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Biomedical subjects

D Wyler

Publications and source records attributed to D Wyler.

30 records · Page 2Linked to original sources
PubMed1992

Human cutaneous leishmaniasis: in-vitro parasite--mononuclear cell interactions in immune and naive individuals.

The aim of this study was to compare the ability of Leishmania parasites to survive in mononuclear cells from immune individuals with their ability to survive in cells from naive individuals. For this purpose we established an in vitro system based on the co-culture in suspension of human peripheral blood leukocytes derived from immune and naive subjects and L. major promastigotes. The proportion of monocytes containing intracellular parasites and the number of amastigotes per 100 infected monocytes (parasite burden) were determined 24 and 72 h after in-vitro infection. The proportion of infected cells from naive individuals did not change, and the number of amastigotes either did not change or increased by 1.2 to 1.7-fold between 24 and 72 h incubation. In contrast, in the immune subjects, the proportion of infected monocytes 24 h after infection was lower than in the naive individuals, and a 30-90% decrease in both the proportion of infected monocytes and the parasite burden was observed after 72 h incubation. Based on these results, three characteristics of leishmanicidal activity of mononuclear cells from immune individuals were determined: (a) the proportion of infected monocytes 24 h after infection was lower than 22%; (b) there was a decrease of more than 30% in the proportion of infected monocytes between 24 and 72 h after infection; and (c) there was a significant decrease in the number of amastigotes between 24 and 72 h after infection. The results of this study demonstrate an enhanced leishmanicidal activity of mononuclear cells from immune individuals.

Humans↗
PubMed1989

[A case of Erdheim-Gsell medial necrosis in combination with mucoid degeneration of a single muscular artery].

We report about a 81-year-old woman who collapsed and died a short time after announcing thoracal pain. The autopsy revealed an acute ruptured thoracic aortal dissection as a consequence of medionecrosis Erdheim-Gsell as well as mucoid media degeneration of several arteries of the muscular type. As far as we know this is a very uncommon combination of two separate non-arteriosclerotic media lesions.

Aged↗
PubMed1979

Cutaneous leishmaniasis--a case with persistent organisms after treatment in presence of normal immune response.

A Peace Corps volunteer in Senegal, West Africa contracted cutaneous leishmaniasis which had several noteworthy features. One of the three presenting cutaneous ulcers was associated with subcutaneous nodules and viable organisms were recovered from healing lesions after multiple courses of treatment, including amphotericin B. Yet, the patient was found to exhibit both humoral and cell mediated features of normal immunologic responsiveness. Ultimately, clinical and parasitological cure occurred. The patient's organism was found to produce lesions in the foot pads of mice.

Adult↗
PubMedDate not supplied

[The "golden sniff": suicide by sniffing heroin].

The best known but apparently rare method to commit suicide by the intake of drugs is the 'golden shot'. As a result of a criminalistic scrutiny in combination with an exploration of the medical history, the findings of the autopsy and the toxicological analysis it is often not possible to discriminate between an accidental and a suicidal intoxication. The manner of death is therefore in most cases undeterminable. The presented unusual suicide by a letal opiate intoxication do to sniffing the drug would not have been clarified, neither with a complete examination of the history, an entirely performed autopsy, the determination of the way of ingestion of the drug nor with a complete toxicological analysis. The diagnosis is based primarily on the availability of a farewell letter. This case demonstrates that it is very difficult to determine the manner of death. Examining drug addicts it is exceedingly important to perform an overall examination by visiting the scene, by inspecting there the corps and the environment and by performing a complete autopsy with toxilogical examinations.

Administration, Inhalation↗