BACKGROUND AND OBJECTIVES: Genital warts represent benign epithelial proliferations induced by human papillomavirus. The goal of treatment is the clearance of visible warts. Different regimens are available. Flashlamp-pumped pulsed dye laser (FPDL) represents one of many treatment options for the management of viral warts (verrucae vulgares), its effectiveness being comparable with that of conventional therapies. We evaluated the effectivity of FPDL light for the treatment of genital warts. STUDY DESIGN/MATERIALS AND METHODS: A prospective study was performed to examine the efficacy of FPDL in untreated genital warts in which 22 patients were included. RESULTS: All patients showed complete remission after 1.59 (1-5) laser sessions and no scarring was observed. CONCLUSIONS: This study demonstrate that FPDL is a simple and safe, cost and time saving alternative treatment option for genital warts and should be listed in genital warts treatment guidelines.

Adolescent↗

PubMed2006

Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case.

Phosphatidylcholine, a lecithin extracted from soy beans, is able to lower serum cholesterol to some extent. When applied intralesionally within fat tissues, it is supposed to act as a "fat burner" and reduce undesired fat deposits. We applied intralesionally phosphatidylcholine within a lipoma of a young patient. To evaluate the volume of the lipoma sonographic imaging was performed before treatment and one month after the third application. Only a partial reduction of the lipoma could be achieved, and increased echographic density could be observed after the third intralesional application of phosphatidylcholine. Surgical excision was performed. Histologic examination showed focal fibrosis, inflammatory reaction with granulomatous features, and presence of pseudomembranous degeneration of fat tissue. Off-label intralesional use of phosphatidylcholine as "fat burner" for the reduction of aesthetically disturbing lipomas should be considered only on a case-to-case basis after careful consideration of possible undesired effects similar to those described in our patient.

Adult↗

PubMed2005

[KTP laser coagulation for xanthelasma palpebrarum].

BACKGROUND: Xanthelasma palpebrarum is a benign skin disorder of unknown etiology appearing as one or multiple yellowish plaques around the eyelids. Hyperlipidemia, thyroid dysfunction, and diabetes mellitus are possible pathogenetic triggers. Removal of xanthelasma is desired for aesthetic reasons. While there are many treatment options, search continue for newer methods with less scarring and post-inflammatory hyperpigmentation. PATIENTS AND METHODS: We employed for the first time KTP laser (532 nm) for the treatment of 14 patients with xanthelasma palpebrarum on 33 eyelids. RESULTS: More than 70% of the patients tolerated KTP laser irradiation without any analgesia. 85.7% showed respectable reduction of xanthelasma palpebrarum after one to three treatment sessions without side effects. CONCLUSIONS: KTP laser irradiation represents a minimally invasive, safe and effective treatment option for the reduction of xanthelasma palpebrarum without undesired side effects.

Adult↗

PubMed2004

Locoregional cutaneous metastases of malignant melanoma and their management.

The correct classification of locoregional metastases of malignant melanoma to skin is central to the planning of treatment. Local recurrence means persistence of neoplastic cells at the local site by virtue of incomplete excision of the primary melanoma. Standard treatment is excisional surgery. In contrast, locoregional metastases of malignant melanoma (satellites, in-transit metastases) are metastases around a primary melanoma or between a primary melanoma and regional lymph nodes. They represent intralymphatic or hematogenous spread of neoplastic cells. We present a variety of available treatment options and discuss especially topical imiquimod as a novel approach for the palliative treatment of locoregional cutaneous melanoma metastases in selected patients.

Aged↗

PubMed2003

Verrucae vulgares: flashlamp-pumped pulsed dye laser treatment in 134 patients.

BACKGROUND: Various approaches have been taken in the management of verrucae vulgares, but there is still no first-choice treatment. Thus, a study was designed to evaluate the efficacy of a flashlamp-pumped pulsed dye laser (FPDL) in the treatment of verrucae vulgares. METHODS: Within 18 months, 134 patients with recalcitrant or untreated verrucae vulgares on their hands or feet, or in other sites, were exposed to a 585-nm FPDL every 3.26 weeks. The following parameters were used: energy density, 8 J/cm2; spot size, 7 mm; pulse duration, 450 micro s. Concomitant topical treatment was not recommended. RESULTS: Eight patients were lost to follow-up. The data of 126 patients were evaluated. Up to eight laser treatments led to total remission in 62.69% of patients and partial remission in 21.42%; 9.52% did not respond to this type of management; 6.34% of patients classified the method as too painful and withdrew after the first one or two treatments. In a median follow-up period of 5.38 months (2-16 months), one relapse occurred. CONCLUSIONS: FPDL is safe and effective for the removal or reduction of verrucae vulgares, and requires less patient compliance compared with other treatment options.

Adolescent↗

PubMed2003

Hair reduction: 48 months of experience with 800nm diode laser.

BACKGROUND: The goal of hair removal methods has always been permanent or at least long-term epilation. Laser technology and the axiom of selective photothermolysis allowed a new approach to this subject. OBJECTIVE: The aim of this retrospective study was to determine the long-term efficacy of a solid state, 800nm pulsed near infrared diode laser system for the reduction of pigmented hair, and extending habitual hair plucking intervals. METHODS: In 48 months 242 patients received 703 diode laser treatments on 477 sites. Treatment data and an anonymous patient questionnaire on data concerning undesired hair growth (e.g. predisposition, psychological aspects), and hair plucking habits were retrospectively evaluated to verify the benefit of 800-nm diode laser application for the reduction of excess hair. RESULTS: After an average of 1.97 treatments (range 1-6) sufficient reduction of pigmented hair was achieved for a mean period of 8.1 months. The habitual hair plucking interval was raised from a mean of 3.69 days before treatment to 15.19 days after laser epilation. The procedure was tolerated by 81.4% without local anesthetics and well accepted by 82.55% of the patients. CONCLUSION: 800-nm diode laser assisted hair removal represents a safe and effective treatment option for the reduction of pigmented hair.

Adolescent↗

PubMed2003

Failure of prolonged extracorporeal photopheresis in the treatment of alopecia areata universalis in two patients.

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Adult↗