D Witkowska — Page 4 | PubMed Health

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Alteration of brain noradrenaline, dopamine and 5-hydroxytryptamine levels during vanadium poisoning.

Effects of subacute and chronic intoxication with vanadium on the levels of noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT) were examined. It was shown that subacute as well as chronic intoxication caused changes in levels of biogenic amines in the rat brain. NA concentration decreased whereas DA and 5-HT levels significantly increased. Vanadium in concentrations of 10(-3) and 10(-4) M inhibited the uptake of 3H-NA by cerebral cortex slices in vitro.

Animals↗

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Influence of age on the discrimination of barium in comparison with strontium during their incorporation into compact bone.

This work describes the results of investigations on whole body discrimination of 133Ba as compared to 85Sr and discrimination in specific portions of long bones. The examinations, conducted in two groups of rabbits young and adult ones, were aimed at determination whether the discrimination of heavy alkaline earth element 133Ba is greater or smaller in young rabbits than in adults ones. It was found that whole body discrimination of 133Ba, as well as the discrimination in specific portions of bones, is greater in young than in adult animals. The study shows, therefore, that the discrimination predominates in the addition process, i.e. in the process of formation of new bone mineral, and is not predominating in the process of augmentation, i.e. in slow ion exchange in compact bone material. This conclusion was based on the fact that in young animals addition is a much more active process than in adults.

Aging↗