Biomedical subjects

Daisuke Koide

Publications and source records attributed to Daisuke Koide.

3 recordsLinked to original sources

PubMed2006

Evaluation of electronic health records from viewpoint of patients.

OBJECTIVE: To clarify the impacts of electronic health records (EHRs) on patients, especially patient's satisfaction by using questionnaire. DESIGN: Surveys were conducted at three hospitals. One of them was surveyed three times; three-months before (pre-EHR) and three-months after (post-3mo EHR) and nine-months after implementation of EHR (post-9mo EHR). The other two hospitals (metropolitan-stable EHR and suburban-stable EHR) spent more than three years after implementation. Thus there were five stages of EHR. MEASUREMENTS: Comparisons were made among these five stages. RESULTS: The longer EHR has been operating, the more patients answered waiting time shortened. The patients in pre-EHR (73%) expected the benefit of cooperation between hospitals and clinics using EHR more. The longer experience of EHR a hospital had, the more patients were explained by watching the screen. Although overall satisfaction was high, there was no difference among the stages except metropolitan-stable EHR. CONCLUSION: Main benefits of EHR are reducing patient's waiting time, and enhancing explanation to patients. However it does not have significant effects to improve patient's satisfaction.

Adolescent↗

PubMed2004

Comparison of data mining methodologies using Japanese spontaneous reports.

PURPOSE: Five data mining methodologies for detecting a possible signal from spontaneous reports on adverse drug reactions (ADRs) were compared. METHODS: The five methodologies, the Bayesian method using the Gamma Poissson Shrinker (GPS), the method employed in the UK Medicines Control Agency (MCA), the Bayesian Confidence Propagation Neural Network (BCPNN), the method using the 95% confidence interval (CI) for the reporting odds ratio (RORCI) and that using the 95% CI of the proportional reporting ratio (PRRCI) were compared using Japanese data obtained between 1998 and 2000. RESULTS: There were all in all 38,731 drug-ADR combinations. The count of drug-ADR pairs was equal to 1 or 2 for 31,230 combinations and none of them were identified as a possible signal with the MCA or BCPNN. Similarly, the GPS detected a possible signal in none of the combinations where the count was equal to 1 but in 7.5% of the combinations where the count was equal to 2. The RORCI and PRRCI detected a possible signal in more than half of the combinations where the count was equal to 1 or 2. When the pairwise agreement on whether or not a drug-ADR combination satisfied the criteria for a possible signal was assessed for the 38,731 combinations, the concordance measure kappa was greater than 0.9 between the MCA and BCPNN and between the RORCI and PRRCI. Kappa was around 0.6 between the GPS and MCA and between the GPS and BCPNN. Otherwise, kappa was smaller than 0.2. CONCLUSIONS: The drug-ADR combinations detected as a possible signal vary between different methodologies.

Adverse Drug Reaction Reporting Systems↗

PubMed2002

Calcium channel blockers and myocardial infarction: a case--control study in a Japanese hospital.

PURPOSE: To examine the relationship of the use of calcium channel blockers (CCBs) in hypertensive patients to myocardial infarction in Japan, where CCBs are prescribed much more frequently than in Europe and America. DESIGN: We conducted a nested case-control study using a hospital information system in Japan. SUBJECTS: Cases were hypertensive patients who were repeat visitors to Tokyo University Hospital as of April 1996 and had an incidence of fatal or non-fatal myocardial infarction between 1996 and 1999. Controls were hypertensive patients individually matched to cases by sex, age and history of angina pectoris. RESULTS: The study consisted of 16 cases, who were matched to 80 controls. Of the 80 control patients, 54 (68%) received CCBs. On the other hand, all but one of 16 cases received CCBs and the crude odds ratio of myocardial infarction associated with the use of calcium channel blockers was as high as 7.0 (0.9-55.3). The odds ratio was reduced to 4.9 (0.6-42.4) when adjusted by diabetes and diastolic blood pressure. CONCLUSIONS: Although the crude odds ratio of myocardial infarction associated with CCBs was high, the ratio was reduced when adjusted by known confounding factors, suggesting a mechanism of confounding by indication. In addition, the results obtained in this study using records from a single hospital should not be generalized.

Aged↗