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Biomedical subjects

D Y Cho

Publications and source records attributed to D Y Cho.

At least 55 records · Page 3Linked to original sources

Intracranial lipoma in the medulla oblongata.

Intracranial lipoma in the medulla oblongata has been rarely reported. Only two cases have been documented in the literature. This report concerns a patient who complained of nuchal soreness and an unstable gait for 6 months. An olivelike lipoma, arising from the posterior aspect of the medulla oblongata and embedded in the lower cranial nerves, was found at suboccipital craniectomy and posterior laminectomy of C1-2. Partial removal of the lipoma was performed for decompression; radical removal would have been hazardous. The clinical symptoms subsided postoperatively. The computed tomography scan and magnetic resonance image proved useful for properative diagnosis.

Aged↗

[Intracranial meningiomas--5 year analysis].

Intracranial meningiomas account for 18.2% of all intracranial tumors. During Jan. 1982-Dec. 1986, 65 cases of intracranial meningiomas were diagnosed after operations and pathologic examinations at Taichung Veterans General Hospital. There were 36 females and 29 males, aged from 18 to 80 with a mean of 52 years. Average period of follow-up was 23.7 months. All patients received craniotomy or craniectomy with or without microscopic technique to remove the tumors & 3 cases received postoperative radiotherapy. The most common sites of meningiomas were the posterior fossa, convexity, parasagittal area and falx. The complete removal rate was 84.8%, the mortality rate 9.1% and the morbidity rate 33%. The major complications were intracerebral hemorrhage, infection of central nerve system, and hydrocephalus. There were 3 cases (4.6%) of multiple meningiomas. The most common symptoms and signs in order were headache, hemiparesis, seizure, nausea and vomiting, conscious disturbance & trigeminal neuralgia. The average duration of symptoms was 18.5 months. There were 9 cases of trigeminal neuralgia and 2 cases of hemifacial spasm. There were 3 cases (5.6%) of recurrence and 4 cases (6.1%) of malignancy. The most frequently found subtypes of meningiomas were the meningotheliomatous type and the transitional type. Mean size of the tumors was 5 cm. Tumor location and its biological behavior were closely related to the removal rate, prognosis and recurrence, while tumor size was of less importance. Ability of daily life was improved and seizure was better controlled by antiepileptic drugs in postoperative days.

Adolescent↗

Micronema deletrix-induced granulomatous osteoarthritis in a lame horse.

Necropsy of a chronically lame 16-year-old thoroughbred gelding revealed granulomatous osteomyelitis and polyarthritis due to a widely disseminated infection by Micronema deletrix. Diagnosis was based upon the nematode's morphology with its characteristic rhabditiform oesophagus. Granulomata, often containing one or more centrally located M. deletrix, were observed histologically in sections prepared from femur, kidney, stomach, lung, adrenal gland and sublumbar lymph nodes. Neither verminous meningo-encephalitis nor cephalic granulomata, which are the more commonly described lesions, was found.

Animals↗

Neuronal ceroidosis (ceroid-lipofuscinosis) in a Blue Heeler dog.

Neuronal ceroidosis was observed in an 18-month-old male Blue Heeler dog which was euthanized after showing a progressive gait and behavior abnormality, depression, paresthesia, and vision deterioration. The brain was slightly atrophic. Histopathology revealed autofluorescent, periodic acid-Schiff, luxol fast blue, and oil red O-positive intracytoplasmic granules in the neurons of the brain and spinal cord. There was a moderate diffuse reduction in the number of cerebellar and cerebrocortical neurons. Ultrastructurally, these neuronal cytosomes were diverse with preponderance of membranous profiles and granular matrix.

Animals↗

Intracranial squamous cell carcinoma in a cow.

An exophthalmic right eye was surgically removed from a nine year old Holstein cow. Subsequent post mortem examination revealed a large intracranial mass at the base of the brain which was diagnosed as a squamous cell carcinoma. The orbital and sphenoid bones were intact and it is believed that the neoplasm entered the cranial cavity from the orbit via the foramen orbitorotundum. Both intracranial squamous cell carcinoma and extension of orbital neoplasia through foramina are rare.

Animals↗

Blind-end atresia coli in two foals.

Blind-end atresia coli was observed in two genetically unrelated foals at about the same time and location. The two foals, one an Appaloosa and the other a Quarterhorse, were born 4 days apart on nearby but separate farms. The Appaloosa foal died after surgical anastomosis of the affected segments of the colon. The Quarterhorse foal was euthanized after the defect was found at laparotomy. Both foals were necropsied and representative tissues were examined histopathologically. Histopathologic results were unremarkable. No cause of the defects could be determined and the timing and geographical location of the two events were considered coincidental.

Animals↗

Juvenile-onset hypothyroidism in a dog.

Juvenile-onset hypothyroidism was diagnosed in an adult mixed-breed dog examined because of quadraparesis. Unusual clinical signs attributable to juvenile-onset or congenital hypothyroidism included disproportionate dwarfism; enlarged, protruding tongue; mental dullness; and retention of a "puppy" coat, which was soft and fluffy, without guard hairs. Radiography of the vertebral column and long bones revealed multiple areas of delayed epiphyseal closure and epiphyseal dysgenesis. Myelography demonstrated several intervertebral disk protrusions in the cervical and lumbar regions. Hypothyroidism was confirmed on the basis of a low basal serum thyroxine concentration that failed to increase after the administration of thyroid stimulating hormone. Other laboratory abnormalities included nonregenerative, normocytic, normochromic anemia; mild hypercalcemia; and an impaired growth hormone (GH) secretory response after xylazine administration. At necropsy, the thyroid gland was small and weighed only 0.2g. Microscopic examination of the thyroid gland revealed a loss of glandular tissue, which was replaced by adipose tissue along its periphery. Gross or microscopic abnormalities were not noted in the pituitary gland, and immunohistochemical staining of the pituitary gland revealed a normal number of GH-containing acidophils. This suggests that primary hypothyroidism may result in an impaired secretion of growth hormone, and that pituitary dwarfism or GH deficiency may be difficult to differentiate from hypothyroid dwarfism on the basis of provocative GH testing alone.

Age Factors↗

Micronema granuloma in the gingiva of a horse.

A well-circumscribed proliferative mass was protruding from the body of the mandible of a 4-year-old Appaloosa gelding. The mass was uniformly firm and was ulcerated on the dorsal surface. The horse was euthanatized due to extensive involvement of the jaw and difficulty in eating. Microscopically, the mass consisted of numerous discrete microgranulomas separated by bands of abundant fibrous connective tissue containing lymphocytes, plasma cells, and histiocytic macrophages. Numerous rhabditiform nematodes were in the microgranulomas as well as in the surrounding connective tissue. The nematodes were identified as Micronema species.

Animals↗

Holoprosencephaly in a bovine calf.

Holoprosencephaly, a rare brain malformation previously unreported in the bovine species, was observed in a female Hereford calf. The malformation was characterized by lack of the longitudinal cerebral fissure and the falx cerebri with fusion of the cerebral hemispheres and a single hydrocephalically dilated lateral ventricle, absence of olfactory bulbs and nerves, corpus callosum and septum pellucidum, and heterotopia. The face was flat. There were mild ocular hypotelorism and severe microphthalmia. The morphological features of this bovine case were compared to those of human infants, and various possible etiologic factors and pathogenesis were discussed.

Abnormalities, Multiple↗

Congestive cardiomyopathy in a dog associated with pregnancy.

A two-year-old, six-week postpartum female dog was presented with acute congestive heart failure for treatment. The patient collapsed and suddenly died. Postmortem examination revealed an enlarged, dilated heart with thin ventricular walls. Histologically, scattered multifocal areas of myocardial degeneration and necrosis with fibrosis were seen in the myocardium. This case of acute cardiomyopathy in a female dog six weeks postpartum is similar to the well-described, postpartum cardiomyopathy in man. The etiology of this case was not ascertained.

Animals↗

Isolation of feline herpesvirus 1 from a young kitten.

Five kittens exposed neonatally to older cats exhibiting fever with nasal and ocular discharge became ill and died within 10 days of the onset of illness. One kitten which died at 16 days old was examined post mortem and feline herpesvirus 1 was isolated from the brain, liver, lung and spleen.

Animals↗

Trochanteric intra-osseous venography in femoral neck fractures in the dog.

This study of the healing of femoral neck fractures in dogs clearly indicates: 1. that the restoration of the intra-osseous flow through the fracture site occurs first followed by the appearance of venous drainage in the medial femoral circumflex vein and the vein of the ligamentum teres. 2. That if the intra-osseous flow is restored to the head through the fracture callus, normal fracture healing will proceed. 3. That avascular necrosis following a femoral neck fracture is also dependant on fracture union, and 4. that the incidence of traumatic avascular necrosis can be minimised by adquate fracture treatment. Thus accurate reduction and rigid immobilisation of the fracture promotes early formation of good endosteal callus and the restoration of intra-osseous venous blood flow and so early fracture union. The diagnosis of avascular necrosis of the femoral head may be established by measuring the clearance time of contrast medium flowing into the head via the crossing veins. If the contrast medium is cleared rapidly by the draining veins, it suggests that the head is viable.

Animals↗

Hereditary neuraxial edema in Polled Hereford calves.

Two newborn Polled Hereford calves with hereditary neuraxial edema were available for clinical and pathological examination. The affected animals showed extensor spasms and were unable to rise. Pathologic lesions were microscopic and consisted of widespread vacuolation of the neuraxis, chiefly in white matter and less markedly in grey matter. The lesions were most severe in the brain stem and cerebellar white matter. Examination of the breeding record indicated sire-daughters matings and thus a probably autosomal recessive mode of inheritance.

Animals↗

Anencephaly in calves.

Anencephaly occurred in four calves and was characterized by cranioschisis, absence of the diencephalon with the cerebral hemispheres and rostral midbrain, various forms of eye defects, and relatively normal development of caudal brain stem, cerebellum and spinal cord. Amorphous dysplastic vestiges of the cerebral tissue protruded into the cranial defects. Morphologic features varied but were essentially similar. The cerebellum was absent in one case. Anencephaly in calves at least those we observed and defined in this study is localized defect confined to the brain, eye and skull. No spinal defect was observed in the calves.

Anencephaly↗