Biomedical subjects

D Winikoff

Publications and source records attributed to D Winikoff.

8 recordsLinked to original sources

PubMed1975

The one-step approach to thyroid function tests. The diagnostic thyroxine ratio (DTR)/serum thyroxine (T4) level combination.

A one-step approach to thyroid function tests is reported, using Tetralute kits (Ames). Two parameters are obtained simultaneously--namely, the serum thyroxine (T4) level and the diagnostic thyroxine ratio (DTR), which correlates well with the free thyroxine index (FTI) as determined by two separate tests-the T4 level and the triiodothyronine resin uptake ((T3U)) estimations. Data presented from patients with a variety of thyroid states prove that the DTR, particularly in combination with the T4 level, is adequate for the assessment of thyroid dysfunction in almost all circumstances.

Adolescent↗

PubMed1975

Variations in thyroid function and sleep in healthy young men.

1. The total serum thyroxine, tri-iodothyronine resin uptake, total plasma protein concentration and the free thyroxine index (FTI) were determined repeatedly, at 07.15, 13.00 and 22.30 hours over 4 days, in six healthy young men. 2. There was a significant diurnal variation in the total serum thyroxine concentration but this reflected changes in the binding capacity of serum proteins and in the total plasma protein concentration which could be explained by changes of posture. The FTI, and presumably therefore the free thyroxine concentration, varied very little with the time of day. 3. The FTI varied significantly from day to day in three of the six subjects, presumably as a result of changes in thyroxine secretion because the serum binding capacity did not vary. 4. The subjects' sleep at night was assessed by electro-encephalogram. In days when the FTI was highest for a particular subject his sleep was more fragmented by spontaneous awakenings, the amount of rapid-eye-movement sleep was reduced and that of delta-wave sleep was increased, implying that variations in thyroid function over a period of a few days in healthy subjects can be of physiological significance. The cause of these variations is uncertain.

Adult↗

PubMed1975

The predictive value of thyroid "test profile" in habitual abortion.

A characteristic thyroid test profile is observed in pregnancy; it consists of an elevated serum thyroxine (T4I), thyroxine binding globulin (TBG) and electrophoretic index (EI) with lowered triiodothyronine resin uptake (T3U), the free thyroxine index (FTI) remaining in the normal range. An investigation was made of progressive changes in these parameters in 70 normal pregnant women, 34 pregnant women with a past history of habitual abortion who carried to term, seven habitual aborters who miscarried again, and 49 women at the time of spontaneous miscarriage. The results indicated that normal women reached a typical pregnancy thyroid test profile at seven to eight weeks' gestation while habitual aborters carrying a pregnancy to term reached it at 14 to 15 weeks and almost all patients who miscarried never reached it at all. In addition, four women who had aborted previously and were treated with thyroxine throughout six pregnancies, developed a normal "thyroid profile" and carried their pregnancy to term. The significance of the "predictive value" of the test profile is discussed.

Abortion, Habitual↗

PubMed1972