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Biomedical subjects

D Worgan

Publications and source records attributed to D Worgan.

9 recordsLinked to original sources

Autosomal dominantly inherited adductor laryngeal paralysis--a new syndrome with a suggestion of linkage to HLA.

A family is reported with autosomal dominantly inherited congenital bilateral adductor paralysis of the larynx. This disorder has apparently not been described previously. A search for linkage in this family with the loci for 19 other genetic markers showed a suggestion of linkage with HLA and GLO, and accordingly a suggestion that the locus for this disorder may be assigned to chromosome 6.

Adolescent↗

The penetration of minocycline into human sinus secretions.

The mean minocycline content of sinus secretions aspirated during antral wash-out in 8 patients sinusitis was found to be 1.06 mug. per ml. (SD.1.03). This exceeds the M.I.C. for most strains of bacteria likely to be found in sinusitis. The mean minocycline serum level in these 8 patients was 3.16 mug. per ml. (S.D. 1.64). The sinus secretion to serum level ratio was therefore 0.34:1. No correlation was found between serum level and sinus secretion level, nor could any of the factors looked at in this study be correlated with the degree to which minocycline penetrated the sinus secretion.

Adolescent↗