were observed in premature babies exposed in utero to prostaglandin synthetase inhibitors (PSI) and corticosteroids. Transient water and sodium retention with uraemia occurred in one patient, and severe acute renal failure with marked hyperkalaemia in twins. These findings may be due to impairment of prostaglandin (PG)-mediated renal adaptation to stress conditions after transplacental passage of PSI. Corticosteroids may also have affected PG synthesis inhibition.
Ultrasonographic examination of the subcutaneous course and exit site of the Tenckhoff catheter in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) was performed to evaluate catheter-related infections. Real-time ultrasound studies were performed in 24 patients with initial exit-site infections; clinically suspected tunnel infections were excluded from analysis. A peri-catheter sonolucent fluid collection, considered a positive study, was demonstrated in 13 ultrasound examinations and tended to be organism-specific; eight of 12 Staphylococcus aureus exit-site infections and three of four gram-negative exit-site infections had positive studies. Only two of seven Staphylococcus epidermidis exit-site infections were initially positive on ultrasound examination. Nine of 13 patients with positive ultrasound studies ultimately lost their catheters to infection despite weeks of parenteral antibiotic therapy and local incision and drainage. There were 11 negative ultrasound studies. Only one of these patients' catheters was lost because of infection. In some episodes of CAPD-associated exit-site infections, especially those caused by S aureus and gram-negative organisms, ultrasound examination of the catheter course may be useful to diagnose unsuspected tunnel infections, direct early therapy, and confirm resolution or persistence of the infections.
Percutaneous pulmonary valvuloplasty was performed successfully in two neonates with cyanotic tetralogy of Fallot. It seems that balloon valvotomy may represent a palliative therapeutic alternative of choice in the neonatal period.
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Acyclovir (ACV), an antiviral nucleoside analog, is active against Herpes simplex viruses (HSV1, HSV2) and varicella virus (VZV). These viruses seems to be prejudicial to the pregnant woman and to the fetus. Yet, ACV is not recommended for use in pregnancy. However in certain cases, this drug has been used. We review in this paper, the pharmacokinetics and transplacental passage of ACV, indications, and whether the benefits of the administration of ACV in pregnancy outweigh the theoretical risks. Peak and trough plasma concentrations of ACV in pregnant women seem to be lower as compared to those of non-pregnant adults but effective. This drug crosses the placenta. Levels of ACV in cord blood ranged from 0.5 to 3 mumol/l. In as much as in vitro inhibitory doses 50 (ID 50) for HSV1, HSV2 and VZV ranged from 0.1 to 3 mumol/l, it is quite likely that levels noted above may be effective for in utero inhibition of viral replication. No adverse effects were noted in newborn exposed in utero to ACV. But one must be careful about the direct effects of this drug on nucleic acid metabolism despite encouraging results on animal fetuses. Based on these findings and from our experience, ACV can be administered in pregnancy in two particular situations: in cases of maternal severe viral infections and in order to inhibit in utero VZV replication. Doses required for pregnant women range from 5 to 15 mg/kg/8 hours given intravenously, and 200 mg of oral Acyclovir 5 times daily.
In contrast to widespread opinion, recent statistical data show that children born to mothers surviving from malignant diseases have a good outcome if radiotherapy has been avoided during pregnancy. Current chemotherapeutic agents are well tolerated by the developing fetus even in the first trimester of pregnancy. Offspring of patients treated for cancer in childhood bears no more risks of cancer than controls with the exception of the rare cases of hereditary predisposition to cancer.
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The authors report the case of a 34 weeks premature infant presenting a transpositions of the large vessels, who underwent a Rashkind during the neonatal period, a Senning procedure at three months, and was explored and followed-up by magnetic resonance imaging (MRI). The images obtained are of good quality, permitting a precise diagnosis of transposition of the large vessels and visualization of an inter-ventricular communication (IVC) which were missed on ultrasonography. The MRI shows complete images of the Senning correction and permits a non-invasive post-operative monitoring of this correction. MIR is therefore an interesting second intention examination which may effectively complement ultrasonography and limit the indications of angiography.