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Biomedical subjects

D Woodhouse

Publications and source records attributed to D Woodhouse.

13 recordsLinked to original sources
PubMed1993

Dopa resistance in multiple-system atrophy: loss of postsynaptic D2 receptors.

Postmortem autoradiography was used to explore the mechanisms underlying L-dopa resistance in 2 patients with multiple-system atrophy. Indices of striatal presynaptic dopamine terminal loss and dopamine (D1 and D2) receptors were provided by 3H-mazindol, 3H-SCH 23390, and 125I-sulpiride binding. Neuronal loss, gliosis, and loss of postsynaptic D2 receptors preferentially involved the middle and posterior of the putamen, that region of the striatum most intimately involved in motor function. Loss of D1 receptors in the same area occurred in only 1 patient. These findings suggest that in multiple-system atrophy, resistance to L-dopa is due to a loss of putamental D2 receptors. The differential effects on D1 and D2 receptors in 1 patient implies that different subpopulations of striatal neurons were selectively involved.

Aged↗
PubMed1992

Depo-Medrol.

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Anti-Inflammatory Agents↗
PubMed1988

Shoulder dystocia.

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Delivery, Obstetric↗
PubMed1975

Immunoreactive calcitonin production by human lung carcinoma cells in culture.

Monolayer cultures have been established from a poorly differentiated carcinoma of the lung. Homogeneous cell growth and morphology have been maintained for over 18 months through more than 80 subculture passages, and the cells have been found to produce both immunoreactive calcitonin and an immunoreactive carcinoembryonic antigen-like material.

Aged↗
PubMedDate not supplied

The use of unlicensed assistive personnel and selected outcome indications.

This pilot study examine the satisfaction levels of patients, RNs, and UAPs after implementing a patient care delivery system using UAPs as nurse extenders on a 41-bed short-stay medical-surgical observation unit. It also compared patient fall statistics prior to and after implementing the new care model. The convenience study sample included 40 patients, 15 RNs, and 9 UAPs and covered 2 months of unit experience in mid 1997. Risk management statistics from a comparable period 2 years prior showed no significant difference in the number of patient falls. Patient satisfaction scores on five of the seven regularly collected questions was higher in 1997 than the comparable earlier period. RN satisfaction with the care model using UAPs was above a neutral score of 3 on a 5-point Likert scale on two out of three items, but additional attention to the RN's role in effective delegation to UAPs was needed.

Accidental Falls↗