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Biomedical subjects

D Woods

Publications and source records attributed to D Woods.

At least 19 recordsLinked to original sources
PubMed1992

Mutations in the conserved domain of SRY are uncommon in XY gonadal dysgenesis.

In order to evaluate the role of SRY in the determination of the testis, we sequenced the conserved domain of the SRY gene in 8 patients with 46,XY gonadal dysgenesis and 3 patients with related disorders, and compared our data with those obtained in 6 other similar studies. In our study, a 609-bp fragment of SRY was amplified by the polymerase chain reaction and the internal conserved motif was sequenced. SRY sequences did not differ from those in normal males in any of our patients. Overall, 5 de novo mutations have been identified among 56 patients with sporadic XY gonadal dysgenesis (8.9%), and 2 de novo mutations have been identified among 18 patients with related conditions (11%). The unexpectedly low frequency of mutations within the SRY conserved domain in these patients could be caused by undetected Y-linked mutations outside the conserved domain in regions that control transcription during development (e.g., promoter/enhancer regions) or to downstream mutations in other sex-determining genes that need not map to the Y.

Adolescent↗
PubMed1992

Incorrect positioning of nasogastric feeding tubes and the development of pneumothorax.

The authors describe 12 patients in whom feeding tubes were inadvertently placed in the bronchial tree a total of 14 times. All but four of the misplacements were complicated by pneumothorax. No deaths were directly attributable to the misplacements, although one cardiac arrest occurred as a late complication of intrapleural feeding. Careful, controlled insertion of feeding tubes and radiographic confirmation of their placement are essential to reduce morbidity and mortality.

Aged↗
PubMed1991

Glycolipid receptor binding specificity of exoenzyme S from Pseudomonas aeruginosa.

By use of the tlc overlay procedure we have shown that exoenzyme S extracted from cultures of Pseudomonas aeruginosa specifically binds to the glycolipids asialoGM1, asialoGM2 and to a lesser extent lactosyl ceramide. More significantly, strong binding was also observed to the glycerolipid receptor we have detected for Helicobacter pylori (Lancet ii, 238-241.1989). Exoenzyme S can be extracted in a toxic and nontoxic form. Toxicity correlated with ability to bind the H. pylori receptor. This species was the only receptor detected in the most sensitive cell lines. The relative binding of exoenzyme S to the ganglio series glycolipids and the glycerolipid receptor was modified in a reciprocal manner in the presence of metal ions, suggesting that exoenzyme S has two interrelated receptor binding sites.

ADP Ribose Transferases↗
PubMed1991

Validation of the Pethna toy through changes in collateral behaviours.

The Pethna toy is a recently developed toy designed for people with severe and profound mental handicaps. It delivers sensory consequences for the use of simple manipulanda. Two experimental studies evaluated the Pethna toy by monitoring changes in multiple, collateral behaviours. Experiment I demonstrated statistically significant decreases in turn away and stereotyped behaviour and increases in smiling. Experiment II demonstrated highly idiosyncratic changes in collateral behaviours in three adults with multiple handicaps. In all cases, turn away decreased. The role of response-response relationship, subject attention and relationship of sensory behaviours to stereotypies are discussed.

Adult↗
PubMed1991

Isolated colonic hemangioma in a child.

Hemangiomas of the large bowel are very rare and usually occur in the rectosigmoid. A large cavernous hemangioma of the colon was demonstrated in a 9-month-old child who presented with recurrent lower gastrointestinal tract bleeding. Barium examination demonstrated an annular lesion of the hepatic flexure. Computed tomography demonstrated the extent of the lesion, and contrast enhancement suggested the vascular nature of the tumour before a laparotomy was performed to remove the tumour.

Colonic Neoplasms↗
PubMed1991

Presacral extramedullary hematopoiesis in thalassemia intermedia.

Extramedullary hematopoiesis is manifested by several clinical hematologic disorders including beta-thalassemia major and thalassemia intermedia. We report an unusual case of extramedullary hematopoiesis, which presented as a painful presacral mass in a patient with beta-thalassemia intermedia. The diagnosis was confirmed by a needle biopsy guided by computed tomography. The patient responded well to radiation therapy to the sacral region.

Adult↗
PubMed1991

Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.

Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-dependent decrease in the short-circuit current (SCC) and potential difference (PD). This response was reversible after the anesthetic gas was discontinued. Pretreatment with either alpha-adrenergic or beta-adrenergic antagonists (phentolamine or timolol) had no effect on the halothane-induced decrease in SCC. Delivery of the analgestic gas N2O did not alter baseline electrical measurements across the isolated I-CB.

Analysis of Variance↗
PubMed1991

The Koch pouch: radiographic evaluation of the orthotopic and cutaneous forms.

The Koch pouch is a continent ileal reservoir. It has several advantages over the standard ileal conduit. The pouch can be attached to the skin (cutaneous type) or the male urethra (orthotopic type). Both variations have special imaging considerations. The suggested imaging protocol is based upon experience with 47 patients (22 with orthotopic and 25 with cutaneous pouches). The normal appearance of the new and mature pouch and its complications and their management are presented.

Adolescent↗
PubMed1989

The professional practice climate and peer review.

Peer review, a mechanism of professional self-regulation, should not be viewed in isolation. It is one element of a professional practice climate and is interrelated to primary nursing, evaluation of patient outcomes, quality assurance, and self-governance. Much has been written about peer review but little of it describes how staff nurses and administrators can collaborate to operationalize the concept. The peer review system described represents the efforts of one unit's nursing staff at University Hospitals of Cleveland.

Humans↗
PubMed1989

Late-onset cystic hygromas: the role of CT.

Cystic hygromas usually present in the first two years of life. We report a retrospective study of nine patients who first presented with neck and mediastinal masses after two years of age. The clinical evaluation of size, margins, and presence of respiratory symptoms can be used to select those requiring preoperative computed tomography. The five patients who had this examination all demonstrated mediastinal or axillary involvement. Patients in this older subset appear to be different from those presenting as infants because of the incidence of extension and the frequency with which disease is found outside of the posterior triangle.

Adolescent↗
PubMed1989

Inflammatory abdominal aortic aneurysm: a cause of urinary obstruction and acute renal failure.

Abdominal aortic aneurysms are rare causes of ureteric obstruction. We report three cases of inflammatory abdominal aortic aneurysm producing hydronephrosis. In two patients acute renal failure preceded this presentation. The diagnosis can be established by computed tomography when mural thrombus, wall calcification, and an enhancing periaortic soft-tissue mantle are present. It is important to recognize this disease preoperatively.

Acute Kidney Injury↗