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D Z Doganoc

Publications and source records attributed to D Z Doganoc.

7 recordsLinked to original sources
PubMed2003

Trace elements in Slovenian poultry tissues.

In this paper, the contamination of poultry tissues by trace elements in Slovenia is examined from a public health standpoint. During systematic veterinary and sanitary monitoring of foodstuffs of animal origin from 1997 to 1999, 21 poultry meat samples, 70 poultry liver tissue samples, and 184 poultry kidney tissue samples were examined for Pb, Cd, and Hg contents. The levels of poultry tissue contamination in six regions of Slovenia were determined. All samples met Slovenian standards except one poultry kidney tissue sample, which exceeded the Hg level allowed. The difference between chicken and turkey contamination levels was statistically significant (P < 0.05) only for Cd content in kidney tissues. Poultry kidney tissue Cd contents differed for different geographical regions (P < 0.05).

Animals↗
PubMed2002

Ivermectin pharmacokinetics in lactating sheep.

Ivermectin (IVM) concentrations in plasma and milk were studied in six Istrian Pramenka dairy sheep after a single subcutaneous dose of 0.2 mg/kg b.w. of IVM in the early lactation period to describe IVM disposition in milk and to evaluate the transfer of IVM residues via milk to suckling lambs. Large inter-animal in concentration variability of IVM in both matrices was observed. The highest overall concentration was found in the same animal: 21.7 microg/l of H(2)B(1a) in plasma on the second day and 44.9 microg/kg of H(2)B(1a) in milk on the first day after the drug was administered. The mean time in which IVM concentrations fell below the limit of detection for the whole ewe group was 22 and 23 days for plasma and milk, respectively. Time course of IVM concentration in milk was following the time course of IVM concentration in plasma, with an overall mean+/-S.D. of milk/plasma ratio of 1.67+/-0.50 for the first 7 days of the experiment. A mean of 0.7% of the dose was excreted through milk. Individual pharmacokinetic parameters were determined by fitting a one-compartment model to the milk and plasma concentration-time profiles. Mean t(max), c(max), t(1/2k(e)) and AUC values for plasma data were: 1.70+/-0.65 days, 11.88+/-6.96 microg/l, 2.85+/-1.97 days and 63.99+/-28.34 microg day/l, respectively, and for milk: 1.28+/-1.07 days, 22.67+/-18.27 microg/l, 3.56+/-2.01 days and 114.60+/-60.41 microg day/l, respectively. The highest level of concentration in suckling lamb plasma, 0.36 microg/l of H(2)B(1a), was slightly above the limit of determination. The mean lamb to ewe ratio of areas under the plasma concentration-time curve for the first 5 days was 0.02. On the basis of obtained results, it can therefore be claimed that indirect IVM exposure of the suckling lambs via milk was negligible.

Animals↗
PubMedDate not supplied

Lead and cadmium concentrations in meat, liver and kidney of Slovenian cattle and pigs from 1989 to 1993.

This paper describes the results of investigation into the concentrations of lead and cadmium in tissues of pigs and cattle from slaughterhouses in Slovenia in the period between 1989 and 1993. Analyses were performed by flame atomic absorption spectrometry. Quality assurance was carried out by analysis of certified reference materials and recovery tests. The mean concentrations of lead in bovine meat, liver and kidney were 0.05, 0.10 and 0.14 mg/kg wet weight and those in the corresponding pig tissues were < 0.05, 0.06 and 0.06 mg/kg wet weight. The mean cadmium concentrations in bovine meat, liver and kidney were 0.004, 0.094 and 0.373 mg/kg wet weight, respectively, while those in the corresponding pig tissues were 0.010, 0.088 and 0.393 mg/kg wet weight. The majority of tissues analysed corresponded to our valid tolerances for both elements, which had not been the case in the previous 5 year period. The agreement with tolerances was to be expected because in 1990 the Veterinary Directorate of Slovenia prescribed a directive on the basis of which kidneys of cattle older than 5 years and pigs older then 2 years should be regarded as unfit for human consumption.

Animals↗